A humanized single-chain Fv fragment with high targeting potential against human malignant gliomas

Anticancer Research

Volumn 18, Issue 6 A, 1998, Pages 4311-4315

  Ohtomo, Toshihiko ^a   Kawata, Hiromitsu ^a   Sekimori, Yasuo ^a   Shimizu, Keiji ^b   Kishima, Haruhiko ^b   Moriuchi, Syusuke ^b   Miyao, Yasuyoshi ^b   Akamatsu, Ken Ichi ^a   Tsuchiya, Masayuki ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Anti cancer; Medulloblastoma; Ricin A chain; Single chain Fv

Indexed keywords

ANTIGEN; CANCER ANTIBODY; DRUG CARRIER; IMMUNOGLOBULIN F(AB) FRAGMENT; RICIN A; SCH M21; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANTIBODY AFFINITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG TARGETING; ESCHERICHIA COLI; GLIOBLASTOMA; GLIOMA CELL; HEPATOMA CELL; HUMAN; HUMAN CELL; INTERNALIZATION; MEDULLOBLASTOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION;

ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, NEOPLASM; BINDING SITES, ANTIBODY; CELL SURVIVAL; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOTOXINS; RECOMBINANT PROTEINS; RICIN; TUMOR CELLS, CULTURED;

EID: 0032409677     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Rorke LB, Gillies FH, Davis RL and Becker LE: Revision of the World Health Organization Classification of brain tumors for childhood brain tumors. Cancer 56: 1869-1886, 1985.
2. Dehner LP: Peripheral and central primitive neuroectodermal tumors. Archs Neurol Psychiat 110: 997-1005, 1986.
3. Hershatter, BW, Halperin EC and Cox EB: Medulloblastoma: the Duke University Medical Center Experience. Int Radiat Oncol Biol Phys 12: 1771-1777, 1986.
4. Packer RJ: Chemotherapy for medulloblastoma/primitive neuroectodermal tumors of the posterior fossa. Ann Neurol 28: 823-828, 1990.
5. Tomlinson FH, Scheithauer BW, Meyer FB, Smithson WA, Shaw EG, Miller GM and Groover RV: Medullobalstoma I. Clinical diagnostic, and therapeutic overview. J Child Neurol 7: 142-155, 1992.
6. Moriuchi, S, Shimizu K, Miyao Y and Hayakawa T: Characterization of a new mouse monoclonal antibody (ONS-M21) reactive with both medulloblastoma and gliomas. Br J Cancer 68: 831-837, 1993.
7. Ohtomo, T, Tsuchiya M, Sato K, Shimizu K, Moriuchi S, Miyao Y, Akimoto T, Akamatsu K, Hayakawa T and Ohsugi Y: Humanization of mouse ONS-M21 antibody with the aid of hybrid variable regions. Molec Immun 32: 407-416, 1995.
8. Cochler, D, Bird R, Roselli M, Hardman KD, Johnson S, Pope S, Dodd SW, Pantliano M W, Milenic DE and Schlom J: In vivo tumor targeting of a recombinant single-chain antigen-biding protein. J Natl Cancer Inst 82: 1191-1197, 1990.
9. Yokota, T, Milenic DE, Whitlow M and Schlom J: Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res 52: 3402-3408, 1992.
10. Skerra A and Plückthun A: Assembly of a functional immunoglobulin Fv fragment in Escherichia coli. Science 240: 1038-1041, 1988.
11. Tamura K, Shimizu K, Yamada M, Okamoto Y, Matsui Y, Park KC, Mabuchi E, Moriuchi S and Mogami H: Expression of major histocompatibility complex on human medulloblastoma cells with neural differentiation. Cancer Res 49: 5380-5384, 1989.
12. Lambert JM, Goldmacher VS, Collinson AR, Nadler LM and Blättler WA: An immunotoxin prepared with blocked ricin: A natural plant toxin adapted thrapeutic use. Cancer Res 57; 6236-6242, 1991.
13. Shimizu K, Park KC, Tamura K, Kishima H, Kawata H, Yoshimura Y, Sekimori Y, Miyao Y and Hayakawa T: Internalization with high targeting potential of mouse monoclonal antibody ONS-M21 recognizing human malignant glioma antigen. Cancer Letter submitted.
14. Bird, RE, Hardman KD, Jacobson JW, Johnson S, Kaufman BM, Lee S-M, Lee T, Pope SH, Riordan G and Whitlow M: Single-chain antigen-binding proteins. Science 242: 423-426, 1988.
15. Huston, JS., Levinson D, Mudgett-Hunter M, Tai M-S, Novotny J, Margolies MN, Ridge RJ, Bruccoleri RE, Harber E, Crea R and Oppermann H: Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc Natl Acad Sci USA 85: 5879-5883, 1988.
16. Francisco JA, Gilliland LK, Stebbins MR, Morris NA, Ledbetter JA and Siegall CB: Activity of a single-chain immunotoxin that selectively kills lymphoma and other B-lineage cells expressing the CD40 antigen. Cancer Res 55: 3099-3104, 1995.
17. Anand HN, Mandai S, MacKenizie CR, Sadowska J, Sigurskjold B, Young NM, Bundle DR and Narang SA: Bacterial expression and secretion of various single-chain Fv genes encoding proteins specific for a Salmonella serotype B O-antigen. J Biol Chem 266: 21874-21879, 1991.
18. Batra JK, Fitzgerald DJ, Chaudhary VK and Pastan I: Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or Diphteria toxin: Anti-TFR(Fv)-PE40 and DT388-Anti-TFR(Fv). Mol Cell Biol 11: 2200-2205, 1991.
19. Batra JK, Kasprzyk PG, Bird RE, Pastan I and Richter King C: Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin. Proc Natl Acad Sci USA 59: 5867-5871, 1992.