PACAP and GLP-1 protect islet β-cells against Ca2+ toxicity induced by high K+a

Annals of the New York Academy of Sciences

Volumn 865, Issue , 1998, Pages 445-450

  Yaekura, Kazuro ^a   Yanagida, Kazuhiro ^a   Yada, Toshihiko ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; POTASSIUM ION;

ANIMAL CELL; CALCIUM CELL LEVEL; CELL CULTURE; CELL PROTECTION; CONFERENCE PAPER; CONTROLLED STUDY; NONHUMAN; PANCREAS ISLET BETA CELL; RAT;

ANIMALIA;

EID: 0032418190     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb11213.x     Document Type: Conference Paper

References (9)

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3. Gilon, P., R. M. Shepherd & J. C. Henquin. 1993. Oscillations of secretion driven by oscillations of cytoplasmic Ca⊃2+⊃ as evidenced in single pancreatic islets. J. Biol. Chem. 268: 22265-22268.
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6. Yada, T., M. Sakurada, M. Nakata, K. Yaekura & M. Kikuchi. 1996. Current status of PACAP as a regulator of insulin secretion in pancreatic islets. Ann. N.Y. Acad. Sci. 805: 329-342.
7. Yada, T., M. Sakurada, H. Ishihara, M. Nakata, S. Shioda, K. Yaekura, N. Hamakawa, K. Yanagida, M. Kikuchi & Y. Oka. 1997. Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet substance serving as an intra-islet amplifier of glucoseinduced insulin secretion in rats. J. Physiol. (Lond.) 505(2): 319-328.
8. Yada, T., K. Itoh & M. Nakata. 1993. Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3′,5′-monophosphate increase cytosolic free Ca⊃2+⊃ in rat pancreatic β-cells by enhancing Ca⊃2+⊃ channel activity. Endocrinology 133: 1685-1692.
9. Yaekura, K. & T. Yada. 1998. Cytosolic Ca⊃2+⊃-reducing action of cAMP in rat pancreatic β-cells: involvement of thapsigargin-sensitive stores. Am. J. Physiol. 274: C513-C521.