In vivo behavior of hydrogel beads based on amidated pectins

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 5, Issue 4, 1998, Pages 239-241

  Munjeri, O ^a   Collett, J H ^a   Fell, J T ^a   Sharma, H L ^a   Smith, A M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Amidated Pectins; Beads; Hydrogel; In Vivo Behavior

Indexed keywords

AMYLOSE; CALCIUM CHLORIDE; INDOMETACIN; PECTIN; POLACRILIN; SULFAMETHOXAZOLE; TECHNETIUM 99M;

ADULT; AMIDATION; ARTICLE; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN EXPERIMENT; HYDROGEL; IN VIVO STUDY; ISOTOPE LABELING; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STOMACH EMPTYING;

EID: 0032408608     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.3109/10717549809065753     Document Type: Article

References (9)

1. Abrahamsonn, B., Alpsten, M., Jonsson, U. E., Lundberg, P. J., Sandberg, A., Sungren, M., Svenheden, A., and Tolli, J. 1996. Gastro-intestinal transit of multiple unit formulation (metoprolol CR/ZOK) and a non-disintegrating tablet with emphasis on the colon. Int. J. Pharm. 140:229-235.
2. Ashford, M., Fell, J. T., Attwood, D., Sharma, H., and Woodhead, P. 1993. An evaluation of pectin as a carrier for drug targeting to the colon. J. Control. Release. 26:213-220.
3. Ashford, M., and Fell, J. T. 1994. Targeting drugs to the colon: Delivery systems for oral administration. J. Drug Target. 2:241-258.
4. Bronsted, H., and Kopecek, J. 1990. Hydogels for site-specific oral delivery. Proc. Int. Symp. Control. Rel. Bioact. Mater. 17:128.
5. Davis, S. S., Hardy, J. G., and Fara, J. W. 1986. Transit of pharmaceutical dosage forms through the small intestine. Gut. 27:886-892.
6. Hardy, J. G., Wilson, C. G., and Wood, E. 1985. Drug delivery to the proximal colon. J. Pharm. Pharmacol. 37:1985.
7. Munjeri, O., Collett, J. H., and Fell, J. T. 1997. Amidated pectin hydrogel beads for colonic drug delivery - an in vitro study. Drug Delivery 4:207-211.
8. Rubinstein, A., Radai, R., Ezra, S., Pathak, S., and Rokem, J. S. 1993. In vitro evaluation of calcium pectinate: A potential colon-specific drug delivery carrier. Pharm. Res. 10:258-263.
9. Saffron, M., Kumar, G. S., Neckers, D. C., Pena, J., Jones, R. H., and Field, J. B. S. 1990. Biodegradable azopolymer coating for oral delivery of peptide drugs. Biochem. Soc. Trans. 18:752.