Estrogens and the cardiovascular system: Role of estradiol metabolites in hormone replacement therapy

Climacteric

Volumn 1, Issue 4, 1998, Pages 296-301

  Lippert, T H ^a,b   Seeger, H ^a   Mueck, A O ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Section of Clinical Pharmacology   (Germany)

Author keywords

Cardiovascular System; Estradiol Metabolites; Estradiol Replacement Therapy; Postmenopause

Indexed keywords

ESTRADIOL; ESTROGEN;

ANIMAL; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; DRUG EFFECT; ESTROGEN THERAPY; FEMALE; HUMAN; METABOLISM; PHYSIOLOGY; POSTMENOPAUSE; REVIEW;

ANIMALS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; HUMANS; POSTMENOPAUSE;

EID: 0032400593     PISSN: 13697137     EISSN: None     Source Type: Journal    
DOI: 10.3109/13697139809085558     Document Type: Article

References (33)

1. Kannel BW, Hjortland MC, McNamara PM, et al. Menopause and risk of cardiovascular disease. The Framingham Study. Ann Intern Med 1976;85:447-52
2. Lippert TH, Mueck AO, Ginsburg J, eds. Sex Steroids and the Cardiovascular System. London: Parthenon Publishing, 1997
3. Hoffmann AR, Paul SM, Axelrod J. Estrogen-2 hydroxylase in the rat: distribution and response to hormonal manipulation. Biochem Pharmacol 1980;29:83-7
4. Van Orden DE, Clancey CJ, Van Orden CL, et al. Synthesis of catechol estrone by porcine uterine arteries. Presented at the Endocrine Society, 1983:abstr 30
5. Van Orden DE, Ford SP, Farley DB, et al. Induction of uterine arterial vasodilation by estradiol and catechol estradiols. Proc Soc Gynecol Invest 1983;30:abstr 58
6. Ford SP, Van Orden DE, Farley CB. Effect of cycloheximide on catechol estrogen induced uterine hyperemia. Proc Soc Gynecol Invest 1986;33:abstr 378
7. 2+ uptake of uterine arterial smooth muscle cells through potential-sensitive channels. Biol Reprod 1987; 36:361-8
8. 2+ channels in altering uterine blood flow during the estrous cycle and early pregnancy in gilts. Biol Reprod 1987;36:369-75
9. Heinle H, Orth N, Neeser E, et al. Effects of 17β-estradiol and its catechol metabolites on the contractility of human uterine artery: in vitro experiments. In Lippert TH, Mueck AO, Ginsburg J, eds. Sex Steroids and the Cardiovascular System. London: Parthenon Publishing, 1997:75-83
10. Orth N, Neeser E, Seeger H, et al. Calcium antagonistic effect of estrogen and estrogen metabolites in smooth muscle: evidence from contraction measurements and intracellular calcium imageing. Pflügers Arch Eur J Physiol 1998;435(Suppl):R204
11. Ross R. The pathogenesis of atherosclerosis - an update. N Engl J Med 1986;314:488-500
12. Fotsis T, Zhang Y, Pepper MS, et al. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature (London) 1994;368:237-9
13. Nishigaki I, Sasaguri Y, Yagi K. Antiproliferative effect of 2-methoxyestradiol on cultured smooth muscle cells from rabbit aorta. Atherosclerosis 1995;113:167-70
14. Seeger H, Mueck AO, Lippert TH. The antiproliferative effect of 17β-estradiol metabolites on human coronary artery smooth muscle cells. Med Sci Res 1998;26:481-2
15. Bradlow HL, Telang NT, Sepkovic DW, et al. 2-Hydroxyestrone: the 'good' estrogen. J Endocrinol 1996;150:S259-65
16. Oettel M, Dören M, Hübler D, et al. Freie Radikale und Sexualhormone. J Menopause 1995;3:21-8
17. Sack MN, Rader DJ, Cannon RO. Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet 1994;343:269-70
18. Bush TL, Barrett-Connor E, Cowan LD, et al. Cardiovascular mortality and noncontraceptive use of estrogen in women: results from the Lipid Research Clinics Program Follow-up Study. Circulation 1987;75:1102-9
19. Gordon S, Cantrall EW, Cekleniak WP, et al. Steroid and lipid metabolism. The hypocholesteremic effect of estrogen metabolites. Steroids 1964;4:267-71
20. Kono S, Higa H, Sunagawa H. Effects of catecholestrogen 2-monomethyl ether on serum cholesterol and lipoprotein levels. Asia-Oceania J Obstet Gynaecol 1988;14:399-403
21. Liu DF, Bachmann KA. An investigation of the relationship between estrogen, estrogen metabolites and blood cholesterol levels in ovariectomized rats. J Pharmacol Exp Ther 1998;286: 561-8
22. 2+-catalyzed oxidation of low or high density lipoprotein: antioxidative effects of steroids on lipoproteins. Endocr J 1994; 41:605-11
23. Lacorte M, Leal AM, Liza M, et al. Protective effect of estrogens and catecholestrogens against peroxidative membrane damage in vitro. Lipids 1995;30:141-6
24. Esterbauer H, Striegl G, Puhl H, et al. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Rad Res Comm 1989;6: 67-75
25. Seeger H, Mueck AO, Lippert TH. Effect of estradiol metabolites on the susceptibility of low density lipoprotein to oxidation. Life Sci 1997; 61:865-8
26. Seeger H, Mueck AO, Lippert TH. The inhibitory effect of endogenous estrogen metabolites on copper-mediated in vitro oxidation of LDL. Int J Clin Pharmacol Ther 1998;36:383-5
27. Fishman J, Martucci C. Dissociation of biological activities in metabolites of estradiol. In McLachlan JA, ed. Estrogens in the Environment. North Holland: Elsevier, 1980:131-45
28. Zumoff B, Fishman J, Cassouto J, et al. Influence of age and sex on normal estradiol metabolism. 7 Clin Endocrinol 1968;28:937-41
29. Zumoff B, Fishman J, Cassouto J, et al. Estradiol transformation in men with breast cancer. J Clin Endocrinol 1966;26:960-7
30. Habenicht UF. Estrogens for men: good or bad news. Aging Male 1998;l:73-9
31. Friedl KE, Hannan CJ, Jines RE, et al. High density lipoprotein-cholesterol is not decreased if an aromatizable androgen is administered. Metabolism 1990;39:69-74
32. Bradlow HL, Michnovicz JJ, Wong GYC, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Prevent Biomark Epidemiol 1994;3:591-5
33. Zhu BT, Conney AH. Functional role of estrogen metabolism in target cells: review and perspectives. Cardnogenesis 1998;19:1-27