Vinculin but not α-actinin is a target of PKC phosphorylation during junctional assembly induced by calcium

Journal of Cell Science

Volumn 111, Issue 23, 1998, Pages 3563-3571

  Perez Moreno, M ^a   Avila, A ^a   Islas, S ^a   Sanchez, S ^a   Gonzalez Mariscal L ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

actinin; Calcium switch,; Junctional complex; MDCK; Phosphorylation; PKC; Vinculin

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ALPHA ACTININ; CALCIUM ION; CALPHOSTIN C; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN KINASE C; VINCULIN;

ARTICLE; CELL STRAIN; CELLULAR DISTRIBUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ACTININ; ANIMALS; BINDING SITES; CALCIUM; CELL LINE; DOGS; MICROSCOPY, FLUORESCENCE; PHOSPHORYLATION; PROTEIN KINASE C; SERINE; SUBCELLULAR FRACTIONS; THREONINE; TIGHT JUNCTIONS; VINCULIN;

EID: 0032413247     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Nieset, J. E., Redfield, A. R., Jin, F., Knudsen, K. A., Johnson, K. R. and Wheelock, M. J. (1997). Characterization of the interaction of α-catenin with α-actinin and β-catenin/plakoglobin. J. Cell Sci. 110, 1013-1022.
2. Nigam, S. K., Denisenko, N., Rodriguez-Boulan, E. and Citi, S. (1991). The role of phosphorylation in development of tight junctions in cultured renal epithelial MDCK cells. Biochem. Biophys. Res. Commun. 181, 548-553.
3. O'Keefe, E. J., Briggaman, R. A. and Herman, B. (1987). Calcium-induced assembly of adherens junctions in keratinocytes. J. Cell Biol. 105, 807-817.
4. Rodriguez-Fernandez, J. L., Geiger, B., Salomon, D., Sabanay, I., Zoller, M. and Ben-Ze'ev A. ( 1992). Suppression of tumorigenicity in transformed cells after transfection with vinculin cDNA. J. Cell Biol. 119, 427-438.
5. Samuels, M., Ezzell, R., Cardozo, T. J., Critchley, D. R., Coll, J. and Adamson, E. D. 1993. Expression of chicken vinculin complements the adhesion defective phenotype of a mutant mouse F9 embryonal carcinoma cell. J. Cell Biol. 121, 909-921.
6. Schwienbacher, C., Jockusch, B. M. and Rudiger, M. (1996). Intramolecular interactions regulate serine/threonine phosphorylation of vinculin. FEBS Lett. 384, 71-74.
7. Sefton, B. M., Hunter, T., Ball, E. H. and Singer, S. J. (1981). Vinculin: a cytoskeletal target of the transforming protein of the Rous Sarcoma virus. Cell 24, 165-174.
8. Stevenson, B. M. and Begg, D. A. (1994). Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells. J. Cell Sci. 107, 367-375.