Effects of growth hormone treatment on serum levels of insulin-like growth factors (IGFs) and IGF binding proteins 1-4 in postmenopausal women

Clinical Endocrinology

Volumn 49, Issue 6, 1998, Pages 747-756

  Kassem, M ^a   Brixen, Kim ^a   Mosekilde, L ^a   Blum, W F ^b   Flyvbjerg, A ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; SOMATOMEDIN BINDING PROTEIN;

ADULT; AGED; ARTICLE; BLOOD LEVEL; BONE MASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HORMONAL THERAPY; HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

AGED; CALCITRIOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; POSTMENOPAUSE; REGRESSION ANALYSIS; SOMATOMEDINS; TRIIODOTHYRONINE;

EID: 0032417074     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1998.00606.x     Document Type: Article

References (53)

1. Angervo, M., Tiihonen, M., Leinonen, P., Valimaki, M. & Seppala, M. (1993) Thyroxine treatment increases circulating levels of insulin-like growth factor binding protein-1: a placebo-controlled study. Clinical Endocrinology, 38, 547-551.
2. Bang, P., Degerblad, M., Thoren, M., Schwander, J., Blum, W. & Hall, K. (1993) Insulin-like growth factor (IGF) I and II and IGF binding protein (IGFBP) 1, 2 and 3 in serum from patients with Cushing's syndrome. Acta Endocrinology (Copenhagen), 128, 397-104.
3. Benedict, M.R., Lu, M.J., Florini, J.R., Woo, J. & Richman, R.A. (1994) The differential regulation of insulin-like growth factor (IGF) binding proteins by IGF-I during the life span of the rat. Journal of Gerontology, 49, B215-223.
4. Binkert, C., Landwehr, J., Mary, J.L., Schwander, J. & Heinrich, G. (1989) Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2). EMBO Journal, 8, 2497-2502.
5. Blum, W.F., Ranke, M.B. & Bierich, J.R. (1988) A specific radioimmunoassay for insulin-like growth factor II: The interference of IGF binding proteins can be blocked by excess IGF-I. Acta Endocrinologica (Copenhagen), 118, 374-380.
6. Blum, W.F., Jenne, E.W., Reppin, F., Kietzmann, K., Ranke, M.B. & Bierich, J.R. (1989) Insulin-like growth factor-I (IGF-I)-binding protein complex is a better mitogen than free IGF-I. Endocrinology, 125, 766-772.
7. Blum, W.F., Ranke, M.B., Kietzmann, K., Gauggel, E., Zeisel, H.J. & Bierich, J.R. (1990) A specific radioimmunoassay for the growth hormone (GH) dependent somatomedin-binding protein: Its use for the diagnosis of GH deficiency. Journal of Clinical Endocrinology and Metabolism, 70, 1292-1298.
8. Blum, W.F., Hall, K., Ranke, M.B. & Wilton, P. (1993) Growth hormone insensitivity syndromes: a preliminary report on changes in insulin-like growth factors and their binding proteins during treatment with recombinant insulin-like growth factor I. Kabi Pharmacia Study Group on Insulin-like Growth Factor I Treatment in Growth Hormone Insensitivity Syndromes. Acta Paediatrica, 82 Suppl 391, 15-19.
9. Brixen, K., Nielsen, H.K., Mosekilde, L. & Flyvbjerg, A. (1990) A short course of recombinant human growth hormone treatment stimulates osteoblasts and activates bone remodeling in normal human volunteers. Journal of Bone and Mineral Research, 5, 609-619.
10. Brixen, K., Kassem, M., Nielsen, H.K., Flyvbjerg, A., Loft, A.G. & Mosekilde, L. (1995) Short-term treatment with growth hormone stimulates osteoblastic and osteoclastic activity in osteopenic post-menopausal women; a dose response study. Journal of Bone and Mineral Research, 10, 1865-1875.
11. Conover, C.A., Butler, P.C., Wang, M., Rizza, R.A. & Lee, P.D. (1990) Lack of growth hormone effect on insulin-associated suppression of insulinlike growth factor binding protein 1 in humans. Diabetes, 39, 1251-1256.
12. Coulson, V.J., Wass, J.A., Abdulla, A.F., Cotterill, A.M. & Holly, J.M. (1991) Insulin-like growth factor binding proteins (IGFBPs) in acromegaly. Growth Regulation, 1, 119-124.
13. Fielder, P.J., Guevara Aguirre, J., Rosenbloom, A.L., Carlsson, L., Hintz, R.L. & Rosenfeld, R.G. (1992) Expression of serum insulin-like growth factors, insulin-like growth factor-binding proteins, and the growth hormone-binding protein in heterozygote relatives of Ecuadorian growth hormone receptor deficient patients. Journal of Clinical Endocrinology and Metabolism, 74, 743-750.
14. Flyvbjerg, A., Kessler, U., Dorka, B., Funk, B., Ørskov, H. & Kiess, W. (1992) Transient increase in renal insulin-like growth factor binding proteins during initial kidney hypertrophy in experimental diabetes in rats. Diabetologia, 35, 589-593.
15. Gargosky, S.E., Hasegawa, T., Tapanainen, P., Macgillivray, M., Hasegawa, Y. & Rosenfeld, R.G. (1993) Urinary insulin-like growth factors (IGF) and IGF-binding proteins in normal subjects, growth hormone deficiency, and renal disease. Journal of Clinical Endocrinology and Metabolism, 76, 1631-1637.
16. Glantschnig, H., Varga, F. & Klaushofer, K. (1996) Thyroid hormone and retinoic acid induce the synthesis of insulin-like growth factor-binding protein-4 in mouse osteoblastic cells. Endocrinology, 137, 281-286.
17. Gosteli Peter, M.A., Winterhalter, K.H., Schmid, C., Froesch, E.R. & Zapf, J. (1994) Expression and regulation of insulin-like growth factor-1 (IGF-1) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone. Endocrinology, 135, 2558-2567.
18. Gourmelen, M., Perin, L. & Binoux, M. (1991) Effects of exogenous insulin-like growth factor I on insulin-like growth factor binding proteins in a case of growth hormone insensitivity (Laron-type). Acta Paediatrica Scandinavica Suppl., 377, 115-117.
19. Holloway, L., Butterfield, G., Hintz, R.L., Gesundheit, N. & Marcus, R. (1994) Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women. Journal of Clinical Endocrinology and Metabolism, 79, 470-479.
20. Honda, Y., Landale, E.C., Strong, D.D., Baylink, D.J. & Mohan, S. (1996) Recombinant synthesis of insulin-like growth factor-binding protein-4 (IGFBP-4): Development, validation, and application of a radioimmunoassay for IGFBP-4 in human serum and other biological fluids. Journal of Clinical Endocrinology and Metabolism, 81, 1389-1396.
21. Hossenlopp, P., Seurin, D., Segovia Quinson, B., Hardouin, S. & Binoux, M. (1986) Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of the method for titration of the binding proteins and competitive binding studies. Analytical Biochemistry, 154, 138-143.
22. Jones, J.I. & Clemmons, D.R. (1995) Insulin-like growth factors and their binding proteins: Biological actions. Endocrine Reviews, 16, 3-34.
23. Jorgensen, J.O., Blum, W.F., Moller, N., Ranke, M.B. & Christiansen, J.S. (1991) Short-term changes in serum insulin-like growth factors (IGF) and IGF binding protein 3 after different modes of intravenous growth hormone (GH) exposure in GH-deficient patients. Journal of Clinical Endocrinology and Metabolism, 72, 582-587.
24. Jorgensen, J.O., Pedersen, S.B., Borglum, J., Frystyk, J., Ho, K.K., Christiansen, J.S., Orskov, H., Blum, W.F. & Richelsen, B. (1995) Serum concentrations of insulin-like growth factors (IGFs), IGF binding proteins 1 and 3 and growth hormone binding protein in obese women and the effects of growth hormone administration: a double-blind, placebo-controlled study. European Journal of Endocrinology, 133, 65-70.
25. Kassem, M., Brixen, K., Blum, W., Mosekilde, L. & Eriksen, E.F. (1994) No evidence for reduced spontaneous or growth-hormone-stimulated serum levels of insulin-like growth factor (IGF)-I, IGF-II or IGF binding protein 3 in women with spinal osteoporosis. European Journal of Endocrinology, 131, 150-155.
26. Kassem, M., Okazaki, R., De Leon, D., Harris, S.A., Robinson, J.A., Spelsberg, T.C., Conover, C.A. & Riggs, B.L. (1996) Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4. Proceedings of the Association of American Physicians, 108, 155-164.
27. Kiefer, M.C., Schmid, C., Waldvogel, M., Schlapfer, I., Futo, E., Masiarz, F.R., Green, K., Barr, P.J. & Zapf, J. (1992) Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast. Journal of Biological Chemistry, 267, 12692-12699.
28. Kiefer, M.C., Schmid, C., Waldvogel, M., Schlapfer, I., Futo, E., Masiarz, F.R., Green, K., Barr, P.J. & Zapf, J. (1993) Recombinant human insulin-like growth factor binding proteins 4, 5, and 6: biological and physiochemical characterization. Growth Regulation, 3, 56-59.
29. LaTour, D., Mohan, S., Linkhart, T.A., Baylink, D.J. & Strong, D.D. (1990) Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation. Molecular Endocrinology, 4, 1806-1814.
30. Mohan, S., Nakao, Y., Honda, Y., Landale, E., Leser, U., Dony, C., Lang, K. & Baylink, D.J. (1995) Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells. Journal of Biological Chemistry, 270, 20424-20431.
31. Mohan, S. & Baylink, D.J. (1996) Insulin-like growth factor (IGF)-binding proteins in serum. Do they have additional roles besides modulating the endocrine IGF actions? Journal of Clinical Endocrinology and Metabolism, 81, 3817-3819.
32. Mosekilde, L., Charles, P. & Lindegreen, P. (1989) Determinants for serum 1,25-dihydroxycholecalciferol in primary hyperparathyroidism. Bone and Mineral, 5, 279-290.
33. Nanto Salonen, K. & Rosenfeld, R.G. (1992) Insulin-like growth factor binding protein expression in the hypothyroid rat is age dependent. Endocrinology, 131, 1489-1496.
34. Nanto Salonen, K., Muller, H.L., Hoffman, A.R., Vu, T.H. & Rosenfeld, R.G. (1993) Mechanisms of thyroid hormone action on the insulin-like growth factor system: all thyroid hormone effects are not growth hormone mediated. Endocrinology, 132, 781-788.
35. Rutanen, E., Kärkkäinen, T., Stenman, U. & Yki-Järvinen, H. (1993) Aging is associated with decreased suppression of insulin-like growth factor binding protein-1 by insulin. Journal of Clinical Endocrinology and Metabolism, 77, 1152-1155.
36. Saggese, G., Federico, G. & Cinquanta, L. (1995) Plasma growth hormone-binding protein activity, insulin-like growth factor 1, and its binding protein levels in patients with Turner's syndrome: effect of short- and long-term recombinant human growth hormone administration. Pediatric Research, 37, 106-111.
37. Scharla, S.H., Strong, D.D., Mohan, S., Baylink, D.J. & Linkhart, T.A. (1991) 1,25-Dihydroxyvitamin D3 differentially regulates the production of insulin-like growth factor I (IGF-I) and IGF-binding protein-4 in mouse osteoblasts. Endocrinology, 129, 3139-3146.
38. Scharla, S.U., Strong, D.D., Rosen, C., Mohan, S., Holick, M., Baylink, D.J. & Linkhart, T.A. (1993) 1,25-Dihydroxyvitamin D3 increases secretion of insulin-like growth factor binding protein-4 (IGFBP-4) by human osteoblast-like cells in vitro and elevates IGFBP-4 serum levels in vivo. Journal of Clinical Endocrinology and Metabolism, 77, 1190-1197.
39. Schmid, C., Schlapfer, I., Waldvogel, M., Meier, P.J., Schwander, J., Boni Schnetzler, M., Zapf, J. & Froesch, E.R. (1992) Differential regulation of insulin-like growth factor binding protein (IGFBP)-2 mRNA in liver and bone cells by insulin and retinoic acid in vitro. FEBS Letters, 303, 205-209.
40. Schwander, J. & Mary, J.L. (1993) the RIA for IGFBP-2 in man - a meagre catch? Growth Regulation, 3, 104-108.
41. Shimasaki, S. & Ling, N. (1991) Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5, -6). Progress in Growth Factor Research, 3, 243-266.
42. Shishko, P.I., Dreval, A.V., Abugova, I.A., Zajarny, I.U. & Goncharov, V.C. (1994) Insulin-like growth factors and binding proteins in patients with recent-onset type 1 (insulin-dependent) diabetes mellitus: influence of diabetes control and intraportal insulin infusion. Diabetes Research and Clinical Practice, 25, 1-12.
43. Suikkari, A., Maclachlan, V., Koistinen, R., Seppala, M. & Healy, D. (1996) Double-blind placebo controlled study: human biosynthetic growth hormone for assisted reproductive technology. Fertility and Sterility, 65, 800-805.
44. Thompson, J.L., Butterfield, G.E., Marcus, R., Hintz, R.L., Van Loan, M.. Ghiron, L. & Hoffman, A.R. (1995) The effects of recombinant human insulin-like growth factor-1 and growth hormone on body composition in elderly women. Journal of Clinical Endocrinology and Metabolism, 80, 1845-1852.
45. Unterman, T.G. (1993) Insulin-like growth factor binding protein-1: identification purification, and regulation in fetal and adult life. Advances in Experimental Medicine and Biology 343, 215-226.
46. 125I-monolabeled 3,5,3′-triiodothyronine and thyroxine of maximum specific activity for radioimmunoassay. Scandinavian Journal of Clinical Investigation, 32, 357-360.
47. White, M.E., Leaman, D.W., Ramsay, T.G., Kampman, K.A., Ernst, C.W. & Osborne, J.M. (1993) Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa). Comparative Biochemistry and Physiology B, 106, 341-347.
48. Wilson, E.M., Oh, Y. & Rosenfeld, R.G. (1997) Generation and characterisation of an IGFBP-7 antibody; identification of 31kD IGFBP-7 in human biological fluids and Hs578T human breast cancer conditioned media. Journal of Clinical Endocrinology and Metabolism, 82, 1301-1303.
49. Wolf, E., Kramer, R., Blum, W.F., Foll, J. & Brem, G. (1994) Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth. Endocrinology, 135, 1877-1886.
50. Young, S.C., Underwood, L.E., Celniker, A. & Clemmons, D.R. (1992) Effects of recombinant insulin-like growth factor-I (IGF-I) and growth hormone on serum IGF-binding proteins in calorically restricted adults. Journal of Clinical Endocrinology and Metabolism, 75, 603-608.
51. Youngman, O., Yamanaka, Y., Wilson, E., Kim, H.S., Vorwerk, P., Hwa, V., Yang, D.H., Wanek, D. & Rosenfeld, R.G. (1997) IGF-dependent actions of IGFBP: New concepts for their role in growth regulation. Hormone Research, 48, 3 (Abstract).
52. Zapf, J., Schmid, C., Guler, H.P., Waldvogel, M., Hauri, C., Futo, E., Hossenlopp, P., Binoux, M. & Froesch, E.R. (1990) Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia. Journal of Clinical Investigation, 86, 952-961.
53. Orskov, H., Thomsen, A.G. & Yde, H. (1968) Wick-chromatography for rapid and reliable immunoassay of insulin, glucagon, and growth hormone, Nature, 219, 193-195.