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1
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0031303551
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Indoor allergens and asthma
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of special interest. This provides a full review of the recent results on indoor allergens: immunochemistry, molecular biology and immune responses. The report also includes evaluation of the epidemiology of asthma and the relevance of allergen avoidance to the treatment of allergic disease.
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Platts-Mills TAE, Vervloet D, Thomas WR, Aalberse RC, Chapman MD. Indoor allergens and asthma. of special interest J Allerg Clin Immunol. 100:1997;S1-S24 This provides a full review of the recent results on indoor allergens: immunochemistry, molecular biology and immune responses. The report also includes evaluation of the epidemiology of asthma and the relevance of allergen avoidance to the treatment of allergic disease.
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(1997)
J Allerg Clin Immunol
, vol.100
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-
Platts-Mills, T.A.E.1
Vervloet, D.2
Thomas, W.R.3
Aalberse, R.C.4
Chapman, M.D.5
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2
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0030760310
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Induction of IgE antibody responses by glutathione S-transferase from the German cockroach [Blattella germanica]
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Arruda LK, Vailes LD, Platts-Mills TAE, Hayden ML, Chapman MD. Induction of IgE antibody responses by glutathione S-transferase from the German cockroach [Blattella germanica]. J Biol Chem. 272:1997;20907-20912.
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(1997)
J Biol Chem
, vol.272
, pp. 20907-20912
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-
Arruda, L.K.1
Vailes, L.D.2
Platts-Mills, T.A.E.3
Hayden, M.L.4
Chapman, M.D.5
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3
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0031841770
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Cloning of the American cockroach Cr-PII allergens: Evidence for the existence of cross-reactive allergens between species
-
of special interest. The authors describe the definition of Per a 1 and the homologous Bla g 1 allergens from the German cockroach; they have also identified a novel structure with repeated amino-acid motifs. The relevance of this structure is not clear but it could possibly allow cross-linking of IgE molecules; however, this is the only allergen shown to have a structure of this kind.
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Wu CH, Wang NM, Lee MF, Kao CYY, Luo SF. Cloning of the American cockroach Cr-PII allergens: evidence for the existence of cross-reactive allergens between species. of special interest J Allerg Clin Immunol. 101:1998;832-840 The authors describe the definition of Per a 1 and the homologous Bla g 1 allergens from the German cockroach; they have also identified a novel structure with repeated amino-acid motifs. The relevance of this structure is not clear but it could possibly allow cross-linking of IgE molecules; however, this is the only allergen shown to have a structure of this kind.
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(1998)
J Allerg Clin Immunol
, vol.101
, pp. 832-840
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Wu, C.H.1
Wang, N.M.2
Lee, M.F.3
Kao, C.Y.Y.4
Luo, S.F.5
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4
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0032515169
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Novel allergen structures with tandem amino acid repeats derived from German and American cockroach
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in press
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Pomes A, Melen E, Vailes LD, Retief JD, Arruda LK, Chapman MD. Novel allergen structures with tandem amino acid repeats derived from German and American cockroach. J Biol Chem. 1998;. in press.
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(1998)
J Biol Chem
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-
Pomes, A.1
Melen, E.2
Vailes, L.D.3
Retief, J.D.4
Arruda, L.K.5
Chapman, M.D.6
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6
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0032491584
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Definition of serine proteinases derived from Trichophyton that induce IgE antibody and cell mediated immune response in humans
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Woodfolk JA, Wheatley LM, Piyasena RV, Benjamin DC, Platts-Mills TAE. Definition of serine proteinases derived from Trichophyton that induce IgE antibody and cell mediated immune response in humans. J Biol Chem. 273:1998;29489-29496.
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(1998)
J Biol Chem
, vol.273
, pp. 29489-29496
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Woodfolk, J.A.1
Wheatley, L.M.2
Piyasena, R.V.3
Benjamin, D.C.4
Platts-Mills, T.A.E.5
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7
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0028818335
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A major house dust mite allergen disrupts the IgE network by selectively cleaving CD23
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Hewitt CRA, Brown AP, Hart BD, Pritchard DI. A major house dust mite allergen disrupts the IgE network by selectively cleaving CD23. J Exp Med. 182:1995;1537-1544.
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(1995)
J Exp Med
, vol.182
, pp. 1537-1544
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Hewitt, C.R.A.1
Brown, A.P.2
Hart, B.D.3
Pritchard, D.I.4
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8
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0031975246
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Proteolytic cleavage of CD-25 by Der p 1, a major mite allergen with cysteine protease activity
-
of outstanding interest. This report demonstrates unequivocally that Der p 1 can cleave CD25 in vitro, thus inactivating the IL-2 receptor; furthermore, the authors establish that inactivating the receptor can inhibit the in vitro response of human T cells to IL-2; however, the mite protein has to be treated with a reducing agent, such as cysteine, in order to be active. In a recent Immunology Today article, Shakib and co-workers argue strongly that this enzymatic activity is likely to enhance allergenicity.
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Schulz O, Sewell HF, Shakib F. Proteolytic cleavage of CD-25 by Der p 1, a major mite allergen with cysteine protease activity. of outstanding interest J Exp Med. 187:1998;271-275 This report demonstrates unequivocally that Der p 1 can cleave CD25 in vitro, thus inactivating the IL-2 receptor; furthermore, the authors establish that inactivating the receptor can inhibit the in vitro response of human T cells to IL-2; however, the mite protein has to be treated with a reducing agent, such as cysteine, in order to be active. In a recent Immunology Today article, Shakib and co-workers argue strongly that this enzymatic activity is likely to enhance allergenicity.
-
(1998)
J Exp Med
, vol.187
, pp. 271-275
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Schulz, O.1
Sewell, H.F.2
Shakib, F.3
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9
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0032032239
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The house dust mite allergen, Dermatophagoides pteronyssinus, promotes type 2 responses by modulating the balance between IL-4 and IFN-gamma
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of special interest. This is a clear demonstration that the enzymic activity of the allergen Der p 1 can influence the immune response to another protein in mice. Using two different regimes they show that Der p 1, but not heat-inactivated Der p 1, can inhibit IFN-γ production. The authors suggest that exposure to this allergen in vivo could influence the human immune response to other allergens.
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Comoy EE, Pestel J, Duez C, Stewart G, Vendeville C, Fournier C, Finkelman F, Capron A, Thyphronitis G. The house dust mite allergen, Dermatophagoides pteronyssinus, promotes type 2 responses by modulating the balance between IL-4 and IFN-gamma. of special interest J Immunol. 160:1998;2456-2462 This is a clear demonstration that the enzymic activity of the allergen Der p 1 can influence the immune response to another protein in mice. Using two different regimes they show that Der p 1, but not heat-inactivated Der p 1, can inhibit IFN-γ production. The authors suggest that exposure to this allergen in vivo could influence the human immune response to other allergens.
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(1998)
J Immunol
, vol.160
, pp. 2456-2462
-
-
Comoy, E.E.1
Pestel, J.2
Duez, C.3
Stewart, G.4
Vendeville, C.5
Fournier, C.6
Finkelman, F.7
Capron, A.8
Thyphronitis, G.9
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10
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0019433010
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Mite faeces are the major source of house dust allergens
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Tovey ER, Chapman MD, Platts-Mills TAE. Mite faeces are the major source of house dust allergens. Nature. 289:1981;592-593.
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(1981)
Nature
, vol.289
, pp. 592-593
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Tovey, E.R.1
Chapman, M.D.2
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11
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0031157105
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Of mites and men: Trypsin-like proteases in the lungs
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Caughey GH. Of mites and men: trypsin-like proteases in the lungs. Am J Respir Cell Molec Biol. 16:1977;621-628.
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Caughey, G.H.1
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12
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0029562654
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Cloning of cockroach allergen, Bla g 4, identified ligand binding proteins (or calycins) as a cause of IgE antibody responses
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Arruda LK, Vailes LD, Hayden ML, Benjamin DC, Chapman MD. Cloning of cockroach allergen, Bla g 4, identified ligand binding proteins (or calycins) as a cause of IgE antibody responses. J Biol Chem. 270:1995;31196-31201.
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, pp. 31196-31201
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Arruda, L.K.1
Vailes, L.D.2
Hayden, M.L.3
Benjamin, D.C.4
Chapman, M.D.5
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13
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0031921016
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Recombinant allergens for immunotherapy: A Der p 2 variant with reduced IgE reactivity retains T cell epitopes
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Smith AM, Chapman MD, Taketomi EA, Platts-Mills TAE, Sung SSJ. Recombinant allergens for immunotherapy: a Der p 2 variant with reduced IgE reactivity retains T cell epitopes. J Allerg Clin Immunol. 101:1998;423-425.
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J Allerg Clin Immunol
, vol.101
, pp. 423-425
-
-
Smith, A.M.1
Chapman, M.D.2
Taketomi, E.A.3
Platts-Mills, T.A.E.4
Sung, S.S.J.5
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14
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0030471602
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X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy
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Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, van Neerven RJJ, Schou C, Lowenstein H, Spangfort MD. X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nature Struct Biology. 3:1996;1040-1045.
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Nature Struct Biology
, vol.3
, pp. 1040-1045
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Gajhede, M.1
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Poulsen, F.M.3
Ipsen, H.4
Larsen, J.N.5
Van Neerven, R.J.J.6
Schou, C.7
Lowenstein, H.8
Spangfort, M.D.9
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15
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0031982705
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Solution structure of Der f 2, the major mite allergen for atopic diseases
-
15N. The analysis was performed at 55°C in the detergent in N-octyl-beta-D glucosidase at 140 nM. We believe that these conditions are largely responsive for the apparent differences in tertiary structure between Der f 2 and the Der p 2 structure reported in [16].
-
15N. The analysis was performed at 55°C in the detergent in N-octyl-beta-D glucosidase at 140 nM. We believe that these conditions are largely responsive for the apparent differences in tertiary structure between Der f 2 and the Der p 2 structure reported in [16].
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(1998)
J Biol Chem
, vol.273
, pp. 356-360
-
-
Ichikawa, S.1
Hatanaka, H.2
Yuuki, T.3
Iwamoto, N.4
Kojima, S.5
Nishiyama, C.6
Ogura, K.7
Okumura, Y.8
Inagaki, F.9
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16
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85030342609
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Solution structure of the mite allergen Der p 2 by nuclear magnetic resonance
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of special interest, sheets is different. The binding sites of monoclonal antibodies were analyzed both by protection assays and by using multiple substitutions of predicted surface amino acids with alanine. NMR analyses of proteins are limited both by the size of the molecule (generally it must be less than 18,000 daltons) and by the cost of labelling proteins with the heavy isotopes necessary for specific forms of resonance
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Mueller GA, Benjamin DC, Rule G. Solution structure of the mite allergen Der p 2 by nuclear magnetic resonance. of special interest Biochemistry. 1998; This describes the solution structure of Der p 2 expressed in Escherichia Coli; the authors used heavy isotopes but with analysis under less stringent conditions than those used by Ichikawa et al. [15] to analyze Der f 2. The structure is basically the same but the angle between the two layers of β-sheets is different. The binding sites of monoclonal antibodies were analyzed both by protection assays and by using multiple substitutions of predicted surface amino acids with alanine. NMR analyses of proteins are limited both by the size of the molecule (generally it must be less than 18,000 daltons) and by the cost of labelling proteins with the heavy isotopes necessary for specific forms of resonance.
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(1998)
Biochemistry
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Mueller, G.A.1
Benjamin, D.C.2
Rule, G.3
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17
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0031134213
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Evaluation of German cockroach (Orthoptera: Blattellidae) allergen and it's seasonal variation in low-income housing
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Mollet J, Vailes LD, Avner DB, Perzanowski MS, Arruda LK, Chapman MD, Platts-Mills TAE. Evaluation of German cockroach (Orthoptera: Blattellidae) allergen and it's seasonal variation in low-income housing. J Med Entomol. 34:1997;307-311.
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J Med Entomol
, vol.34
, pp. 307-311
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Mollet, J.1
Vailes, L.D.2
Avner, D.B.3
Perzanowski, M.S.4
Arruda, L.K.5
Chapman, M.D.6
Platts-Mills, T.A.E.7
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18
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0031017771
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Dust and airborne exposure to allergen derived from cockroach (Blattella germanica) in low cost public housing of Strasbourg France
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De Blay F, Sanchez J, Hedelin G, Perez-Infante A, Verot A, Chapman MD, Pauli G. Dust and airborne exposure to allergen derived from cockroach (Blattella germanica) in low cost public housing of Strasbourg France. J Allerg Clin Immunol. 99:1997;107-112.
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J Allerg Clin Immunol
, vol.99
, pp. 107-112
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De Blay, F.1
Sanchez, J.2
Hedelin, G.3
Perez-Infante, A.4
Verot, A.5
Chapman, M.D.6
Pauli, G.7
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19
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Atopy and the ectopic immune response
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Aalberse RC. Atopy and the ectopic immune response. Immunol Cell Biol. 74:1996;201-205.
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Immunol Cell Biol
, vol.74
, pp. 201-205
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Aalberse, R.C.1
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20
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0026500449
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The IgG antibody subclass response to an inhalant allergen (Dermatophagoides pteronyssinus) during the first year of life: Evidence for the early stimulation of the immune system following natural exposure
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Mariani F, Price JF, Kemeny DM. The IgG antibody subclass response to an inhalant allergen (Dermatophagoides pteronyssinus) during the first year of life: evidence for the early stimulation of the immune system following natural exposure. Clin Experiment Allergy. 22:1992;29-33.
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Mariani, F.1
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Kemeny, D.M.3
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21
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0030831525
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Atopic versus infectious diseases in childhood: A question of balance
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of special interest. Here, the authors present the argument that changes in immune responsiveness early in childhood or in utero could have shifted the balance from Th1 to Th2 responses. The model includes a major role for early childhood viral infections and the normal gut flora in polarizing the immune response. The argument is that in the absence of a strong Th1 stimulus in early childhood, T cells will be primed as Th2 memory cells that could play a role in allergic disease later in life.
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Holt PG, Sly PD, Bjorksten B. Atopic versus infectious diseases in childhood: a question of balance. of special interest Pediat Allergy Immunol. 8:1997;53-58 Here, the authors present the argument that changes in immune responsiveness early in childhood or in utero could have shifted the balance from Th1 to Th2 responses. The model includes a major role for early childhood viral infections and the normal gut flora in polarizing the immune response. The argument is that in the absence of a strong Th1 stimulus in early childhood, T cells will be primed as Th2 memory cells that could play a role in allergic disease later in life.
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(1997)
Pediat Allergy Immunol
, vol.8
, pp. 53-58
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Holt, P.G.1
Sly, P.D.2
Bjorksten, B.3
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22
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0029790675
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Periferal blood mononuclear cell proliferative responses in the first year of life in babies born to allergic parents
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Miles EA, Warner JA, Jones AC, Colwell BM, Bryant TM, Warner JO. Periferal blood mononuclear cell proliferative responses in the first year of life in babies born to allergic parents. Clin Experiment Allergy. 26:1996;780-788.
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Clin Experiment Allergy
, vol.26
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Miles, E.A.1
Warner, J.A.2
Jones, A.C.3
Colwell, B.M.4
Bryant, T.M.5
Warner, J.O.6
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23
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0029112640
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Allergen-specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: Covert responses are unmasked by serum-free medium
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Upham JW, Holt BJ, Baron-Hay MJ, Yabuhara A, Hales BJ, Thomas WR, Loh RKS, O'Keefe PT, Palmer L, Le Souef PN, et al. Allergen-specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum-free medium. Clin Experiment Allergy. 25:1995;634-642.
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Upham, J.W.1
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Baron-Hay, M.J.3
Yabuhara, A.4
Hales, B.J.5
Thomas, W.R.6
Loh, R.K.S.7
O'Keefe, P.T.8
Palmer, L.9
Le Souef, P.N.10
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24
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0030769899
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Human T cell responses to Trichophyton tonsurans: Inhibition using the serum free medium Aim V
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Slunt JB, Taketomi EA, Platts-Mills TAE. Human T cell responses to Trichophyton tonsurans: inhibition using the serum free medium Aim V. Clin Experiment Allergy. 27:1997;1184-1192.
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Clin Experiment Allergy
, vol.27
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Slunt, J.B.1
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25
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0029832528
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Low level exposure to house dust mites stimulates T cell responses during early childhood independent of atopy
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Bjorksten B, Holt BJ, Baron-Kay MJ, Munir AKM, Holt PG. Low level exposure to house dust mites stimulates T cell responses during early childhood independent of atopy. Clin Experiment Allergy. 26:1996;775-779.
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Bjorksten, B.1
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Baron-Kay, M.J.3
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Holt, P.G.5
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26
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Parental history of asthma and allergies as predictors of asthma: Does mother confer more than father?
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Litonjua A, Carey VJ, Burge HA, Weiss ST, Gold DR. Parental history of asthma and allergies as predictors of asthma: does mother confer more than father? Am J Respir Crit Care Med. 158:1998;176-181.
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Litonjua, A.1
Carey, V.J.2
Burge, H.A.3
Weiss, S.T.4
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27
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Chimeric monoclonal antibodies to the mite allergen Der p 2
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Amsterdam: University of Amsterdam
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Schuurman J, Aalberse RC. Chimeric monoclonal antibodies to the mite allergen Der p 2. PhD Thesis. 1997;University of Amsterdam, Amsterdam.
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Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice
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Takeda K, Hamelmann E, Joetham A, Shultz LD, Larsen GL, Irvin CG, Gelfand EW. Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J Exp Med. 186:1997;449-454.
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Takeda, K.1
Hamelmann, E.2
Joetham, A.3
Shultz, L.D.4
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Holgate ST, Chadwick D. The Rising Trends in Asthma. 1997;J Wiley & Sons, Chichester.
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The Rising Trends in Asthma
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31
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20-year trends in the prevalence of asthma and chronic airflow obstruction in an HMO
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Vollmer WM, Osborne ML, Buist AS. 20-year trends in the prevalence of asthma and chronic airflow obstruction in an HMO. Am J Respir Crit Care Med. 157:1998;1079-1084.
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, pp. 1079-1084
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Vollmer, W.M.1
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Nakagomi J, Itaya H, Tominaga T, Yamaki H, Hisamaisu S, Nakagomi O. Is atopy increasing? Lancet. 343:1994;121-122.
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Von Mutius E, Martinez FD, Fritzsch C, Nicolai T, Roell C, Thiemann HH. Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respir Crit Care Med. 149:1994;358-364.
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Von Mutius, E.1
Martinez, F.D.2
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34
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Investigation into the increase in hay fever and eczema at age 16 observed between the 1958 and 1970 British birth cohorts
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Butland BK, Strachan DP, Lewis S, Brynner J, Butler N, Britton J. Investigation into the increase in hay fever and eczema at age 16 observed between the 1958 and 1970 British birth cohorts. Brit Med J. 315:1997;717-721.
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Butland, B.K.1
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35
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0030769394
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Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia
-
of special interest. This provides a comparison of respiratory symptoms and skin tests to common allergens in two populations in Ethiopia. In a small town ~4% of individuals had symptoms suggestive of asthma and this correlated strongly with positive skin tests to dust mite (odds ratio 10.9, confidence interval 6.4-18.9). By contrast, in the rural population 119 individuals had positive skin tests to dust mite and none of these had symptoms of wheeze or asthma.
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Yemaneberhan H, Bekele Z, Venn A, Lewis S, Parry E, Britton J. Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia. of special interest Lancet. 350:1997;85-90 This provides a comparison of respiratory symptoms and skin tests to common allergens in two populations in Ethiopia. In a small town ~4% of individuals had symptoms suggestive of asthma and this correlated strongly with positive skin tests to dust mite (odds ratio 10.9, confidence interval 6.4-18.9). By contrast, in the rural population 119 individuals had positive skin tests to dust mite and none of these had symptoms of wheeze or asthma.
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(1997)
Lancet
, vol.350
, pp. 85-90
-
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Yemaneberhan, H.1
Bekele, Z.2
Venn, A.3
Lewis, S.4
Parry, E.5
Britton, J.6
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36
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Leung R, Ho P. Asthma and atopy in three southeast Asian populations. Thorax. 49:1994;1205-1210.
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Thorax
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Leung, R.1
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37
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Broder I, Higgins MW, Mathews KP, Keller JB. Epidemiology of asthma and allergic rhinitis in a total community, Tecumseh, Michigan, III: second survey of the community. J Allerg Clin Immunol. 53:1974;127-138.
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Hagy GW, Settipane GA. Bronchial asthma, allergic rhinitis and allergy skin tests among college students. J Allerg. 44:1969;323-332.
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Hagy, G.W.1
Settipane, G.A.2
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40
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The relative risks of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma
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Sears MR, Herbison GP, Holdaway MD, Hewitt CJ, Flannery EM, Silva PA. The relative risks of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma. Clin Experiment Allergy. 19:1989;419-424.
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Sears, M.R.1
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Silva, P.A.6
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41
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0029033456
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Association of asthma with serum IgE and skin-test reactivity to allergens among children living at high altitude
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Sporik R, Ingram JM, Price W, Sussman JH, Honsinger RW, Platts-Mills TAE. Association of asthma with serum IgE and skin-test reactivity to allergens among children living at high altitude. Am J Respir Crit Care Med. 151:1995;1388-1392.
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Sporik, R.1
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42
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Sensitization to dust mites as a dominant risk factor for adolescent asthma
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of special interest. This describes a survey of 1034 middle-school children in Virginia; it identified 134 with symptoms of asthma. Testing with histamine further defined 46 with symptomatic bronchial reactivity (or asthma). Logistic regression identified sensitization to dust mite, but not the actual concentration of allergen in the child's house, as a major risk factor for asthma. By contrast sensitization to pollens, total IgE and passive smoke exposure were not independent risk factors for asthma.
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Squillace SP, Sporik RB, Rakes G, Couture N, Lawrence A, Merriam S, Zhang J, Platts-Mills TAE. Sensitization to dust mites as a dominant risk factor for adolescent asthma. of special interest Am J Respir Crit Care Med. 156:1997;1760-1764 This describes a survey of 1034 middle-school children in Virginia; it identified 134 with symptoms of asthma. Testing with histamine further defined 46 with symptomatic bronchial reactivity (or asthma). Logistic regression identified sensitization to dust mite, but not the actual concentration of allergen in the child's house, as a major risk factor for asthma. By contrast sensitization to pollens, total IgE and passive smoke exposure were not independent risk factors for asthma.
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Am J Respir Crit Care Med
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Squillace, S.P.1
Sporik, R.B.2
Rakes, G.3
Couture, N.4
Lawrence, A.5
Merriam, S.6
Zhang, J.7
Platts-Mills, T.A.E.8
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43
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Risk factors for asthma in inner city children
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Call RS, Smith TF, Morris E, Chapman MD, Platts-Mills TAE. Risk factors for asthma in inner city children. J Pediat. 121:1992;862-866.
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44
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0031003334
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The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma
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of outstanding interest. This reports the National Co-operative Inner City Asthma Study investigation of a cohort of inner-city children whose houses were visited and who were skin tested. The strongest predictor of hospitalization for asthma among these children was the combination of a positive skin test for cockroach allergen and elevated levels of the cockroach allergen Bla g 2 in the children's bedrooms. In this study, dust mite and cat allergen levels in these city apartments were low and did not appear to be relevant to severity.
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Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, Mitchell H, McNiff-Mortimer K, Lynn H, Ownby D, Malveaux F. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. of outstanding interest N Engl J Med. 336:1997;1356-1363 This reports the National Co-operative Inner City Asthma Study investigation of a cohort of inner-city children whose houses were visited and who were skin tested. The strongest predictor of hospitalization for asthma among these children was the combination of a positive skin test for cockroach allergen and elevated levels of the cockroach allergen Bla g 2 in the children's bedrooms. In this study, dust mite and cat allergen levels in these city apartments were low and did not appear to be relevant to severity.
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N Engl J Med
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Rosenstreich, D.L.1
Eggleston, P.2
Kattan, M.3
Baker, D.4
Slavin, R.G.5
Gergen, P.6
Mitchell, H.7
McNiff-Mortimer, K.8
Lynn, H.9
Ownby, D.10
Malveaux, F.11
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45
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Effect of alterations in dietary sodium on the severity of asthma in men
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Carey OJ, Locke C, Cookson JB. Effect of alterations in dietary sodium on the severity of asthma in men. Thorax. 48:1993;714-718.
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Thorax
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Carey, O.J.1
Locke, C.2
Cookson, J.B.3
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46
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0029054413
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A prospective study of diet and adult onset asthma
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Troisi RJ, Willet WC, Weiss ST, Trichopoulos D, Rosner B, Speizer FE. A prospective study of diet and adult onset asthma. Am J Respir Crit Care Med. 151:1995;1401-1408.
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Troisi, R.J.1
Willet, W.C.2
Weiss, S.T.3
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Speizer, F.E.6
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47
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0003441938
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Anonymous. Washington DC: US Bureau of the Census
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Anonymous Statistical Abstract of the United States. 1997;US Bureau of the Census, Washington DC.
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Statistical Abstract of the United States
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48
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0029872723
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Television watching as a cause of increased obesity among children in the United States
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Gortmaker SL, Must A, Sobol AM, Peterson K, Colditz GA, Dietz WH. Television watching as a cause of increased obesity among children in the United States. Arch Pediatr Adolesc Med. 150:1996;356-362.
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Gortmaker, S.L.1
Must, A.2
Sobol, A.M.3
Peterson, K.4
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Dietz, W.H.6
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49
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Overweight children and adolescents: Description, epidemiology, and demographics
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Troiano RP, Flegal KM. Overweight children and adolescents: description, epidemiology, and demographics. Pediatrics. 101:1998;497-504.
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Pediatrics
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Troiano, R.P.1
Flegal, K.M.2
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50
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0031925581
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Association of being overweight with greater asthma symptoms in inner city Black and Hispanic children
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of outstanding interest. This comparison of asthmatic children in New York City with results of the Third National Health and Nutrition Survey (NHANES) demonstrated that children with moderate to severe asthma were more obese both than comparable children nationally and than other children in New York. This is the first clear evidence of an epidemiological association of obesity with asthma and provides evidence for a change in the phenotype of asthmatics.
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Luder E, Melnik TA, DiMaio M. Association of being overweight with greater asthma symptoms in inner city Black and Hispanic children. of outstanding interest J Pediat. 132:1998;699-703 This comparison of asthmatic children in New York City with results of the Third National Health and Nutrition Survey (NHANES) demonstrated that children with moderate to severe asthma were more obese both than comparable children nationally and than other children in New York. This is the first clear evidence of an epidemiological association of obesity with asthma and provides evidence for a change in the phenotype of asthmatics.
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(1998)
J Pediat
, vol.132
, pp. 699-703
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Luder, E.1
Melnik, T.A.2
Dimaio, M.3
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51
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0030629613
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The role of domestic allergens
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of special interest. In this article we introduced the idea that decreased physical exercise could have contributed to the increase in asthma; however, it is clear that the effect of this change has been to increase the risk associated with chronic exposure to indoor allergens. The protective effect associated with exercise might be related to the efficiency of the repair process following allergen exposure. This repair process would be crucial for responses to perennial allergens, as opposed to seasonal allergens.
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Platts-Mills TAE, Sporik RB, Chapman MD, Heymann PW. The role of domestic allergens. of special interest Ciba Found Symp. 206:1997;173-185 In this article we introduced the idea that decreased physical exercise could have contributed to the increase in asthma; however, it is clear that the effect of this change has been to increase the risk associated with chronic exposure to indoor allergens. The protective effect associated with exercise might be related to the efficiency of the repair process following allergen exposure. This repair process would be crucial for responses to perennial allergens, as opposed to seasonal allergens.
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(1997)
Ciba Found Symp
, vol.206
, pp. 173-185
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Platts-Mills, T.A.E.1
Sporik, R.B.2
Chapman, M.D.3
Heymann, P.W.4
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52
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Effect of a previous deep inspiration on airway resistance in man
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Nadel JA, Tierney DF. Effect of a previous deep inspiration on airway resistance in man. J Appl Physiol. 16:1961;717-719.
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Nadel, J.A.1
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