A novel method for detecting the analgesic effect of drugs by quantifying body movement after noxious stimulation in neonatal rat

Journal of Pharmacological and Toxicological Methods

Volumn 40, Issue 1, 1998, Pages 33-37

  Kubota, Kazufumi ^a,b   Takahashi, Tatsuhiko ^a,b   Yanagisawa, Mitsuhiko ^a,b   Fujibayashi, Kenji ^a,b   Saito, Koji ^a,b  

^a DAIICHI SANKYO CO   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Analgesia; Capsaicin; Neonatal rat; Quantification of nociceptive response

Indexed keywords

ANALGESIC AGENT; CAPSAICIN; MORPHINE; NALOXONE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BODY MOVEMENT; CONTROLLED STUDY; NEWBORN; NONHUMAN; QUANTITATIVE ASSAY; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANALGESICS; ANALGESICS, OPIOID; ANIMALS; ANIMALS, NEWBORN; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INJECTIONS, SUBCUTANEOUS; MORPHINE; MOVEMENT; NALOXONE; NARCOTIC ANTAGONISTS; NOCICEPTORS; NOISE; PAIN MEASUREMENT; PREGNANCY; RATS; RATS, WISTAR; STIMULATION, CHEMICAL;

EID: 0032409007     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(98)00033-1     Document Type: Article

References (17)

1. D'Amour FE, Smith DL (1941) A method for determining loss of pain sensation. J Pharmacol Exp Ther 72:74-79.
2. Dubuisson D, Dennis SG (1977) The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4:161-174.
3. Fanselow MS, Cramer CP (1988) The ontogeny of opiate tolerance and withdrawal in infant rats. Pharmacol Biochem Behav 31:431-438.
4. Guy ER, Abbott FV (1992) The behavioral response to formalin in preweanling rats. Pain 51:81-90.
5. Haffner F (1929) Experimentelle Prüfung schmerzstillender Mittel. Dtsch med Wschr 55:731-733.
6. Holzer P (1991) Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev 43:143-201.
7. Janesò N, Janesò-Gàbor A, Szolcsànyi J (1967) Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br J Pharmacol 31:138-151.
8. Kehoe P, Blass EM (1986) Behaviorally functional opioid systems in infant rats: II. Evidence for pharmacological, physiological, and psychological mediation of pain and stress. Behav Neurosci 100: 624-630.
9. McLaughlin CR, Dewey WL (1994) A comparison of the antinociceptive effects of opioid agonists in neonatal and adult rats in phasic and tonic nociceptive tests. Pharmacol Biochem Behav 49:1017-1023.
10. McLaughlin CR, Lichtman AH, Fanselow MS, Cramer CP (1990) Tonic nociception in neonatal rats. Pharmacol Biochem Behav 36:859-862.
11. Otsuka M, Yanagisawa M (1987) Effect of a substance P antagonist on capsaicin-induced nociceptive reflex in the isolated spinal cord-tail preparation of the rat. Acta Physiologica Hungarica 69:363-366.
12. Sakurada T, Katsumata K, Tan-No K, Sakurada S, Kisara K (1992) The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord. Neuropharmacology 31:1279-1285.
13. Spear LP, Enters EK, Aswad MA, Louzan M (1985) Drug and environmentally induced manipulations of the opiate and serotonergic systems alter nociception in neonatal rat pups. Behav Neural Biol 44:1-22.
14. Tjølsen A, Berge O-G, Hunskaar S, Rosland JH, Hole K (1992) The formalin test: an evaluation of the method. Pain 51:5-17.
15. Vander Wende C, Margolin S (1956) Analgesic tests based upon experimentally induced acute abdominal pain in rats. Fed Proc 15:494.
16. Van Praag H, Frenk H (1991) Evidence for opiate tolerance in newborn rats. Dev Brain Res 60:99-102.
17. Woolfe G, MacDonald AD (1944) The evaluation of the analgesic action of pethidine hydrochloride (Demerol). J Pharmacol Exp Ther 80:300-307.