Engagement of ICAM-3 activates polymorphonuclear leukocytes: Aggregation without degranulation or integrin recruitment

Journal of Immunology

Volumn 161, Issue 11, 1998, Pages 6280-6287

  Feldhaus, Michael J ^a,b   Kessel, Julie M ^a   Zimmerman, Guy A ^a   McIntyre, Thomas M ^a,c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b Ventana Genetics Inc   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FORMYLMETHIONYLLEUCYLPHENYLALANINE; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 3; MONOCLONAL ANTIBODY; PROTEIN KINASE C; PROTEIN TYROSINE KINASE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; LEUKOCYTE AGGREGATION; NEUTROPHIL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CALCIUM; CELL ADHESION MOLECULES; CELL AGGREGATION; CELL DEGRANULATION; CYTOPLASMIC GRANULES; CYTOSKELETON; EPITOPES; HUMANS; INTRACELLULAR FLUID; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; NEUTROPHIL ACTIVATION; NEUTROPHILS; PHOSPHORYLATION; RECEPTOR AGGREGATION; SERINE; SIGNAL TRANSDUCTION; TYROSINE;

EID: 0032403495     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Figdor, C. G., M. Lub, and Y. van Kooyk. 1995. Ins and outs of LFA-1. Immunol. Today 16:479.
2. Shattil, S. J., and M. H. Ginsberg. 1997. Intergrin signaling in vascular biology. J. Clin. Invest. 100:1.
3. Staunton, D. E., S. D. Marlin, C. Stratowa, M. L. Dustin, and T. A. Springer. 1988. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell 52:925.
4. Simmons, D., M. W. Makgoba, and B. Seed. 1988. ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature 331:624.
5. Vazeux, R., P. A. Hoffman, J. K. Tomita, E. S. Dickinson, R. L. Jasman, T. St. John, and W. M. Gallatin. 1992. Cloning and characterization of a new intercellular adhesion molecule ICAM-R. Nature 360:485.
6. Fawcett, J., C. L. L. Holness, L. A. Needham, H. Turley, K. C. Gatter, D. Y. Mason, and D. L. Simmons. 1992. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. Nature 360:481.
7. de Fougerolles, A. R., and T. A. Springer. 1992. Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. J. Exp. Med. 175:185.
8. Diamond, M. S., D. E. Staunton, S. D. Marlin, and T. A. Springer. 1991. Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Cell 65:961.
9. Staunton, D. E., M. L. Dustin, H. P. Erickson, and T. A. Springer. 1990. The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. Cell 61:243.
10. Klickstein, L. B., M. R. York, A. R. de Fougerolles, and T. A. Springer. 1996. Localization of the binding site on intercellular adhesion molecule-3 (ICAM-3) for lymphocyte function-associated antigen 1 (LFA-1). J. Biol. Chem. 271:23920.
11. Damle, N. K., K. Klussman, and A. Aruffo. 1992. Intercellular adhesion molecule-2: a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1) provides a costimulatory signal for T-cell receptor-initiated activation of human T cells. J. Immunol. 148:665.
12. Bossy, D., C. D. Buckley, C. L. Holness, A. J. Littler, N. Murray, I. Collins, and D. L. Simmons. 1995. Epitope mapping and functional properties of anti-intercellular adhesion molecule-3 (CD50) monoclonal antibodies. Eur. J. Immunol. 25:459.
13. 2 integrin function. Eur. J. Immunol. 24:1377.
14. Campanero, M. R., P. Sanchez-Mateos, M. A. del Pozo, and F. Sanchez-Madrid. 1994. ICAM-3 regulates lymphocyte morphology and integrin-mediated T cell interaction with endothelial cell and extracellular matrix ligands. J. Cell Biol. 127:867.
15. Arroyo, A. G., R. Campanero, P. Sanchez-Mateos, J. M. Zapata, M. A. Ursa, M. A. del Pozo, and F. Sanchez-Madrid. 1994. Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase. J. Cell Biol. 126:1277.
16. de Fougerolles, A. R., M. S. Diamond, and T. A. Springer. 1995. Heterogenous glycosylation of ICAM-3 and lack of interaction with Mac-1 and p150,95. Eur. J. Immunol. 25:1008.
17. lck in Jurkat T cell line. J. Exp. Med. 179:1747.
18. del Pozo, M. A., R. Pulido, C. Munoz, V. Alvarez, A. Humbria, M. R. Campanero, and F. Sanchez-Madrid. 1994. Regulation of ICAM-3 (CD50) membrane expression on human neutrophils through a proteolytic shedding mechanism. Eur. J. Immunol. 24:2586.
19. Skubitz, K. M., K. D. Campbell, and A. P. N. Skubitz. 1997. CD50 monoclonal antibodies inhibit neutrophil activation. J. Immunol. 159:820.
20. Zimmerman, G. A., T. M. McIntyre, and S. M. Prescott. 1985. Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. J. Clin. Invest. 76:2235.
21. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
22. Hughes, B. J., J. C. Hollers, E. Crockett-Torabi, and C. W. Smith. 1992. Recruitment of CD11b/CD18 to the neutrophil surface and adherence-dependent cell locomotion. J. Clin. Invest. 90:1687.
23. Zimmerman, G. A., and T. M. McIntyre. 1988. Neutrophil adherence to human endothelium in vitro occurs by CDw18 (Mol, MAC-1/LFA-1/GP 150,95) glycoprotein-dependent and -independent mechanisms. J. Clin. Invest. 81:531.
24. Borregaard, N., L. Kjeldsen, H. Sengelov, M. S. Diamond, T. A. Springer, H. Clarke-Anderson, T. K. Kishimoto, and D. F. Baint. 1994. Changes in subcellular localization and surface expression L-selectin, alkaline phosphatase, and Mac-1 in human neutrophils during stimulation with inflammatory mediators. J. Leukocyte Biol. 56:80.
25. 2, binds preferentially to ICAM-3. Immunity 3:683.
26. Campanero, M. R., M. A. del Pozo, A. G. Arroyo, P. Sanchez-Mateos, T. Hernandez-Caselles, A. Craig, R. Pulido, and F. Sanchez-Madrid. 1993. ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway. J. Cell Biol. 123:1007.
27. Okuyama, M., J. Kambayashi, M. Sakon, and M. Monden. 1996. LFA-1/ICAM-3 mediates neutrophil homotypic aggregation under fluid shear stress. J. Cell. Biochem. 60:550.
28. Kessel, J. M., J. Hayflick, A. S. Weyrich, P. A. Hoffman, M. Gallatin, T. M. McIntyre, S. M. Prescott, and G. A. Zimmerman. 1998. Coengagement of ICAM-3 and Fc receptors induces chemokine secretion and spreading by myeloid leukocytes. J. Immunol. 160:5579.
29. Skubitz, K. M., K. Ahmed, K. D. Campbell, and A. P. N. Skubitz. 1995. CD50 (ICAM-3) is phosphorylated on tyrosine and is associated with tyrosine kinase activity in human neutrophils. J. Immunol. 154:2888.
30. Francis, J. W., R. F. Todd, L. A. Boxer, and H. R. Petty. 1989. Sequential expression of cell surface C3bi receptors during neutrophil locomotion. J. Cell Biol. 140:519.
31. Schleiffenbaum, B., R. Moser, M. Patarroyo, and J. Fehr. 1989. The cell surface glycoprotein Mac-1 (CD11b/CD18) mediates neutrophil adhesion and modulates degranulation independently of its quantitative cell surface expression. J. Immunol. 142:3537.