Scale-up of an intermolecular barbier reaction

Organic Process Research and Development

Volumn 2, Issue 5, 1998, Pages 287-289

  Ennis, David S ^a   Lathbury, David C ^a   Wanders, Andre ^a   Watts, David ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0032382851     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op980003k     Document Type: Article

References (4)

1. Kihara, M.; Kashimoto, M.; Kobayashi, Y.; Kobayashi, S. Tetrahedron Lett. 1990, 31, 5347-5348.
2. Zhang, W.; Dowd, P. Tetrahedron Lett. 1993, 34, 2095-2098. For a review, see: Blomberg, C. The Barbier Reaction and Related One-step Process; Springer-Verlag: Berlin, 1993.
3. Zhang, W.; Dowd, P. Tetrahedron Lett. 1993, 34, 2095-2098. For a review, see: Blomberg, C. The Barbier Reaction and Related One-step Process; Springer-Verlag: Berlin, 1993.
4. Addition of n-BuLi was stopped after 50% of the required charge had been added. The reaction mixture was maintained at -65 °C. After 2 h, the remaining n-BuLi was added as normal.