Changes in the amount of D-aspartic acid in the human femur with age

Growth, Development and Aging

Volumn 62, Issue 4, 1998, Pages 141-148

  Ohtani, Susumu ^a   Yamamoto, Toshiharu ^a   Matsushima, Yoshibumi ^b   Kobayashi, Yasuhito ^b  

^a KANAGAWA DENTAL COLLEGE   (Japan)

^b SAITAMA CANCER CENTER   (Japan)

Author keywords

Age; Bone; D aspartic acid; Femur; Racemization

Indexed keywords

AMINO ACID; COLLAGEN; DEXTRO ASPARTIC ACID; HORMONE; PROTEIN;

ADOLESCENT; ADULT; AGED; AGING; ARTICLE; BONE DISEASE; CONTROLLED STUDY; FEMALE; FEMUR; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; SEX DIFFERENCE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; ASPARTIC ACID; CHILD; FEMALE; FEMUR; HUMANS; MALE; MIDDLE AGED;

EID: 0032419512     PISSN: 10411232     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. BADA, J. L. & SCHROEDER, R. A. 1975. Amino acid racemization reactions and their geochemical implications. Naturwissenschaften, 62, 71-9.
2. DIAZ, M. N., O'NEILL, T. W. & SILMAN, A. J. 1997. The influence of family history of hip fracture on the risk of vertebral deformity in men and women: the european vertebral osteoporosis study. Bone, 20, 145-9.
3. FU, S-J. FAN, C-C. SONG, H-W. & WEI, F-Q. 1995. Age estimation using a modified HPLC determination of ratio of aspartic acid in dentin. Forensic, Sci. Int., 73, 35-40.
4. HAUSCHKA, P. V., CARR, S. A. & BIEMANN K. 1982. Primary structure of monkey osteocalcin. Biochem., 21, 638-42.
5. HELFMAN, P. M. & BADA, J. L. 1975. Aspartic acid racemization in tooth enamel from living humans. Proc. Nat. Acad. Sci. USA., 72, 2891-4.
6. HELFMAN, P. M. & BADA, J. L. 1976. Aspartic acid racemisation in dentine as a measure of ageing. Nature, 262, 279-81.
7. LIAN, J. B. & GUNDBERG, C. M. 1988. Osteocalcin, Biochemical considerations and clinical applications. Clin. Orthop. Relat. Res., 226, 267-91.
8. MAN, E. H., SANDHOUSE, M. E., BURG, J. & FISHER, G. H. 1983. Accumulation of D-aspartic acid with age in the human brain. Science, 220, 1407-8.
9. MASTERS, P. M., BADA, J. L. & ZIGLER, J. S. 1978. Aspartic acid racemization in heavy molecular weight crystalline and water-insoluble protein from normal human lenses and cataracts. Proc. Natl. Acad. Sci. USA., 75, 1204-8.
10. MORNSTAD, H. PFEIFFER, H. & TEIVENS, A. 1994. Estimation of dental age using HPLC-technique to determine the degree of aspartic acid racemization. J. Forensic, Sci., 39, 1425-31.
11. OCHI, H., FUHUDA, T., INOUE, Y., MORII, H. & SHIMAZU, A. 1981. Quantitative measurement of bone mineral contents i0n renalosteodystrophy and osteoporosis with XCT and RCT. Bone, Metabolism., 14, 128-34 (in Japanese).
12. OGINO, T. OGINO, H. & NAGY, B. 1985. Application of aspartic acid racemization to forensic odontology: Post mortem designation of age at death. Forensic, Sci. Int., 59, 259-67.
13. OHTANI, S. 1995. Estimation of age from the teeth of unidentified corpses using the amino acid racemization method with reference to actual cases. Am. J. Forensic, Med. Pathol., 16, 238-42.
14. OHTANI, S. OHHIRA, H. WATANABE, A. OGASAWARA, A. & SUGIMOTO, H. 1997. Estimation of age from teeth by amino acid racemization: influence of fixative. J. Forensic, Sci., 42, 137-139.
15. OHTANI, S. & YAMAMOTO, K. 1991. Age estimation using the racemization of amino acid in human dentin. J. Forensic, Sci., 36, 792-800.
16. OHTANI, S. & YAMAMOTO, K. 1992. Estimation of age from a tooth by means of racemization of an amino acid, especially aspartic acid-comparison of enamel and dentin. J. Forensic, Sci., 37, 1061-7.
17. PFEIFFER, H., MORNSTAD, H. & TEIVENS, A. 1995a. Estimation of chronologic age using the aspartic acid racemization method. I. On human rib cartilage. Int. J. Legal Med., 108, 19-23.
18. PFEIFFER, H., MORNSTAD, H. & TEIVENS, A. 1995b. Estimation of chronologic age using the aspartic acid racemization method. II. On human cortical bone. Int. J. Legal Med., 108, 24-6.
19. RIGGS, B. L., MELTON, L. J. III. 1986. Involutional osteoposis. N. Engl. J. Med., 314, 1676-86.
20. RITZ, S. SCHUTZ, H. W. & PEPER, C. 1993. Postmortem estimation of age at death based on aspartic acid racemization in dentin: its applicability for root dentin. Int. J. Legal, Med., 105, 289-93.
21. RITZ, S. SCHUTZ, H. W. & SCHWARZER, B. 1990. The extent of aspartic acid racemization in dentin: a possible method for a more accurate determination of age at death? Z. Rechtsmed., 103, 457-62.
22. RITZ, S., TURZYNSKI, A. & SCHUTZ, H. W. 1994. Estimation of age at death based on aspartic acid racemization in noncollagenous bone proteins. Forensic, Sci. Int., 69, 149-59.
23. RITZ, S., TURZYNSKI, A., SCHUTZ, H. W., HOLLMANN, A, & ROCHHOLZ G. 1996. Identification of osteocalcin as a permanent aging constituent of the bone matrix: basis for an accurate age at death determination. Forensic, Sci. Int., 77, 13-26.
24. SEEMAN, E., HOPPER, J. L., BACH, L. A., COOPER, M. E., PARKINSON, E., MCKAY J. & JERUMS, G. 1989. Reduced bone mass in daughters of women with osteoporosis. N. Engl. J. Med., 320, 554-8.