Limiting dilution analysis of peripheral blood lymphocytes reacting with non-small-cell lung cancer: Functionally heterogeneous effectors efficiently lyse autologous cancer cells

Lung Cancer

Volumn 21, Issue 1, 1998, Pages 27-36

  Semino, Claudia ^a   Cilli, Michele ^b   Battista Ratto, Giovanni ^c   Deng, Weiwen ^a   Pietra, Gabriella ^a   Cangemi, Giuliana ^a   Melioli, Giovanni ^a  

^a Laboratorio Patologia Clinica   (Italy)

^b Ctro Biotecnologie Avanzate I   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

Apoptosis; Cytokine secretion; Natural killer cells; Non small cell lung cancer; Specific cytolytic lymphocytes

Indexed keywords

CYTOKINE; GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR;

ADOPTIVE IMMUNOTHERAPY; ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; HLA TYPING; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; TUMOR ASSOCIATED LEUKOCYTE;

AGED; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CYTOKINES; HUMANS; INDICATOR DILUTION TECHNIQUES; LUNG NEOPLASMS; LYMPHOCYTES; MALE; MICE; MICE, SCID; MIDDLE AGED; TUMOR CELLS, CULTURED;

EID: 0032416838     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-5002(98)00041-5     Document Type: Article

References (15)

1. Ratto GB, Melioli G, Zino P, Mereu C, Mirabelli S, Fantino G, Ponte M, Minuti P, Verna A, Noceti P, Tassara E, Rovida S Immunotherapy using tumor-infiltrating lymphocytes and interleukin-2 as adjuvant treatment in stage III non-small-cell lung cancer. A pilot study. J Thorac Cardiovasc Surg. 105:1995;1212-1217.
2. Melioli G, Ratto GB, Ponte M, Guastella M, Semino C, Fantino G, Tassara E, Pasquetti W, Mereu C, Merlo F, Reggiardo G, Morasso G, Santi L, Moretta L Treatment of Stage IIIb non small cell lung cancer with surgery followed by infusion of tumor infiltrating lymphocytes and recombinant interleukin-2: a pilot study. J Immunother. 19:1996;224-230.
3. Ratto GB, Zino P, Mirabelli S, Minuti P, Acquilina R, Fantino G, Spessa E, Ponte M, Bruzzi P, Melioli G A randomized trial of adoptive immunotherapy with tumor infiltrating lymphocytes and interleukin-2 vs. standard therapy in the postoperative treatment of resected non-small-cell lung cancer. Cancer. 78:1996;244-251.
4. Meta M, Ponte M, Guastella M, Semino C, Pietra G, Ratto GB, Melioli G Detection of oligoclonal T lymphocytes in lymph nodes draining from advanced non-small-cell lung cancer. Cancer Immunol Immunother. 40:1995;235-240.
5. Melioli G, Ratto GB, Guastella M, Meta M, Biassoni R, Semino C, Casartelli GL, Pasquetti W, Catrullo A, Moretta L Isolation and in vitro expansion of lymphocytes infiltrating non-small cell lung carcinoma: functional and molecular characterization for their use in adoptive immunotherapy. Eur J Cancer. 30:1994;97-102.
6. Wölfel T, Klehmann E, Müller C, Schütt KH, Meyer zum Büschenfelde KH, Knuth A Lysis of human melanoma cells by autologous cytolytic T cell clones. Identification of human histocompatibility leukocyte antigen A2 as a restriction element for three different antigens. J Exp Med. 3:1989;797-810.
7. Sensi M, Salvi S, Castelli C, Maccalli C, Mazzocchi A, Mortarini R, Nicolini G, Herlyn M, Parmiani G, Anichini A T cell receptor (TCR) structure of autologous melanoma-reactive cytotoxic T lymphocyte (CTL) clones: tumor-infiltrating lymphocytes overexpress in vivo the TCR beta chain sequence used by an HLA-A2-restricted and melanocyte-lineage-specific CTL clone. J Exp Med. 4:1993;1231-1246.
8. Melioli G, Guastella M, Semino C, Meta M, Pietra G, Ponte M, Queirolo P, Sertoli MR, Martini L, Reali UM Proliferative, phenotypic, functional and molecular characteristics of tumor infiltating lymphocytes, obtained from unselected patients with malignant melanomas and expanded in vitro in the presence of rIL-2. Melanoma Res. 4:1994;127-133.
9. Melioli G, Ferrari I, Casartelli G, Ragni N Lymphocytes isolated from the peritoneal fluid of patients with advanced ovarian carcinoma differ significantly from autologous peripheral blood lymphocytes. Gynecol Oncol. 48:1993;301-307.
10. Semino C, Semino A, Pietra G, Mingari MC, Barocci S, Venturini PL, Ragni N, Melioli G Role of major histocompatibility complex (MHC) class I expression and natural killer-like T cells in the genetic control of endometriosis. Fertil Steril. 64:1995;909-916.
11. Taswell C Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Date analysis. J Immunol. 126:1981;1614-1620.
12. Ciccone E, Pende D, Vitale M, Nanni L, Di Donato L, Bottino C, Morelli L, Viale O, Amoroso A, Moretta A, Moretta L Self class I molecules protect normal cells from lysis mediated by autologous natural killer cells. Eur J Immunol. 24:1994;1003-1006.
13. Mingari MC, Vitale C, Cambiaggi A, Schiavetti F, Melioli G, Ferrini S, Moretta A Cytolytic T lymphocytes displaying natural killer(NK)-like activity. Expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int Immunol. 7:1995;697-703.
14. Terasaki PI, McClelland JD Microdroplet of human serum cytotoxine. Nature. 204:1964;998-1000.
15. van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T A gene encoding an antigen recognized by cytolitic T lymphocytes on a human melanoma. Science. 254:1991;1643-1647.