Developmental effects of boric acid in rats related to maternal blood Boron concentrations

Biological Trace Element Research

Volumn 66, Issue 1-3, 1998, Pages 359-372

  Price, Catherine J ^a   Strong, Philip L ^b   Murray, F Jay ^c   Goldberg, Margaret M ^a  

^a RTI INTERNATIONAL   (United States)

^b Rio Tinto Group   (United States)

^c Murray and Associates   (United States)

Author keywords

Boric acid; Boron; Embryo fetal development; ICP; Kinetics; Pregnancy; Rats

Indexed keywords

BORIC ACID;

ADOLESCENT; BLOOD LEVEL; BONE MALFORMATION; CONFERENCE PAPER; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; FEMALE; FETUS; FETUS GROWTH; FETUS OUTCOME; FETUS WEIGHT; MATERNAL BLOOD; MATERNAL NUTRITION; NONHUMAN; PREGNANCY; RAT; TOXICOKINETICS;

EID: 0032419482     PISSN: 01634984     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02783148     Document Type: Conference Paper

References (47)

1. 1. W. G. Woods, An introduction to boron: history, sources, uses, and chemistry, Environ. Health Perspectives 102(7), 5-11 (1994).
2. 2. D. L. Anderson, W. C. Cunningham, and T. R. Lindstrom, Concentrations and intakes of H, B, S, K, Na, Cl, and NaCl in foods, J. Food Comp. Anal. 7, 59-82 (1994).
3. 3. W. Mertz, Essential trace metals: new definitions based on new paradigms, Nutr. Rev. 51, 287-295 (1993).
4. 4. F. H. Nielsen, Biochemical and physiologic consequences of boron deprivation in humans, Environ. Health Perspectives 102(7), 59-63 (1994).
5. 5. C. Hunt, The biochemical effects of physiological amounts of dietary boron in animal nutrition models, Environ. Health Perspectives 102(7), 35-43 (1994).
6. 3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick, J. Bone Miner. Res. 9(2), 171-182 (1994).
7. 7. C. Hunt and B. J. Stoecker, Deliberations and evaluations of the approaches, endpoints, and paradigms for boron, chromium, and fluoride dietary recommendations, J. Nutr. 126, 2441-2451 (1996).
8. 8. C. D. Hunt, J. L. Herbel, and F. H. Nielsen, Metabolic response of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations, Am. J. Clin. Nutr. 65, 803-813 (1997).
9. 9. World Health Organization (WHO), Trace Elements in Human Nutrition and Health, WHO, Geneva, pp. 175-179 (1996).
10. 10. K. O'Sullivan and M. Taylor, Chronic boric acid poisoning in infants, Arch. Dis. Childhood 58, 737-749 (1983).
11. 11. T. L. Litovitz, W. Klein-Schwartz, G. M. Oderda, and B. F. Schmitz, Clinical manifestations of toxicity in a series of 784 boric acid ingestions, Am. J. Emerg. Med. 6(3), 209-213 (1988).
12. 12. European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Reproductive and general toxicology of some inorganic borates and risks assessment for human beings, Technical Report No. 63 (February 1995).
13. 13. F. J. Murray, A human health risk assessment of boron (boric acid and borax) in drinking water, Regul. Toxicol. Pharmacol. 22, 221-230 (1995).
14. 14. F. J. Murray, C. J. Price, and P. L. Strong, Risk assessment of boric acid (BA): a novel pivotal study, Toxicologist 15 (Abstract 190), 35 (1995).
15. 15. C. L. Smallwood, M. L. Dourson, L. A. Knauf, and C. O. Abernathy, Comparison of some methods for estimating oral doses for boron (B) regulatory purposes, Toxicologist 15 (Abstract 946), 177 (1995).
16. 26. J. A. Moore, An assessment of boric acid and borax using the IEHR evaluative process for assessing human developmental and reproductive toxicity of agents, Reprod. Toxicol. 11(1), 123-160 (1997).
17. 17. C. J. Price, P. L. Strong, M. C. Marr, C. B. Myers, and F. J. Murray, Developmental toxicity NOAEL and postnatal recovery in rats fed boric acid during gestation, Fundam. Appl. Toxicol. 32, 179-193 (1996).
18. 18. B. C. Allen, P. L. Strong, C. J. Price, S. A. Hubbard, and G. P. Daston, Benchmark dose analysis of developmental toxicity in rats exposed to boric acid, Fundam. Appl. Toxicol. 32, 194-204 (1996).
19. 19. R. J. Weir and R. S. Fisher, Toxicologic studies on borax and boric acid, Toxicol. Appl. Pharmacol. 23, 251-364 (1972).
20. 20. National Toxicology Program (NTP), Evaluation of CNS development in Sprague-Dawley (CD®) rats exposed to boric acid (CAS No. 10043-35-3) in feed on gestational days 6 to 15, NTIS No. PB95-149399 (1994).
21. 21. National Toxicology Program (NTP), Evaluation of CNS development in CD rats exposed to boric acid (CAS No. 10043-35-3) in feed on gestational days 14 to 17, NTIS No. PB95-137485 (1994).
22. 22. P. A. Fail, J. D. George, J. C. Seely, T. B. Grizzle, and J. J. Heindel, Reproductive toxicity of boric acid in Swiss (CD-1) mice: assessment using the continuous breeding protocol, Fundam. Appl. Toxicol. 17, 225-239 (1991).
23. 23. K. A. Treinen and R. E. Chapin, Development of testicular lesions in male F344 rats after treatment with boric acid, Toxicol. Appl. Pharmacol. 107, 325-335 (1991).
24. 24. W. W. Ku, R. E. Chapin, R. F. Moseman, R. E. Brink, K. D. Pierce, and K. Y. Adams, Tissue disposition of boron in male Fischer rats, Toxicol. Appl. Pharmacol. 111, 145-151 (1991).
25. 25. W. W. Ku, R. E. Chapin, R. N. Wine, and B. C. Gladen, Testicular toxicity of boric acid (BA): relationship of dose to lesion development and recovery in the F344 rat, Reprod. Toxicol. 7, 305-319 (1993).
26. 26. W. W. Ku, L. M. Shih, and R. E. Chapin, The effects of boric acid (BA) on testicular cells in culture, Reprod. Toxicol. 7, 321-331 (1993).
27. 27. W. W. Ku and R. E. Chapin, Mechanism of the testicular toxicity of boric acid in rats: in vivo and in vitro studies, Environ. Health Perspectives 102(7), 99-105 (1994).
28. 28. J. J. Heindel, C. J. Price, E. A. Field, M. C. Marr, C. B. Myers, R. E. Morrissey, and B. A. Schweiz, Developmental toxicity of boric acid in mice and rats, Fundam. Appl. Toxicol. 18, 266-277 (1992).
29. 29. J. J. Heindel, C. J. Price, and B. A. Schwetz, Developmental toxicity of boric acid in mice, rats, and rabbits, Environ. Health Perspectives 102(7), 107-112 (1994).
30. 30. M. G. Narotsky, B. T. Hamby, D. S. Mitchell, and R. J. Kavlock, Effects of boric acid on axial skeletal development in rats, Teratology 51, 192 (1995).
31. 31. M. G. Narotsky, B. T. Hamby, D. S. Best, and R. J. Kavlock, Effects of single-day boric acid treatment on axial skeletal development in rats, Teratology 53, 101 (1996).
32. 32. C. J. Price, P. L. Strong, M. C. Marr, C. B. Myers, and F. J. Murray, Developmental toxicity NOAEL and postnatal recovery in rats fed boric acid during gestation, J. Am. Coll. Toxicol. 14 (Abstract P17), 173 (1995).
33. 33. C. J. Price, M. C. Marr, C. B. Myers, J. C. Seely, J. J. Heindel, and B. A. Schwetz, The developmental toxicity of boric acid in rabbits, Fundam. Appl. Toxicol. 34, 176-187 (1996).
34. 34. N. L. Kent and R. A. McCance, The absorption and excretion of "minor" elements by man. I. Silver, gold, lithium, boron and vanadium, Biochem. J. 35, 837-844 (1941).
35. 35. J. H. Draize and E. A. Kelley, The urinary excretion of boric acid preparations following oral administration and topical application to intact and damaged skin of rabbits, Toxicol. Appl. Pharmacol. 1, 267-276 (1959).
36. 36. C. Job, Resorption and excretion of orally administered boron, Z. Angew. Bader-Klimahelik. 20, 137-142 (1973).
37. 37. S. Magour, P. Schramel, J. Ovcar, and H. Maser, Uptake and distribution of boron in rats: interaction with ethanol and hexobarbital in the brain, Arch. Environ. Contam. Toxicol. 11, 521-525 (1982).
38. 38. J. S. Schou, J. A. Jansen, and B. Aggerbeck, Human pharmacokinetics and safety of boric acid, Arch. Toxicol. Suppl. 7, 232-235 (1984).
39. 39. H. J. Weeth, C. F. Speth, and D. R. Hanks, Boron content of plasma and urine as indicators of boron intake in cattle, Am. J. Vet. Res. 42(3), 474-477 (1981).
40. 40. J. A. Jansen, J. Andersen, and J. S. Schou, Boric acid single dose pharmacokinetics after intravenous administration to man, Arch. Toxicol. 55, 64-67 (1984).
41. 41. T. F. Brown, M. E. McCormick, D. R. Morris, and L. K. Zeringue, Effects of dietary boron on mineral balance in sheep, Nutr. Res. 9, 503-512 (1989).
42. 42. R. D. Barr, W. B. Clarke, R. M. Clarke, J. Venturelli, G. R. Norman, and R. G. Downing, Regulation of lithium and boron levels in normal human blood: environmental and genetic considerations, J. Lab. Clin. Med. 121(4), 614-619 (1993).
43. 43. R. A. Vanderpool, D. Hof, and P. E. Johnson, Use of inductively coupled plasma-mass spectrometry in boron-10 stable isotope experiments with plants, rats, and humans, Environ. Health Perspectives 102(7), 13-20, (1994).
44. 44. C. J. Price, P. L. Strong, F. J. Murray, and M. M. Goldberg, Blood boron concentrations in pregnant rats fed boric acid throughout gestation, Reprod. Toxicol. 11(6), 833-842 (1997).
45. 45. M. M. Goldberg, Final report: determination of boron in rat blood, RTI Project 5657, RTI technical report submitted to U.S. Borax, Valencia, CA (1996).
46. 46. EXCEL, User's Guide for Microsoft® EXCEL, version 5.0. Chapter 19: Using charts to analyze data, pp. 347-362; Chapter 31: Statistical analysis of data, pp. 589-606. Microsoft Corporation, Cambridge, MA (1993-1994).
47. 47. A. Morien, P. J. Wellman, and J. Fojt, Diurnal rhythms of paraventricular hypothalamic norepinephrine and food intake in rats, Pharmacol. Biochem. Behav. 52(1), 169-174 (1995).