A new synthesis of [3-11C]pyruvic acid using alanine racemase

Applied Radiation and Isotopes

Volumn 49, Issue 12, 1998, Pages 1557-1562

  Ikemoto, M ^a,b   Sasaki, M ^a,c   Haradahira, T ^a   Okamoto, E ^b   Omura, H ^b,d   Furuya, Y ^b,d   Watanabe, Y ^d,e   Suzuki, K ^a,d  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b Ikeda Tohka Industries Co Ltd   (Japan)

^c SUMITOMO HEAVY INDUSTRIES LTD   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME IMMOBILIZATION; ENZYMES; ORGANIC ACIDS; POSITRON EMISSION TOMOGRAPHY;

ALANINE RACEMASE; PYRUVIC ACID;

SYNTHESIS (CHEMICAL);

ALANINE; ALANINE DEHYDROGENASE; ALANINE RACEMASE; CARBON 11; CATALASE; DEXTRO AMINO ACID OXIDASE; PYRUVIC ACID;

ARTICLE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME IMMOBILIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 0032404361     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(98)00052-9     Document Type: Article

References (17)

1. Allain, C. C., Poon, L. S., Chan, C. S., Richmond, W. and Fu, P. C. (1974) Enzymatic determination of total serum cholesterol. Clin. Chem. 20, 470.
2. 11C]phenylalanine. J. Labelled Compd. Radiopharm. 24, 125.
3. Bergström, M., Eriksson, B., Öberg, K., Sundin, A., Ahlström, H., Lindner, K. J., Bjurling, P. and Långström, B. (1996) In vivo demonstration of enzyme activity in endocrine pancreatic tumors: Decarboxylation of carbon-11-DOPA to carbon-11-dopamine. J. Nucl. Med. 37, 32.
4. 11C]pyruvic acid, a useful synthon, via an enzymatic route. Appl. Radiat. Isot. 39, 627.
5. 11C-labelled L-tyrosine and L-DOPA. Acta Chem. Scand. 44, 183.
6. 13N-labeled L-amino acids. Anal. Biochem. 111, 42.
7. Galakatos, N. G. and Walsh, C. T. (1987) Specific proteolysis of native alanine racemase from Salmonella typhimurium: Identification of the cleavage site and characterization of the clipped two-domain proteins. Biochemistry 26, 8475.
8. Hartvig, P., Lindner, K. J., Bjurling, P., Långström, B. and Tedroff, J. (1995) Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography. J. Neural Transm. 102, 91.
9. Heiss, W. D., Wienhard, K., Wagner, R., Lanfermann, H., Thiel, A., Herholz, K. and Pietrzyk, U. (1996) F-Dopa as an amino acid tracer to detect brain tumors. J. Nucl. Med. 37, 1180.
10. Inagaki, K., Tanizawa, K., Badet, B., Walsh, C. T., Tanaka, H. and Soda, K. (1986) Thermostable alanine racemase from Bacillus stearothermophilus: Molecular cloning of the gene, enzyme purification, and characterization. Biochemistry 25, 3268.
11. Ohshima, T. and Soda, K. (1979) Purification and properties of alanine dehydrogenase from Bacillus sphaericus. Eur. J. Biochem. 100, 29.
12. Sakamoto, Y., Nagata, S., Esaki, N., Tanaka, H. and Soda, K. (1990) Gene cloning, purification, and characterization of thermostable alanine dehydrogenase of Bacillus stearothermophilus. J. Ferment. Bioeng. 69, 154.
13. Saier, M. H. and Jenkins, W. T. (1967) Alanine amino-transferase. I. Purification and properties. J. Biol. Chem. 242, 91.
14. Soda, K., Tanaka, H. and Tanizawa, K. (1988) Thermostable alanine racemase and its application to D-amino acid synthesis. Ann. N. Y. Acad. Sci. 542, 375.
15. 13N]glutamate ready for intravenous injection. Int. J. Appl. Radiat. Isot. 35, 771.
16. 11C]methylspiperone with high specific activity and high radiochemical purity for PET studies: Suppression of its radiolysis. Appl. Radiat. Isot. 41, 593.
17. 11C]-tyrosine and PET. J. Nucl. Med. 36, 411.