Efficacy of the fixed 1.2% clindamycin phosphate, 0.025% tretinoin gel formulation (Velac®) and a proprietary 0.025% tretinoin gel formulation (Aberela®) in the topical control of facial acne

Journal of the European Academy of Dermatology and Venereology

Volumn 11, Issue 3, 1998, Pages 227-233

  Richter, J R ^a   Forstrom L R ^b   Kiistala, U O ^c   Jung, E G ^d  

^a ASTELLAS PHARMA INC   (Japan)

^b Keskuskadun Laakarikeskus   (Finland)

^c CENTRAL MILITARY HOSPITAL   (Finland)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Aberela ; Acne vulgaris; Clindamycin; Clinical trials; Cutaneous administration; Double blind method; Drug combinations; Tretinoin; Velac gel

Indexed keywords

ABERELA; CLINDAMYCIN; CLINDAMYCIN PLUS RETINOIC ACID; RETINOIC ACID; UNCLASSIFIED DRUG;

ACNE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ACNE VULGARIS; ADOLESCENT; ADULT; CLINDAMYCIN; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FACIAL DERMATOSES; FEMALE; GELS; HUMANS; MALE; TREATMENT OUTCOME; TRETINOIN;

EID: 0032406192     PISSN: 09269959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0926-9959(98)00071-3     Document Type: Article

References (10)

1. Mills OH, Kligman AM. Treatment of acne vulgaris with topically applied erythromycin and tretinoin. Acta Derm Venereol (Stockh) 1978;58:555-557.
2. Rietschel RL, Duncan SH. Clindamycin phosphate used in combination with tretinoin in the treatment of acne. Int J Dermatol 1983;22:41-43.
3. Aron-Brunetiere R, Hewitt J, Puisant A, et al. Etude comparative a double insu de deux traitements locaux de l'acne: la tretinoine et l'association tretinoine erythromycine base. Gaz Med France 1980;87:3635-3638.
4. Amblard P, Bazex A, Beylot C, et al. L'association tretinoine-erythromycine base. Nouveau traitement local de l'acne. Etude multicentrique sur 347 cas. Sem Hop Paris 1980;56:911-915.
5. Korting HC, Braun-Falco O. Efficacy and tolerability of combined topical treatment of acne vulgaris with tretinoin and erythromycin in general practice. Drugs Exp Clin Res 1989;15(9):447-451.
6. Kossmann J. Simultaneous local treatment of acne vulgaris with tretinoin and erythromycin: results of an open multicentre trial. Aktuelle Dermatologie 1989;15:258-260.
7. Pfannschmidt N, Bauer R, Kreysel HW. Combined treatment of acne vulgaris with topical erythromycin and tretinoin. Z Hautkr 1988;63:366-368.
8. Fonseca E, Ferrandiz C, Camarasa JG, et al. Erythromycin lauryl sulphate in combination with tretinoin in the topical treatment of acne vulgaris. A multi-centre, double-blind clinical trial. J Dermatol Treat 1995;6:47-50.
9. Richter JR, Bonsema MT, De Boulle KLVM, et al. Efficacy of a fixed clindamycin phosphate 1.2% tretinoin 0.025% gel formulation (Velac) in the topical control of facial acne lesions. J Dermatol Treat 1998;9:81-90.
10. Allen BS, Graham Smith J. Various parameters for grading acne vulgaris. Arch Dermatol 1982;11:23-25.