A critical role for CD48 antigen in regulating alloengraftment and lymphohematopoietic recovery after bone marrow transplantation

Blood

Volumn 92, Issue 11, 1998, Pages 4453-4463

  Blazar, Bruce R ^a   Taylor, Patricia A ^b   Panoskaltsis Mortari, Angela ^b   Yagita, Hideo ^b   Bromberg, Jonathan S ^b   Vallera, Daniel A ^b  

^a UNIV OF MINNESOTA HOSP AND CLINIC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD48 ANTIGEN; CD8 ANTIGEN; MONOCLONAL ANTIBODY;

ALLOGRAFT; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; COLONY FORMING UNIT S; CONTROLLED STUDY; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HEMATOPOIESIS; HEMATOPOIETIC CELL; NONHUMAN; PRIORITY JOURNAL;

EID: 0032402157     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.11.4453     Document Type: Article

References (28)

1. Howard FD, Ledbetter JA, Wong J, Bieber CP, Stinson EB, Herzenberg LA: A human T lymphocyte differentiation marker defined by monoclonal antibodies that block E-rosette formation. J Immunol 126:2117, 1981
2. Kamoun M, Kadin ME, Martin PJ, Nettleton J, Hansen JA: A novel human T cell antigen preferentially expressed on mature T cells and shared by both well and poorly differentiated B cell leukemias and lymphomas. J Immunol 127:987, 1981
3. Bernard A, Gelin C, Raynal B, Pham D, Gosse C, Boumsell L: Phenomenon of human T cells rosetting with sheep erythrocytes analyzed with monoclonal antibodies. "Modulation" of a partially hidden epitope determining the conditions of interaction between T cells and erythrocytes. J Exp Med 155:1317, 1982
4. Sewell WA, Brown MH, Owen MJ, Fink PJ, Kozak CA, Crumpton MJ: The murine homologue of the T lymphocyte CD2 antigen: Molecular cloning, chromosome assignment and cell surface expression. Eur J Immunol 17:1015, 1987
5. Yagita H, Asakawa J, Tansyo S, Nakamura T, Habu S, Okumura K: Expression and function of CD2 during murine thymocyte ontogeny. Eur J Immunol 19:2211, 1989
6. Beyers AD, Barclay AN, DA, He Q, Williams AF: Activation of T lymphocytes via monoclonal antibodies against rat cell surface antigens with particular reference to CD2 antigen. Immunol Rev 111:59, 1989
7. Bierer BE, Burakoff SJ: T-lymphocyte activation: The biology and function of CD2 and CD4. Immunol Rev 111:267, 1989
8. Bell GM, Imboden JB: CD2 and the regulation of T cell anergy. J Immunol 155:2805, 1995
9. Guckel B, Berek C, Lutz M, Altevogt P, Schirrmacher V, Kyewsi BA: Anti-CD2 antibodies induce T cell unresponsiveness in vivo. J Exp Med 174:957, 1991
10. Kalo K, Koyanagi M, Okada H, Takanashi T, Wong YW, Williams AF, Okumura K, Yagita H: CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. J Exp Med 176:1241, 1992
11. Bromberg JS, Chavin KD, Altevogt P, Kyewski BA, Guckel B, Naji A, Barker CF: Anti-CD2 monoclonal antibodies alter cell-mediated immunity in vivo. Transplantation 51:219, 1991
12. Chavin KD, Lau HT, Bromberg JS: Prolongation of allograft and xenograft survival in mice by anti-CD2 monoclonal antibodies. Transplantation 54:286, 1992
13. Cabrero JG, Freeman GH, Lane WS, Reiser H: Identification, by protein sequencing and gene transfection, of sgp-60 as the murine homologue of CD48. Proc Natl Acad Sci USA 90:3418, 1993
14. Qin L, Chavin KD, Lin J, Yagita H, Bromberg JS: Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. J Exp Med 179:341, 1994
15. Yagita H, Nakamura T, Karasuyama H, Okumura K: Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells. Proc Natl Acad Sci USA 86:645, 1989
16. + cells. J Exp Med 180:307, 1994
17. Blazar BR, Taylor PA, Linsley PS, Vallera DA: In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex (MHC) barrier in mice. Blood 83:3815, 1994
18. Mantel N: Evaluation of survival data in two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163, 1966
19. Blazar BR, Hirsch R, Gress RE, Carroll SF, Vallera DA: In vivo administration of monoclonal antibodies or immunotoxins in murine recipients of allogeneic T-cell depleted marrow for the promotion of engraftment. J Immunol 147:1492, 1991
20. Yokoyama S, Staunton D, Fisher R, Amiot M, Fortin JJ, Thorley-Lawson DA: Expression of the Blast-1 activation/adhesion molecule and its identification as CD48. J Immunol 146:2192, 1991
21. Killeen N, Moessner R, Arvieux J, Willis A, Williams AF: The MRC OX-45 antigen of rat leukocytes and endothelium is in a subset of the immunoglobulin superfamily with CD2, LFA-3 and carcinoembryonic antigens. EMBO J 7:3087, 1988
22. Wong YW, Williams AF, Kingsmore SF, Seldin MF: Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3. J Exp Med 171:2115, 1990
23. Chavin KD, Qin L, Lin J, Woodward J, Baliga P, Kato K, Yagita H, Bromberg JS: Anti-CD48 (murine CD2 ligand) mAbs suppress cell mediated immunity in vivo. Int Immunol 6:701, 1994
24. Chavin KD, Lau HT, Bromberg JS: Prolongation of allograft and xenograft survival in mice by anti-CD2 monoclonal antibodies. Transplantation 54:286, 1992
25. Chavin KD, Qin L, Lin Y, Yagita H, Bromberg JS: Combined anti-CD2 and anti-CD3 receptor monoclonal antibodies induce donor-specific tolerance in a cardiac transplant model. J Immunol 151:7249, 1993
26. Chavin KD, Qin L, Yon R, Lin J, Yagita H, Bromberg JS: Anti-CD2 mAbs suppress cytotoxic lymphocyte activity by the generation of Th2 suppressor cells and receptor blockade. J Immunol 152:3729, 1994
27. Ayroldi E, Migliorati G, Cannarile L, Moraca R, Delfino DV, Riccardi C: CD2 rescues T cells from T-cell receptor/CD3 apoptosis: A role for the Fas/Fas-L system. Blood 89:3717, 1997
28. Graubert TA, Dipersio JF, Russell JH, Ley TJ: Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest 100:904, 1997