A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription

Cancer Research

Volumn 58, Issue 23, 1998, Pages 5321-5325

  Rutter, Joni L ^a   Mitchell, Teresa I ^a   Butticè, Giovanna ^b   Meyers, Jennifer ^a   Gusella, James F ^c   Ozelius, Laurie J ^c   Brinckerhoff, Constance E ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b INSTITUT DE BIOLOGIE DE LILLE   (France)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CANCER GROWTH; CELL INVASION; DNA SEQUENCE; EXTRACELLULAR MATRIX; FIBROBLAST; GENE FREQUENCY; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; MELANOMA CELL; METASTASIS; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

BINDING SITES; COLLAGENASES; CONSENSUS SEQUENCE; DNA; DNA, NEOPLASM; FIBROBLASTS; GUANINE; HUMANS; MATRIX METALLOPROTEINASE 1; MELANOMA; NUCLEOTIDES; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; PROTO-ONCOGENE PROTEINS C-JUN; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0032404174     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Borden, P., and Heller, R. Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases. Crit. Rev. Eukaryotic Gene Expr., 7: 159-178, 1997.
2. Vincenti, M. P., White, L. A., Schroen, D. J., Benbow, U., and Brinckerhoff, C. E. Regulating expression of the gene for matrix metalloproteinase-1 (Collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability. Crit. Rev. Eukaryotic Gene Expr., 6: 391-411, 1996.
3. Chambers, A. F., and Matrisian, L. M. Changing views of the role of matrix metalloproteinases in metastasis. J. Natl. Cancer Inst., 89: 1260-1270, 1997.
4. Murray, G. I., Duncan, M. E., O'Neil, P., Melvin, W. T., and Fothergill, J. E. Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Nat. Med., 2: 461-462, 1996.
5. Murray, G. I., Duncan, M. E., O'Neil, P., McKay, J. A., Melvin, W. T., and Fothergill, J. E. Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. J. Pathol., 185: 256-261, 1998.
6. Butticè, G., Duterque-Coquillaud, M., Basuyaux, J. P., Carrere, S., Kurkinen, M., and Stehelin, D. Erg, an Ets-family member, differentially regulates human collagenase-1 (MMP-1) and stromelysin-1 (MMP-3) gene expression by physically interacting with the Fos/Jun complex. Oncogene 13: 2297-2306, 1996.
7. Basuyaux, J. P., Ferreira, E., Stehelin, D., and Butticè, G. The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner. J. Biol. Chem., 272: 26188-26195, 1997.
8. Gutman, A., and Wasylyk, B. The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites. EMBO J., 9: 2241-2246, 1990.
9. Benbow, U., and Brinckerhoff, C. E. The AP-1 site and MMP gene regulation: what is all the fuss about? Matrix Biol., 15: 519-526, 1997.
10. Rutter, J. L., Benbow, U., Coon, C. I., and Brinckerhoff, C. E. Cell-type specific regulation of human interstitial collagenase-1 gene expression by interleukin-1β (IL-1β) in human fibroblasts and BC-8701 breast cancer cells. J. Cell. Biochem., 66: 322-336, 1997.
11. Aho, S., Rouda, S., Kennedy, S. H., Qin, H., and Tan, E. M. L. Regulation of human interstitial collagenase (matrix metalloproteinase-1) promoter activity by fibroblast growth factor. Eur. J. Biochem., 247: 503-510, 1997.
12. Delany, A. M., and Brinckerhoff, C. E. Post-transcriptional regulation of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibroblasts. J. Cell. Biochem., 50: 400-410, 1992.
13. Templeton, N., Brown, P. D., Levy, A. T., Margulies, I. M., Liotta, L. A., and Stetler-Stevenson, W. G. Cloning and characterization of human tumor cell interstitial collagenase. Cancer Res., 50: 5431-5437, 1990.
14. Imai, S-I., Fujino, T., Nishibayashi, S., Manabe, T., and Takano, T. Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type 1 collagenase gene in SV40 large T antigen-transformed immortal human fibroblasts. Mol. Cell. Biol., 14: 7182-7194, 1994.
15. Graves, B. J. Inner workings of a transcription factor partnership. Science (Washington DC), 279: 1000-1001, 1998.
16. Pan, L., Chamberlain, S. H., Auble, D. T., and Brinckerhoff, C. E. Differential regulation of collagenase gene expression by retinoic acid receptors-α, β and γ. Nucleic Acids Res., 20: 3105-3111, 1992.
17. Hirt, B. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol., 26: 365-369, 1967.
18. Schroen, D. J., and Brinckerhoff, C. E. Inhibition of rabbit collagenase (matrix metalloproteinase-1; MMP-1) transcription by retinoid receptors: evidence for binding of RARs/RXRs to the -77 AP-1 site through interactions with c-Jun. J. Cell. Physiol., 169: 320-332, 1996.
19. Wasylyk, B., Hahn, S. L., and Giovane, A. The Ets family of transcription factors. Eur. J. Biochem., 211: 7-18, 1993.
20. White, L. A., Maute, C., and Brinckerhoff, C. E. ETS sites in the promoters of the matrix metalloproteinases collagenase (MMP-1) stromelysin (MMP-3) are auxiliary elements that regulate basal and phorbol-induced transcription. Connect. Tissue Res., 36: 321-335, 1997.
21. Vincenti, M. P., Coon, C. I., and Brinckerhoff, C. E. NFkB/p50 activates an element in the distal matrix metalloproteinase-1 promoter in interleukin-1β-stimulated synovial fibroblasts. Arthritis Rheum., in press, 1998.
22. Bassuk, A. G., and Leiden, J. A direct physical association between ETS and AP-1 transcription factors in normal human T cells. Immunity, 3: 223-237, 1995.
23. Wang, D. G., Fan, J-B., Siao, C-J., Berno, A., Lander, E. S., et al. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science (Washington DC), 280: 1077-1082, 1998.