An inhibitor of nitric oxide synthase does not increase contraction or β-adrenoceptor sensitivity of ventricular myocytes from failing human heart

Cardiovascular Research

Volumn 40, Issue 3, 1998, Pages 523-529

  Harding, Sian E ^a   Davies, Crispin H ^a,b   Money Kyrle, Andrew M ^a   Poole Wilson, Philip A ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Contractility; Frequency; Heart failure; Human; Nitric oxide

Indexed keywords

BETA ADRENERGIC RECEPTOR; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ARTICLE; CALCIUM CELL LEVEL; CELL ISOLATION; HEART CONTRACTION; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; RECEPTOR SENSITIVITY;

ADRENERGIC BETA-AGONISTS; ADULT; AGED; ANALYSIS OF VARIANCE; CELL SIZE; CELLS, CULTURED; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; FEMALE; HEART DISEASES; HUMANS; ISOPROTERENOL; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; MYOCARDIUM; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; RECEPTORS, ADRENERGIC, BETA;

EID: 0032403778     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(98)00188-6     Document Type: Article

References (26)

1. Bohm M., La Rosee K., Schmidt U.et al. Force-frequency relationship and inotropic stimulation in the nonfailing and failing human myocardium: implications for the medical treatment of heart failure. Clin Invest. 70:1992;421-425.
2. Mulieri L.A., Hasenfuss G., Leavitt B.J., Allen P.D., Alpert N.R. Altered myocardial force-frequency relation in human heart failure. Circulation. 85:1992;1743-1750.
3. Davies C.H., Davia K., Bennett J.G.et al. Reduced contraction and altered frequency response of isolated ventricular myocytes from patients with heart failure. Circulation. 92:1995;2540-2549.
4. Lamas S., Marsden P.A., Li G.K., Tempst P., Michel T. Endothelial nitric oxide synthase: molecular cloning and characterisation of a distinct constitutive enzyme isoform. Proc Natl Acad Sci USA. 89:1992;6348-6352.
5. Brady A.J., Warren J.B., Poole-Wilson P.A., Williams T.J., Harding S.E. Nitric oxide attenuates cardiac myocyte contraction. Am J Physiol. 265:1993;H176-H182.
6. Finkel M.S., Oddis C.V., Mayer O.H., Hattler B.G., Simmons R.L. Nitric oxide synthase inhibitor alters papillary muscle force-frequency relationship. J Pharmacol Exp Ther. 272:1995;945-952.
7. Kaye D.M., Wiviott S.D., Balligand J.L.et al. Frequency-dependent activation of a constitutive nitric oxide synthase and regulation of contractile function in adult rat ventricular myocytes. Circ Res. 78:1996;217-224.
8. Brady A.J.B., Warren J.B., Harding S.E., Poole-Wilson P.A. Contractility of human and guinea-pig cardiac ventricular myocytes is modified by mechanisms involving nitric oxide (Abstract). Br Heart J. 69(5):1993;9.
9. Flesch M., Kilter H., Cremers B.et al. Acute effects of nitric oxide and cyclic GMP on human myocardial contractility. J Pharmacol Exp Ther. 281:1997;1340-1349.
10. Ungureanu-Longrois D., Balligand J.L., Okada I.et al. Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. Circ Res. 77:1995;486-493.
11. Balligand J.L., Ungureanu-Longrois D., Simmons W.W.et al. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J Biol Chem. 269:1994;27580-27588.
12. Brady A.J.B., Poole-Wilson P.A., Harding S.E., Warren J.B. Nitric oxide production within myocytes reduces their contractility in endotoxaemia. Am J Physiol. 263:1992;H1963-H1966.
13. de Belder A.J., Radomski M.W., Why H.J.et al. Nitric oxide synthase activities in human myocardium. Lancet. 341:1993;84-85.
14. de Belder A.J., Radomski M.W., Why H.J., Richardson P.J., Martin J.F. Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and postpartum cardiomyopathy but not in ischaemic or valvar heart disease. Br Heart J. 74:1995;426-430.
15. Habib F.M., Springall D.R., Davies G.J.et al. Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy [see comments]. Lancet. 347:1996;1151-1155.
16. Hare J.M., Loh E., Creager M.A., Colucci W.S. Nitric oxide inhibits the positive inotropic response to beta-adrenergic stimulation in humans with left ventricular dysfunction. Circulation. 92:1995;2198-2203.
17. Yamamoto S., Tsutsui H., Tagawa H.et al. Role of myocyte nitric oxide in beta-adrenergic hyporesponsiveness in heart failure. Circulation. 95:1997;1111-1114.
18. Thoenes M., Forstermann U., Tracey W.R.et al. Expression of inducible nitric oxide synthase in failing and non-failing human heart. J Mol Cell Cardiol. 28:1996;165-169.
19. Haywood G.A., Tsao P.S., Heiko E.et al. Expression of inducible nitric oxide synthase in human heart failure. Circulation. 93:1996;1087-1094.
20. Harding S.E., Jones S.M., O'Gara P.et al. Isolated ventricular myocytes from failing and non-failing human heart; the relation of age and clinical status of patients to isoproterenol response. J Mol Cell Cardiol. 24:1992;549-564.
21. del Monte F., O'Gara P., Poole-Wilson P.A., Yacoub M.H., Harding S.E. Cell geometry and contractile abnormalities of myocytes from failing human left ventricle. Cardiovasc Res. 30:1995;281-290.
22. Winlaw D.S., Smythe G.A., Keogh A.M.et al. Increased nitric oxide production in heart failure. Lancet. 344:1994;373-374.
23. Luss H., Li R.K., Shapiro R.A.et al. Dedifferentiated human ventricular cardiac myocytes express inducible nitric oxide synthase mRNA but not protein in response to IL-1, TNF, IFNgamma, and LPS. J Mol Cell Cardiol. 29:1997;1153-1165.
24. Harding S.E., Brown L.A., Wynne D.G., Davies C.H., Poole-Wilson P.A. Mechanisms of beta-adrenoceptor desensitisation in the failing human heart. Cardiovasc Res. 28:1994;1451-1460.
25. Hasenfuss G., Reinecke H., Studer R.et al. Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium. Circ Res. 75:1994;434-442.
26. Davia K., Davies C.H., Harding S.E. Effects of inhibition of sarcoplasmic reticulum calcium uptake on contraction of myocytes from failing human ventricle. Cardiovasc Res. 33:1997;88-97.