Changes in neurotensin mRNA by estrogen in the female rat preoptic area during aging: An in situ hybridization histochemistry study

General and Comparative Endocrinology

Volumn 112, Issue 3, 1998, Pages 364-371

  Funabashi, Toshiya ^a   Kleopoulos, Steven P ^b   Kimura, Fukuko ^a   Mobbs, Charles V ^a,b  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Estrogen; In situ hybridization; LH surge; Neurotensin; Preoptic area

Indexed keywords

CHOLESTEROL; ESTROGEN; LUTEINIZING HORMONE; MESSENGER RNA; NEUROTENSIN;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CONTROLLED STUDY; ESTROGEN RELEASE; FEMALE; HISTOCHEMISTRY; HORMONE SENSITIVITY; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; IN SITU HYBRIDIZATION; LUTEINIZING HORMONE RELEASE; NONHUMAN; OVARIECTOMY; PREOPTIC AREA; PRIORITY JOURNAL; RAT; REPRODUCTION;

EID: 0032410589     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1006/gcen.1998.7139     Document Type: Article

References (33)

1. Akema T., Mitsugi N., Tadokoro Y., Kimura F. Differential changes in the mechanisms controlling luteinizing hormone and prolactin secretion in middle-aged female rats. Endocrinol Jpn. 32:1985;153-161.
2. Akema T., Praputpittaya C., Kimura F. Effects of preoptic microinjection of neurotensin on luteinizing hormone secretion in unanesthetized ovariectomized rats with or without estrogen priming. Neuroendocrinology. 46:1987;345-349.
3. Alexander M., Dobner P., Miller M., Bullock B., Dorsa D., Leeman S. Estrogen induces neurotensin/neuromedin N messenger ribonucleic acid in a preoptic nucleus essential for the preovulatory surge of luteinizing hormone in the rat. Endocrinology. 125:1989a;2111-2117.
4. Alexander M., Mahoney P., Ferris C., Carraway R., Leeman S. Evidence that neurotensin participates in the central regulation of the preovulatory surge of luteinizing hormone in the rat. Endocrinology. 124:1989b;783-788.
5. Alexander M. J., Kiraly Z. J., Leeman S. E. Sexually dimorphic distribution of neurotensin/neuromedin N mRNA in the rat preoptic area. J. Comp. Neurol. 311:1991;84-96.
6. Axelson J., Shannon W., Van Leeuwen F. Immunocytochemical localization of estrogen receptors within neurotensin cells in the rostral preoptic area of the rat hypothalamus. Neurosci. Lett. 136:1992;5-9.
7. Blaha G. C., Lamperti A. A. Estradiol target neurons in the hypothalamic arcuate nucleus and lateral ventromedial nucleus of young adult, reproductively senescent and monosodium glutamate-lesioned female golden hamsters. J. Gerontol. 38:1983;532-537.
8. Brooks P. J., Funabashi T., Kleopoulos S. P., Mobbs C. V., Pfaff D. W. Cell-specific expression of preproenkephalin intronic heteronuclear RNA in the rat forebrain. Mol. Brain Res. 19:1993;22-30.
9. Brown T. J., Maclusky N. J., Shanabrough M., Naftolin F. Comparison of age- and sex-related changes in cell nuclear estrogen-binding capacity and progestin receptor induction in the rat brain. Endocrinology. 126:1990;2965-2972.
10. Cooper R. L., Conn P. M., Walker R. F. Characterization of the LH surge in middle-aged female rats. Biol. Reprod. 23:1980;611-615.
11. Funabashi T., Kimura F. Effects of estrogen on estrogen receptor messenger RNA levels in young and middle-aged female rats: Comparison between medial preoptic area and mediobasal hypothalamus. Acta Biol. Hung. 45:1994;223-231.
12. Funabashi T., Brooks P. J., Kleopoulos S. P., Grandison L., Mobbs C. V., Pfaff D. W. Changes in preproenkephalin messenger RNA level in the rat ventromedial hypothalamus during the estrous cycle. Mol. Brain Res. 28:1995;129-134.
13. Funabashi T., Kimura F. The number of luteinizing hormone-releasing hormone immunoreactive neurons is significantly decreased in the fore brain of old-aged female rats. Neurosci. Lett. 189:1995;85-88.
14. Gray G. D., Tennent B., Smith E. R., Davidson J. M. Luteinizing hormone regulation and sexual behavior in middle-aged female rats. Endocrinology. 107:1980;187-194.
15. Herbison A., Theodosis D. Localization of oestrogen receptors in preoptic neurons containing neurotensin but not tyrosine hydroxylase, cholecystokinin or luteinizing hormone-releasing hormone in the male and female rat. Neuroscience. 50:1992;283-298.
16. Hoffman G. E. LHRH neurons in the female C57BL/6J mouse brain during reproductive aging: No loss up to middle age. Neurobiol. Aging. 7:1986;45-48.
17. 2. Gerontology. 27:1981;51-57.
18. Karelus K., Nelson J. F. Aging impairs estrogenic suppression of hypothalamic proopiomelanocortin messenger ribonucleic acid in the mouse. Neuroendocrinology. 55:1992;627-633.
19. Legan S. J., Karsch F. J. A daily signal for the LH surge in the rat. Endocrinology. 96:1975;57-62.
20. Lloyd J. M., Scarborough K., Weiland N. G., Wise P. M. Age-related changes in proopiomelanocorticotropin (POMC) gene expression in the periarcuate region of ovariectomized rats. Endocrinology. 129:1991;1896-1902.
21. Lloyd J. M., Hoffman G. E., Wise P. M. Decline in immediate early gene expression in gonadotropin-releasing hormone neurons during proestrus in regularly cycling, middle-aged rats. Endocrinology. 134:1994;1800-1805.
22. Lu J. H. K., Gilman D. P., Meldrum D. R., Judd H. L., Sawyer C. H. Relationship between circulating estrogens and the central mechanisms by which ovarian steroids stimulate luteinizing hormone secretion in aged and young female rats. Endocrinology. 108:1981;836-841.
23. Miller M. A., Kolb P. E., Planas B., Raskind M. A. Estrogen receptor and neurotensin/neuromedin-N gene expression in the preoptic area are unaltered with age in Fischer 344 female rats. Endocrinology. 135:1994;1986-1995.
24. Miller M. M., Joshi D., Billiar R. B., Nelson J. F. Loss of LH-RH neurons in the rostral forebrain of old female C57BL/6J mice. Neurobiol. Aging. 11:1990;217-221.
25. Mobbs C. V., Gee D. M., Finch C. E. Reproductive senescence in female C57BL/6J mice: Ovarian impairments and neuroendocrine impairments that are partially reversible and delayable by ovariectomy. Endocrinology. 115:1984;1653-1662.
26. Mobbs C. V., Cheyney D., Sinha Y. N., Finch C. E. Age-correlated and ovary-dependent changes in relationships between plasma estradiol and luteinizing hormone, prolactin, and growth hormone in female C57BL/6J mice. Endocrinology. 116:1985;813-820.
27. Mobbs C. V. Molecular hysteresis: Residual effects of hormones and glucose on genes during aging. Neurobiol. Aging. 15:1994;523-534.
28. Rubin B. S., King J. C., Bridges R. S. Immunoreactive forms of luteinizing hormone-releasing hormone in the brains of aging rats exhibiting persistent vaginal estrus. Biol. Reprod. 31:1984;343-351.
29. Terasawa E., Wiegand S. J., Bridson W. E. A role of the medial preoptic nucleus on afternoon proestrus in female rats. Am. J. Physiol. 238:1980;E533-E539.
30. Weiland N. G., Scarbrough K., Wise P. M. Aging abolishes the estradiol-induced suppression and diurnal rhythm of proopiomelanocortin gene expression in the arcuate nucleus. Endocrinology. 131:1992;2959-2964.
31. Wise P. M. Alterations in proestrous LH, FSH, and prolactin surges in middle-aged rats. Proc. Soc. Exp. Biol. Med. 169:1982;348-354.
32. Wise P. M., McEwen B. S., Parsons B., Rainbow T. C. Age-related changes in cytoplasmic estradiol receptor concentrations in microdissected brain nuclei: Correlations with changes in steroid-induced sexual behavior. Brain Res. 321:1984;119-126.
33. Wise P. M., Parsons B. Nuclear estradiol and cytosol progestin receptor concentrations in the brain and pituitary gland and sexual behavior in ovariectomized estradiol-treated middle-aged rats. Endocrinology. 115:1984;810-816.