Mechanisms of spontaneous activity in the developing spinal cord and their relevance to locomotion

Annals of the New York Academy of Sciences

Volumn 860, Issue , 1998, Pages 130-141

  O'Donovan, Michael J ^a,c   Wenner, P ^a   Chub, N ^a   Tabak, J ^a   Rinzel, J ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; CHICK EMBRYO; CONFERENCE PAPER; CONTROLLED STUDY; DEPOLARIZATION; EMBRYO; INTERNEURON; LATENT PERIOD; LOCOMOTION; LUMBAR SPINAL CORD; MOTONEURON; MUSCLE INNERVATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; SACRAL SPINAL CORD; SARTORIUS MUSCLE; SPINAL CORD; STIMULATION; SYNAPTIC TRANSMISSION; TIBIALIS ANTERIOR MUSCLE; VENTRAL ROOT;

ANIMALIA;

EID: 0032414917     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb09044.x     Document Type: Conference Paper

References (33)

1. 1. Bekoff, A. 1976. Ontogeny of leg motor output in the chick embryo: A neural analysis. Brain Res. 106: 271-291.
2. 2. O'Donovan, M. J. 1989. Motor activity in the isolated spinal cord of the chick embryo: Synaptic drive and firing pattern of single motoneurons. J. Neurosci. 9: 943-958.
3. 3. Perret, C. 1983. Centrally generated pattern of motoneuron activity during locomotion in the cal. Symp. Soc. Exp. Biol. 37: 405-422.
4. 4. Orsal, D., C. Perret & J. M. Cabelguen. 1986. Evidence of rhythmic inhibitory synaptic influences in hindlimb motoneurons during fictive locomotion in the thalamic cat. Exp. Brain Res. 64: 217-224.
5. 5. Sernagor, E. & M. J. O'Donovan. 1991. Whole cell patch clamp of rhythmically active motoneurons in the isolated spinal cord of the chick embryo. Neurosci. Lett. 128: 211-216.
6. 6. Sernagor, E., N. Chub, A. Ritter & M. J. O'Donovan. 1995. Pharmacological characterization of the rhythmic synaptic drive onto lumbosacral motoneurons in the chick embryo spinal cord. J. Neuroscience 15: 7452-7464.
7. 7. Chub, N. & M. J. O'Donovan. 1998. Blockade and recovery of spontaneous rhythmic activity following application of neurotransmitter antagonists to spinal networks of the chick embryo. J. Neuroscience 18: 294-306.
8. 8. Obata, K., M. Oide & H. Tanaka. 1978. Excitatory and inhibitory actions of glycine on embryonic chick spinal neurons in culture. Brain Res. 144: 179-184.
9. 9. Wu, W., L. Ziskind-Cunhaim & M. A. Sweet. 1992. Early development of glycine-and GABA-mediated synapses in rat spinal cord. J. Neurosci. 12: 3935-3945.
10. 10. Nishimaru, H., M. Iizuka, S. Ozaki & N. Kudo. 1996. Spontaneous motoneuronal activity mediated by glycine and GABA in the spinal cord of rat fetuses in vitro. J. Physiol. 497: 131-143.
11. 11. Ho, S. & M. J. O'Donovan. 1993. Regionalization and inter-segmental coordination of rhythm generating networks in the spinal cord of the chick embryo. J. Neurosci. 13: 1345-1371.
12. 12. Wenner, P., M. Matise, A. Joyner & M. J. O'Donovan. 1998. Physiological and molecular characterization of interneurons in the developing spinal cord. Ann. N. Y. Acad. Sci. This volume.
13. 13. Wenner, P., M. Matise & M. J. O'Donovan. 1997. Physiological and molecular characterization of interneurons in the developing spinal cord. Soc. Neurosci. Abstr. 23: 1978.
14. 14. Antal, M., A. Cs. Berki, L. Horvath & M. J. O'Donovan. 1994. Developmental changes in the distribution of GABA-immunoreactive neurons in the embryonic chick lumbosacral spinal cord. J. Comp. Neurol. 341: 1-9.
15. 15. Ma, W., T. Behar & J. L. Barker. 1992. Transient expression of GABA immunoreactivity in the developing rat spinal cord. J. Comp. Neurol. 325: 271-290.
16. 16. Berki, A. C., M. J. O'Donovan & M. Antal. 1995. Developmental expression of glycineimmunoreactivity and its colocalization with GABA in the embryonic chick lumbosacral spinal cord. J. Comp. Neurol. 363: 1-14.
17. 17. Kotak, V. C., S. Korada, I. R. Schwartz & D. H. Sanes. 1998. A developmental shift from GABAergic to glycinergic transmission in the central auditory system. J. Neurosci. 18: 4646-4655.
18. 18. O'Donovan, M. J. & N. Chub. 1997. Population behavior and self-organization in the genesis of spontaneous rhythmic activity by developing spinal networks. Semin. Cell Dev. Biol. 8: 21-28.
19. 19. O'Donovan, M. J., N. Chub & P. Wenner. 1998. Mechanisms of spontaneous activity in developing spinal networks. J. Neurobiol. In Press.
20. 20. Chub, N. & M. J. O'Donovan. 1995. Multi-functional actions of GABA in the regulation of spontaneous activity in the isolated spinal cord of the chick embryo. Soc. Neurosci. Abstr. 21: 688.
21. 21. Fedirchuk, B. & M. J. O'Donovan. 1996. Evoked potentials are transiently depressed following rhythmic activity in the embryonic chick spinal cord. Soc. Neurosci. Abstr. 22: 1377
22. 22. Chub, N., L. E. Moore & M. J. O'Donovan. 1997. Comparison of NMDA-induced membrane potential oscillations and spontaneous rhythmic activity in the chick spinal cord. Soc. Neurosci. Abstr. 23: 1978.
23. 23. Chub, N., L. E. Moore & M. J. O'Donovan. 1997. Comparison of NMDA-induced membrane potential oscillations and spontaneous rhythmic activity in the chick spinal cord. Ann. N. Y. Acad. Sci. This volume.
24. 24. Rinzel, J. & M. J. O'Donovan. 1997. A model based on synaptic depression for population rhythmogenesis. Abstract for CNS*97 meeting.
25. 25. Senn, W., K. Wyler, J. Streit, M. Larkum, H-R. Luscher, H. Mey, L. Muller, D. Stainhauser, K. Vogt & Th. Wannier. 1996. Dynamics of a random neural network with synaptic depression. Neural Networks 9: 575-588.
26. 26. Streit, J., C. Luscher & H-R. Luscher. 1992. Depression of postsynaptic potentials by high-frequency stimulation in embryonic motoneurons grown in spinal cord slice cultures. J. Neurophysiol. 68: 1793-1803.
27. 27. Tabak, J. & M. J. O'Donovan. 1998. Statistical analysis and intersegmental delays reveal possible roles of network depression in the generation of spontaneous activity in the chick embryo spinal cord. Ann. N. Y. Acad. Sci. This volume.
28. 28. Barry, M. & M. J. O'Donovan. 1987. The effects of excitatory amino acids and their antagonists on the generation of motor activity in the isolated chick cord. Dev. Brain. Res. 36: 271-276.
29. 29. Wong, R. K., R. D. Traub & R. Miles. 1986. Cellular basis of neuronal synchrony in epilepsy. Adv. Neurol. 44: 583-592.
30. 30. Lev-Tov, A., M. J. Pinter & R. E. Burke. 1983. Posttetanic potentiation of group Ia EPSPs: Possible mechanisms for differential distribution among medial gastrocnemius motoneurons. J. Neurophysiol. 50: 379-398.
31. H receptor feed-back on GABA release. J. Physiol. 412: 513-541.
32. 32. Markram, H. & M. Tsodyks. 1996. Redistribution of synaptic efficacy between neocortical pyramidal neurons. Nature 882: 807-810.
33. 33. Maeda, E., H. P. Robinson & A. Kawana. 1995. The mechanisms of generation and propagation of synchronized bursting in developing networks of cortical neurons. J. Neurosci. 15: 6834-6845.