Mechanisms of vasorelaxation induced by troglitazone, a novel antidiabetic drug, in the porcine coronary artery

Circulation

Volumn 98, Issue 22, 1998, Pages 2446-2452

  Kawasaki, Junya ^a   Hirano, Katsuya ^a   Nishimura, Junji ^a   Fujishima, Masatoshi ^a   Kanaide, Hideo ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Calcium channels; Diabetes mellitus; Fura 2; Vasodilation

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANTIDIABETIC AGENT; POTASSIUM CHANNEL; TROGLITAZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CHANNEL GATING; CORONARY ARTERY; DATA ANALYSIS; FLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SWINE; VASODILATATION;

EID: 0032401699     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.98.22.2446     Document Type: Article

References (22)

1. Bressler R, Johnson DG. Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus. Arch Intern Med. 1997; 157:836-848.
2. Kellerer M, Kroder G, Tippmer S, Berti L, Kiehn R, Mosthaf L, Haring H. Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblasts. Diabetes. 1994;43:447-453.
3. Yoshioka S, Nishino H, Shiraki T, Ikeda K, Koike H, Okuno A, Wada M, Fujiwara T, Horikoshi H. Antihypertensive effects of CS-045 treatment in obese Zucker rats. Metab Clin Exp. 1993;42:75-80.
4. Ogihara T, Rakugi H, Ikegami H, Mikami H, Masuo K. Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives. Am J Hypertens. 1995;8:316-320.
5. 2+ currents and not endothelial nitric oxide production. Diabetes. 1997;46:659-664.
6. Buchanan TA, Meehan WP, Jeng YY, Yang D, Chan TM, Nadler JL, Scott S, Rude RK, Hsueh WA. Blood pressure lowering by pioglitazone: evidence for a direct vascular effect. J Clin Invest. 1995;96:354-360.
7. Abe S, Kanaide H, Nakamura M. Front-surface fluorometry with fura 2 and effects of nitroglycerin on cytosolic calcium concentrations and on tension in the coronary artery of the pig. Br J Pharmacol. 1990;101: 545-552.
8. Hirano K, Kanaide H, Abe S, Nakamura M. Effects of diltiazem on calcium concentrations in the cytosol and on force of contractions in porcine coronary arterial strips. Br J Pharmacol. 1990;101:273-280.
9. Ushio FM, Abe S, Kobayashi S, Nishimura J, Kanaide H. Effects of isoprenaline on cytosolic calcium concentrations and on tension in the porcine coronary artery. J Physiol. 1993;462:679-696.
10. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985; 260:3440-3450.
11. Miyagi Y, Kobayashi S, Nishimura J, Fukui M, Kanaide H. Resting load regulates cytosolic calcium-force relationship of the contraction of bovine cerebrovascular smooth muscle. J Physiol. 1995;484(pt 1):123-137.
12. Hallam TJ, Jacob R, Merritt JE. Evidence that agonists stimulate bivalentcation influx into human endothelial cells. Biochem J. 1988;255:179-184.
13. Ca channel activity from pig coronary artery. Am J Physiol. 1992;262:C708- C713.
14. Nelson MT, Standen NB, Brayden JE, Worley JF 3d. Noradrenaline contracts arteries by activating voltage-dependent calcium channels. Nature. 1988;336:382-385.
15. Bolton TB. Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev. 1979;59:606-718.
16. Putney JW Jr. Capacitative calcium entry revisited. Cell Calcium. 1990; 11:611-624.
17. Merritt JE, Armstrong WP, Benham CD, Hallam TJ, Jacob R, JaxaChamiec A, Leigh BK, McCarthy SA, Moores KE, Rink TJ. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem J. 1990;271:515-522.
18. Kawasaki J, Kobayashi S, Miyagi Y, Nishimura J, Fujishima M, Kanaide H. The mechanisms of the relaxation induced by vasoactive intestinal peptide in the porcine coronary artery. Br J Pharmacol. 1997;121: 977-985.
19. Di Salvo J, Nelson SR, Kaplan N. Protein tyrosine phosphorylation in smooth muscle: a potential coupling mechanism between receptor activation and intracellular calcium. Proc Soc Exp Biol Med. 1997;214: 285-301.
20. Kureishi Y, Kobayashi S, Amano M, Kimura K, Kanaide H, Nakano T, Kaibuchi K, Ito M. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem. 1997;272:12257-12260.
21. Nishimura J, van Breemen C. Direct regulation of smooth muscle contractile elements by second messengers. Biochem Biophys Res Commun. 1989;163:929-935.
22. Horikoshi H, Yoshioka T, Kawasaki T, Nakamura K, Matsunuma N, Yamaguchi K, Sasahara K. Troglitazone (CS-045), a new antidiabetic drug. Sankyo Kenkyusho Nenpo (Annu Rep Sankyo Res Lab.). 1994; 46:1-57.