Lipid metabolism in retinal pigment epithelium (RPE): A possible role of LDL receptors;Lipidmetabolismus im retinalen pigmentepithel (RPE): Mogliche bedeutung von lipoprotein-rezeptoren

Ophthalmologe

Volumn 95, Issue 12, 1998, Pages 814-819

  Noske, Uta Maria ^a,b   Schmidt Erfurth, Ursula ^a   Meyer, Carsten ^a   Diddens, Heyke ^b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b MEDICAL LASER CENTER LÜBECK   (Germany)

Author keywords

Age related macular degeneration; LDL receptors; Metabolism of lipids; RPE cells

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR;

AGING; ARTICLE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIPID METABOLISM; PIGMENT EPITHELIUM; RECEPTOR BINDING; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA DEGENERATION;

CHOLESTEROL; HUMANS; MACULAR DEGENERATION; PIGMENT EPITHELIUM OF EYE; RECEPTORS, LDL;

EID: 0032408023     PISSN: 0941293X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003470050358     Document Type: Article

References (20)

1. Boulton M, Marshall J (1986) Effects of increasing numbers of phagocytotic inclusions on human RPE cells in culture: a modell of aging. Br J Ophthalmol 70: 808-815
2. Brown MS, Kovanen PT, Goldstein JL (1981) Regulation of plasma cholesterol by lipoprotein receptors. Science 212: 628-632
3. Delori FC (1994) Lipofuscin and drusen fluorescence in aging and age related macular degeneration. Invest Ophthalmol Vis Sci 35: S 2145
4. Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ (1989) Cell loss in the aging retina relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci 30: 1691-1699
5. Eldred GE, Lasky MR (1993) Retinal age pigments generated by self-assembling lysomotropic detergents. Nature 361: 724-726
6. Feeney-Burns L et al. (1980) Lipofuscin of the human retinal pigment epithelium. Am J Ophthalmol 90: 783-791
7. Gass JD (1973) Drusen and disciform macular detachment and degeneration. Arch Ophthalmol 90: 206-217
8. Goldstein JL, Anderson RGW, Brown MS (1979) Coated pits, coated vesicles and receptor-mediated endocytosis. Nature 297: 679-684
9. Goldstein JL, Ho YK, Basu SK, Brown MS (1979) Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein producing massive cholesterol deposition. J Cell Biol 76: 333-338
10. Havel R, Eder HA, Bragdon JH (1955) Distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34: 1345-1353
11. Hayes KC, Lindsey S, Stephan ZF, Brecker D (1989) Retinal pigment epithelium posesses both LDL and scavenger activity. Invest Ophthalmol Vis Sci 30: 225-232
12. Kovanen PT, Basu SK, Goldstein JL, Brown MS (1979) Low density lipoprotein receptor in bovine adrenal cortex. Endocrinology 104: 610-616
13. Lougheed M, Steinbrecher U (1996) Mechanism of uptake of copper-oxidized low density lipoprotein in macrophages is dependent on its extent of oxidation. J Biol Chem 271: 11798-11805
14. Mahley RW, Innerarity TL (1979) Lipoprotein receptors and cholesterol homeostasis. Biochim Biophys Acta 737: 197-205
15. Pauleikhoff D, Harper A, Marshall J, Bird AC (1990) Aging changes in Bruchs membrane. A histochemical and morphological study. Ophthalmology 97: 171-178
16. Rudling JM, Reihner E, Einarsson K, Ewerth S, Angelin B (1990) Low density lipoprotein receptor binding activity in human tissues. Proc Natl Acad Sci USA 87: 3469-3473
17. Storch J, Kleinfeld AM (1982) The lipid structure of biological membranes. Trends Biochem Sci 10: 418-421
18. Teupser D, Thiery J, Walli AK, Seidel D (1996) Determination of LDL- and scavenger-receptor activity in adherent and non-adherent cultured cells with a new single-step fluorometric assay. Acta Biochim Biophys 1303: 193-198
19. Vingerling JR, Dielemans I, Bots ML, Grobbee DE, Hofman A, de Jong PTVM (1995) Age-related macular degeneration is associated with atherosclerosis. The Rotterdam Study. Am J Epidemiol 142: 404-409
20. Young RW (1987) Pathophysiology of age related macular degeneration. Surv Ophthalmol 31: 292-306