Design and Synthesis of Furoxan Derivatives as Probe for the Nitric Oxide Generation

Bulletin of the Korean Chemical Society

Volumn 19, Issue 5, 1998, Pages 506-507

  Hwang, Kwang Jin ^a   Kang, Hokyoung ^a  

^a Hong Ik University   (South Korea)

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EID: 0032373029     PISSN: 02532964     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. (a) Feelisch, M.; Stamler, J. S. Eds. Methods in Nitric Oxide Research; John Wiley: England, 1996.
2. (b) Butler, A. R.; Williams, D. L. H. Chem. Soc. Rev. 1993, 22, 233.
3. (a) Moncada, S.; Palmer, R. M. J.; Higgs, E. A. Pharmacol. Rev. 1991, 43, 109.
4. (b) Palmer, R. M. J.; Ferrige, A. G.; Moncada, S. Nature 1987, 327, 524.
5. (c) Furchagott, R. F.; Zawadzki, J. V. Nature 1980, 288, 373.
6. (a) Sexton, D. J.; Muruganandam, A.; Mckenney, D. J.; Mutus, B. Photochem. Photobiol. 1994, 59, 463.
7. (b) Nathan, C. F.; Hibbs, Jr. J. B. Curr. Opin. Immunol. 1991, 3, 65.
8. (c) Marletta, M. A.; Yoon, P. S.; Lyengar, R.; Leaf, C. D.; Wishnok, J. S. Biochemistry 1988, 27, 8706.
9. (d) Hibbs, Jr. J. B.; Vavrin, Z.; Taintor, R. R. J. Immunol. 1987, 138, 550.
10. (a) Montague, P. R.; Gancayco, C. D.; Winn, M. J.; Marchase, R. B.; Friedlander, M. J. Science 1994, 263, 973.
11. (b) Snyder, S. H. Science 1992, 257, 494.
12. (a) Feelisch, M.; Schonafinger, K.; Noack, E. Biochem. Pharmacol. 1992, 44, 1149.
13. (b) Feelisch, M. J. Cardiovasc. Pharmacol. 1991, 17, S25.
14. (a) Hwang, K.-J.; Jo, I.; Shin, Y. A.; Yoo, S.; Lee, J. H. Tetrahedron Lett. 1995, 36, 3337.
15. (b) Lee, S. H.; Jo, I.; Lee, H. H.; Hwang, K.-J. Bull. Korean Chem. Soc. 1997, 18, 1115.
16. A proposed mechanism for the NO generation by the intramolecular sulfide-nitronate interaction from the thiol containing furoxan derivative. chemical equation presented.
17. Liu, K.-C.; Shelton, B. R.; Howe, R. K. J. Org. Chem. 1980, 45, 3916.
18. Paton, R. M. In Comprehensive Heterocyclic Chemistry II; Katritzky, A. R.; Rees, C. W.; Scriven, E. F. V., Ed.; Pergamon Press: Oxford, UK, 1996; Vol 4, pp 259-262.
19. 3,) δ 17.1, 19.9, 20.0, 22.5, 23.7, 61.4, 67.2, 113.0, 128.6, 131.0, 143.8, 155.1.
20. 3,) δ 17.8, 19.1, 19.2, 20.8, 22.6, 23.8, 61.3, 61.4, 113.4, 155.4, 169.3, 169.4.
21. 2S).
22. 3), δ 20.0, 20.1 21.5, 24.1, 62.7, 64.8, 111.1, 126.2, 126.4, 128.6, 128.7, 130.5, 144.1, 152.9.
23. 2S).