Autonomic control of heart rate in dogs treated chronically with morphine

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 6 44-6, 1998, Pages

  Napier, Leslie D ^a   Stanfill, Amber ^a   Yoshishige, Darice A ^a   Jackson, Keith E ^a   Barron, Barbara A ^a   Caffrey, James L ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Catecholamines; Intrinsic heart rate; Opiates; Parasympathetic nervous system; Power spectral analysis

Indexed keywords

ACETYLCHOLINE; MORPHINE;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR AUTOREGULATION; CHRONIC PAIN; CONTROLLED STUDY; DOG; HEART RATE; NEUROMODULATION; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; VAGUS NERVE STIMULATION;

EID: 0032417191     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.6.h2199     Document Type: Article

References (48)

1. Akselrod, S., D. Gordon, F. A. Ubel, D. C. Shannon, A. C. Barger, and R. J. Cohen. Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science 213: 220-222, 1981.
2. Barron, B. A., L. X. Oakford, J. F. Gaugl, and J. L. Caffrey. Methionine-enkephalin-Arg-Phe immunoreactivity in heart tissue. Peptides 16: 1221-1227, 1995.
3. Bornstein, J. C., and H. L. Fields. Morphine presynaptically inhibits a ganglionic cholinergic synapse. Neurosci. Lett. 15: 77-82, 1979.
4. Brunsting, J. R., H. A. Schuil, and W. G. Zijlstra. Intrinsic heart rate in the dog determined by pharmacological denervation. Am. J. Physiol. 245 (Heart Circ. Physiol. 14): H592-H597, 1983.
5. Casamenti, F., F. Pedata, R. Corradetti, and G. Pepeu. Acetylcholine output from the cerebral cortex, choline uptake and muscarinic receptors in morphine-dependent, freely-moving rats. Neuropharmacology 19: 597-605, 1980.
6. Clausen, T. G. International opioid consumption. Acta Anaesthesiol. Scand. 41: 162-165, 1997.
7. Darke, S., and D. Zador. Fatal heroin 'overdose': a review. Addiction 91: 1765-1772, 1996.
8. De Silva, R. A., R. L. Verrier, and B. Lown. Effect of morphine sulfate on vulnerability of the canine ventricle (Abstract). Clin. Res. 24: 214A, 1976.
9. De Silva, R. A., R. L. Verrier, and B. Lown. The effects of physiological stress and vagal stimulation with morphine on vulnerability to ventricular fibrillation (VF) in the conscious dog. Am. Heart J. 95: 197-203, 1978.
10. Evans, J. M., D. C. Randall, J. N. Funk, and C. F. Knapp. Influence of cardiac innervation on intrinsic heart rate in dogs. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H1132-H1137, 1990.
11. Fredrickson, R. C. A., and C. Pinsky. Morphine impairs acetylcholine release but facilitates acetylcholine action at a skeletal neuromuscular junction. Nature 231: 93-94, 1971.
12. Gross, N. J. Ipratropium bromide. N. Engl. J. Med. 319: 486-494, 1988.
13. Hotvedt, R., and H. Refsum. Cardiac effects of thoracic epidural morphine caused by increased vagal activity in the dog. Acta Anaesthesiol. Scand. 30: 76-83, 1986.
14. Hughes, P. H., and O. Rieche. Heroin epidemics revisited. Epidemiol. Rev. 17: 66-73, 1995.
15. Hughson, R. L., J. R. Sutton, J. D. Fitzgerald, and N. L. Jones. Reduction of intrinsic sinoatrial frequency and norepinephrine response of the exercised rat. Can. J. Physiol. Pharmacol. 55: 813-820, 1977.
16. Jhamandas, K., and M. Sutak. Modification of brain acetylcholine release by morphine and its antagonists in normal and morphine-dependent rats. Br. J. Pharmacol. 50: 57-62, 1974.
17. Jose, A. D., and F. Stitt. The effects of hypoxia and metabolic inhibitors on the intrinsic heart rate and myocardial contractility in dogs. Circ. Res. 25: 53-66, 1969.
18. Kennedy, B. L., and T. C. West. Effect of morphine on electrically-induced release of autonomic mediators in the rabbit sinoatrial node. J. Pharmacol. Exp. Ther. 157: 149-158, 1967.
19. Kleiger, R. E., J. P. Miller, J. T. Bigger, and A. J. Moss. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am. J. Cardiol. 59: 256-262, 1987.
20. Kosterlitz, H. W., and D. W. Taylor. The effect of morphine on vagal inhibition of the heart. Br. J. Pharmacol. Chemother. 14: 209-214, 1959.
21. Kuo, T. B. J., and S. H. H. Chan. Continuous, on-line, real-time spectral analysis of systemic arterial pressure signals. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H2208-H2213, 1993.
22. Labrecque, G., and E. F. Domino. Tolerance and physical dependence on morphine: relation to neocortical acetylcholine release in the cat. J. Pharmacol. Exp. Ther. 191: 189-200, 1974.
23. Lee, T. Y., M. J. Fu, T. B. J. Kuo, P. W. Lui, and S. H. H. Chan. Power spectral analysis of electromyographic and systemic arterial pressure signals during fentanyl-induced muscular rigidity in the rat. Br. J. Anaesth. 72: 328-334, 1994.
24. Leung, C. M., S. Dai, and C. W. Ogle. Arterial catecholamine levels in morphine-treated rats subjected to sympathetic nerve stimulation. Br. J. Pharmacol. 96: 888-894, 1989.
25. Leung, C. M., S. Dai, and C. W. Ogle. Changes in preganglionic sympathetic nerve function following chronic morphine treatment in rats. Br. J. Pharmacol. 99: 247-252, 1990.
26. Lewis, S. F., E. Nylander, P. Gad, and N. Areskog. Nonautonomic component in bradycardia of endurance trained men at rest and during exercise. Acta Physiol. Scand. 109: 297-305, 1980.
27. Lipsky, J., B. Stimmel, and E. Donoso. The effect of heroin and multiple drug abuse on the electrocardiogram. Am. Heart J. 86: 663-668, 1973.
28. Malik, M., and A. J. Camm. Components of heart rate variability: what they really mean and what we really measure. Am. J. Cardiol. 72: 821-822, 1993.
29. 14-methyl labeled morphine. I. In central nervous system of nontolerant and tolerant dogs. J. Pharmacol. Exp. Ther. 136: 232-241, 1962.
30. 14-methyl labeled morphine. II. Effect of nalorphine in the central nervous system of nontolerant dogs and observations on metabolism. J. Pharmacol. Exp. Ther. 136: 242-249, 1962.
31. Mullin, W. J., and J. W. Phillis. Acetylcholine release from the brain of unanaesthetized cats following habituation to morphine and during precipitation of the abstinence syndrome. Psychopharmacology (Berl.) 36: 85-99, 1974.
32. Musha, T., E. Satoh, H. Koyanagawa, T. Kimura, and S. Satoh. Effects of opioid agonists on sympathetic and parasympathetic transmission to the dog heart. J. Pharmacol. Exp. Ther. 250: 1087-1091, 1989.
33. Napier, L. D., Z. Mateo, D. A. Yoshishige, B. A. Barron, and J. L. Caffrey. Development of a large animal model of opiate addiction to evaluate cardiovascular function. Analgesia 1: 561-565, 1995.
34. Negrao, C. E., E. D. Moreira, M. C. L. Santos, V. M. A. Farah, and E. M. Krieger. Vagal function impairment after exercise training. J. Appl. Physiol. 72: 1749-1753, 1992.
35. Pagani, M., F. Lombardi, S. Guzzetti, O. Rimoldi, R. Furlan, P. Pizzinelli, G., Sandrone, G. Malfatto, S. Dell'Orto, E. Piccaluga, M. Turiel, G. Baselli, S. Cerutti, and A. Malliani. Power spectral analysis of heart rate, and arterial pressure variabilities as a marker of sympatho-vagal interaction in man, and conscious dog. Circ. Res. 59: 178-193, 1986.
36. Pur-Shahriari, A. A., R. A. Mills, F. G. Hoppin, Jr., and L. Dexter. Comparison of chronic and acute effects of morphine sulfate on cardiovascular function. Am. J. Cardiol. 20: 654-659, 1967.
37. Randich, A., C. L. Thurston, P. S. Ludwig, J. D. Robertson, and C. Rasmussen. Intravenous morphine-induced activation of vagal afferents: peripheral, spinal and CNS substrates mediating inhibition of spinal nociception and cardiovascular responses. J. Neurophysiol. 68: 1027-1045, 1992.
38. Randich, A., C. L. Thurston, P. S. Ludwig, M. R. Timmerman, and G. F. Gebhart. Antinociception and cardiovascular responses produced by intravenous morphine: the role of vagal afferents. Brain Res. 543: 256-270, 1991.
39. Rigel, D. F. Effects of neuropeptides on heart rate in dogs: comparison of VIP, PHI, NPY, CGRP, and NT. Am. J. Physiol. 255 (Heart Circ. Physiol. 24): H311-H317, 1988.
40. Rigel, D. F., D. Lipson, and P. G. Katona. Excess tachycardia: heart rate after antimuscarinic agents in conscious dogs. Am. J. Physiol. 246 (Heart Circ. Physiol. 15): H168-H173, 1984.
41. Saul, J. P. Beat-to-beat variations of heart rate reflect modulation of cardiac autonomic outflow. News Physiol. Sci. 5: 32-37, 1990.
42. Schaumann, W. Inhibition by morphine of the release of acetylcholine from intestine of the guinea pig. Br. J. Pharmacol. 12: 115-118, 1957.
43. Schuil, H. A., J. R. Brunsting, H. Van der Molen, and W. G. Zijlstra. Cardioacceleratory effect of muscarinic blocking agents in the dog. Eur. J. Pharmacol. 69: 229-233, 1981.
44. 14C-acetylcholine from the rat brain cortex slices. J. Pharm. Pharmacol. 21: 546-547, 1969.
45. Torda, C., and H. G. Wolff. Effect of convulsant and anticonvulsant agents on acetylcholine metabolism (activity of choline acetylase, cholinesterase) and on sensitivity to acetylcholine of effector organs. Am. J. Physiol. 151: 345-353, 1947.
46. Vicenzi, M. N., H. J. Woehlck, M. Boban, B. McCallum, J. L. Atlee, and Z. J. Bosnjak. Muscarinic and ganglionic blocking properties of atropine compounds in vivo and in vitro: time dependence and heart rate effects. Can. J. Physiol. Pharmacol. 73: 483-490, 1995.
47. Weitzell, R., P. Illes, and K. Starke. Inhibition via opioid μ-and δ-receptors of vagal transmission in rabbit isolated heart. Naunyn Schmiedebergs Arch. Pharmacol. 328: 186-190, 1984.
48. Yoshimura, K., M. Horiuchi, M. Konishi, and K. Yamamoto. Physical dependence on morphine induced in dogs via the use of miniosmotic pumps. J. Pharmacol. Toxicol. Methods 30: 85-95, 1993.