Molecular Diagnosis and Characterization of Hb Zürich [β63(E7)His→Arg] Carriers in a Kentucky Family

Hemoglobin

Volumn 22, Issue 42130, 1998, Pages 509-515

  Aguinaga, M D P ^a,b   Wright, C J ^a,c   Roa, P D ^a,b   Terrell, F ^a   Turner, E A ^a,b   Houston, M ^a,c  

^a Division of Hematology/Oncology   (United States)

^b MEHARRY MEDICAL COLLEGE   (United States)

^c WESTERN KENTUCKY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; HEMOGLOBIN VARIANT; PHENAZOPYRIDINE; SULFONAMIDE;

ADULT; ANEMIA; ANTIBIOTIC THERAPY; CHILD; CLINICAL ARTICLE; CONFERENCE PAPER; DNA SEQUENCE; DRUG INDUCED DISEASE; FEMALE; HEMATOLOGICAL PARAMETERS; HEMOLYTIC ANEMIA; HUMAN; MALE; PEDIGREE ANALYSIS; POLYMERASE CHAIN REACTION; URINARY TRACT INFECTION;

ANEMIA, HEMOLYTIC; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; ERYTHROCYTE COUNT; FEMALE; HEMOGLOBINOPATHIES; HEMOGLOBINS, ABNORMAL; HETEROZYGOTE; HUMANS; KENTUCKY; MALE; MUTATION; PEDIGREE;

EID: 0032406758     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.3109/03630269809071548     Document Type: Article

References (7)

1. Hitzig W. H., Frick P. G., Betke K., Huisman T. H.J. Hämoglobin Zurich: eine neue hämoglobinanomalie mit sulfonamindinduzierter innenkörperanämie. Helvt. Paediatr. Acta. 1960; 15: 499 – 514
2. Roa D., Turner E. A., Aguinaga M.D.P. Effect of the environment on the detection of hemoglobin variants from dried blood filter paper specimens by HPLC. Ann. Clin. Lab. Sci. 1993; 23: 433 – 438
3. Bardhan S., Sharan C., Singh D. N., Turner E. A., Aguinaga M. d.P. A simplified procedure for isolation of highly purified genomic DNA. Bionature 1992; 12: 89 – 94
4. Aguinaga M. d.P., Wright C. J., Roa P. D., Terrell F., Turner E. A., Liu Y., Houston M. Molecular characterization of Hb Zürich (β63 His→Arg) identifies a CAT→CGT change at the DNA sequence. 18th Meeting of the National Sickle Cell Disease Program, Philadelphia, PA, 1993, Abstract 110a
5. Dickerman J. D., Holtzman N. A., Zinkham W. H. Hb Zürich: a third family presenting with hemolytic reactions to sulfonamides. Am. J. Med. 1973; 55: 638 – 642
6. Huisman T. H.J., Carver M. F.H., Efremov G. D. A Syllabus of Human Hemoglobin Variants, second edition. The Sickle Cell Anemia Foundation, Augusta, GA, USA 1998
7. Virshup D. M., Zinkham W. H., Sirota R. L., Caughey W. S. Unique sensitivity of Hb Zürich to oxidative injury by phenazopyridine: reversal of the effects by elevating carboxyhemoglobin levels in vivo and in vitro. Am. J. Hematol. 1983; 14: 315 – 324