Engraftment of myasthenia gravis thymocytes into severe combined immunodeficiency (SCID) mice

Autoimmunity

Volumn 28, Issue 4, 1998, Pages 217-224

  Yoshikawa, Hiroaki ^a,b  

^a MAYO CLINIC   (United States)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Anti acetylcholine receptor antibody; Myasthenia gravis; SCID mice; T cell; Thymus

Indexed keywords

CD20 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ARTICLE; COMBINED IMMUNODEFICIENCY; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; MOUSE; MYASTHENIA GRAVIS; NONHUMAN; PERITONEAL CAVITY; THYMOCYTE;

EID: 0032417340     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939808995369     Document Type: Article

References (32)

1. Drachman, D.B. Myasthenia gravis. N. Engl. J. Med. 1994; 330: 1797-1810.
2. Bosma, G.C., Custer, R.P. and Bosma, M.J. A severe combined immunodeficiency mutation in the mouse. Nature 1983; 301: 527-530.
3. Bosma, M.J. and Carroll, A.M. The SCID mouse mutant: definition, characterization, and potential uses. Annu. Rev. Immunol. 1991; 9: 323-350.
4. McCune, J.M., Namikawa, R., Kaneshima, H., Shultz, L.D., Lieberman, M. and Weissman, I.L. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 1988; 241: 1632-1639.
5. Mosier, D.E., Gulizia, R.J., Baird, S.M. and Wilson, D.B. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 1988; 335: 256-259.
6. Duchosal, M.A., Eming, S.A., Fischer, P., Leturcq, D., Barbas, C.F.D., McConahey, P.J., Caothien, R.H., Thornton, G.B., Dixon, F.J. and Burton, D.R. Immunization of hu-PBL-SCID mice and the rescue of human monoclonal Fab fragments through combinatorial libraries. Nature 1992; 355: 258-262.
7. Sandhu, J., Shpitz, B., Gallinger, S. and Hozumi, N. Human primary immune response in SCID mice engrafted with human peripheral blood lymphocytes. J. Immunol. 1994; 152: 3806-3813.
8. Ifversen, P., Martensson, C., Danielsson, L., Ingvar, C., Carlsson, R. and Borrebaeck, C.A. Induction of primary antigen-specific immune responses in SCID-hu-PBL by coupled T-B epitopes. Immunology 1995; 84: 111-116.
9. Krams, S.M., Dorshkind, K. and Gershwin, M.E. Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice. J. Exp. Med. 1989; 170: 1919-1930.
10. Duchosal, M.A., McConahey, P.J., Robinson, C.A. and Dixon, F.J. Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice. J. Exp. Med. 1990; 172: 985-988.
11. Ashany, D., Hines, J., Gharavi, A., Mouradian, J. and Elkon, K.B. Analysis of autoantibody production in SCID-systemic lupus erythematosus (SLE) chimeras. Clin. Exp. Immunol. 1992; 88: 84-90.
12. Llorente, L., Zou, W., Levy, Y., Richaud Patin, Y., Wijdenes, J., Alcocer Varela, J., Morel Fourrier, B., Brouet, J.C., Alarcon Segovia, D., Galanaud, P. et al. Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J. Exp. Med. 1995; 181: 839-844.
13. Tighe, H., Silverman, G.J., Kozin, F., Tucker, R., Gulizia, R., Peebles, C., Lotz, M., Rhodes, G., Machold, K., Mosier, D.E. et al. Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients. Eur. J. Immunol. 1990; 20: 1843-1848.
14. Jorgensen, C., Couret, I., Hellier, I., Bologna, C., Canovas, F., Brochier, J., Reme, T. and Sany, J. In vivo migration of radiolabelled lymphocytes in rheumatoid synovial tissue engrafted in SCID mice: implication of beta 2 and beta 7-integrin. J. Rheumatol. 1996; 23: 32-35.
15. Davies, T.F., Kimura, H., Fong, P., Kendler, D., Shultz, L.D., Thung, S. and Martin, A. The SCID-hu mouse and thyroid autoimmunity: characterization of human thyroid autoantibody secretion. Clin. Immunol. Immunopathol. 1991; 60: 319-330.
16. Macht, L., Fukuma, N., Leader, K., Sarsero, D., Pegs, C.A., Phillips, D.I., Yates, P., McLachlan, S.M., Elson, C. and Rees Smith, B. Severe combined immunodeficient (SCID) mice: a model for investigating human thyroid autoantibody synthesis. Clin. Exp. Immunol. 1991; 84: 34-42.
17. Yoshikawa, N., Nishikawa, M., Mori, S., Tokoro, T., Yamamoto, Y., Ikehara, S., Kumazawa, H., Yamashita, T. and Inada, M. Simultaneous xenotransplantation of human Graves' thyroid tissue and autologous bone marrow cells in severe combined immunodeficient mice: successful reconstitution of human Graves' hyperthyroidism. Eur. J. Endocrinol. 1997; 136: 213-222.
18. Schönbeck, S., Padberg, F., Hohlfeld, R. and Wekerle, H. Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice. A new model of myasthenia gravis. J. Clin. Invest. 1992; 90: 245-250.
19. Martino, G., DuPont, B.L., Wollmann, R.L., Bongioanni, P., Anastasi, J., Quintans, J., Arnason, B.G. and Grimaldi, L.M. The human-severe combined immunodeficiency myasthenic mouse model: a new approach for the study of myasthenia gravis. Ann. Neurol. 1993; 34: 48-56.
20. Spuler, S., Sarropoulos, A., Marx, A., Hohlfeld, R. and Wekerle, H. Thymoma-associated myasthenia gravis. Transplantation of thymoma and extrathymomal thymic tissue into SCID mice. Am. J. Pathol. 1996; 148: 1359-1365.
21. Lennon, V.A., Lambert, E.H., Leiby, K.R., Okarma, T.B. and Talib, S. Recombinant human acetylcholine receptor alpha-subunit induces chronic experimental autoimmune myasthenia gravis. J. Immunol. 1991; 146: 2245-2248.
22. Lennon, V.A. and Griesmann, G.E. Evidence against acetylcholine receptor having a main immunogenic region as target for autoantibodies in myasthenia gravis. Neurology 1989; 39: 1069-1076.
23. Markham, R.B. and Donnenberg, A.D. Effect of donor and recipient immunization protocols on primary and secondary human antibody responses in SCID mice reconstituted with human peripheral blood mononuclear cells. Infect. Immun. 1992; 60: 2305-2308.
24. Vandekerckhove, B.A., Krowka, J.F., McCune, J.M., de Vries, J.E., Spits, H. and Roncarolo, M.G. Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse. J. Immunol. 1991; 146: 4173-4179.
25. Sun, J.B., Harcourt, G., Wang, Z.Y., Hawke, S., Olsson, T., Fredrikson, S. and Link, H. T cell responses to human recombinant acetylcholine receptor-alpha subunit inmyasthenia gravis and controls. Eur. J. Immunol. 1992; 22: 1553-1559.
26. Tary Lehmann, M. and Saxon, A. Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J. Exp. Med. 1992; 175: 503-516.
27. Abedi, M.R., Christensson, B., Islam, K.B., Hammarstrom L. and Smith, C.I. Immunoglobulin production in severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood mononuclear cells. Eur. J. Immunol. 1992; 22: 823-828.
28. Mosier, D.E., Baird, S.M., Kirven, M.B., Gulizia, R.J., Wilson, D.B., Kubayashi, R., Picchio, G., Garnier, J.L., Sullivan, J.L. and Kipps, T.J. EBV-associated B-cell lymphomas following transfer of human peripheral blood lymphocytes to mice with severe combined immune deficiency. Curr. Top. Microbiol. Immunol. 1990; 166: 317-323.
29. Okano, M., Taguchi, Y., Nakamine, H., Pirruccello, S.J., Davis, J.R., Beisel, K.W., Kleveland, K.L., Sanger, W.G., Fordyce, R.R. and Purtilo, D.T. Characterization of Epstein-Barr virus-induced lymphoproliferation derived from human peripheral blood mononuclear cells transferred to severe combined immunodeficient mice. Am. J. Pathol. 1990; 137: 517-522.
30. Murphy, W.J., Taub, D.D. and Longo, D.L. The huPBL-SCID mouse as a means to examine human immune function in vivo. Semin. Immunol. 1996; 8: 233-241.
31. Yoshikawa, H. and Lennon, V.A. Acetylcholine receptor autoantibody secretion by thymocytes: relationship to myasthenia gravis. Neurology 1997; 49: 562-567.
32. Saxon, A., Macy, E., Denis, K., Tary Lehmann, M., Witte, O. and Braun, J. Limited B-cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans. J. Clin. Invest. 1991; 87: 658-665.