Modelling and decision support in physiology and medicine: A methodological framework with illustrations

Mathematical and Computer Modelling of Dynamical Systems

Volumn 4, Issue 1, 1998, Pages 73-99

  Carson, E R ^a   Hovorka, R ^a   Roudsari, A V ^a   Summers, R ^a  

^a CITY UNIVERSITY   (United Kingdom)

Author keywords

Carbohydrate metabolism; Decision support system; Diabetes; Glucose insulin model; Insulin dosage adjustments; Mathematical modelling; Model validation; Modelling methodology; System evaluation

Indexed keywords

EID: 0032368983     PISSN: 13873954     EISSN: None     Source Type: Journal    
DOI: 10.1080/13873959808837069     Document Type: Article

References (29)

1. Carson, E.R., Cobelli, C., Finkelstein, L.: Mathematical Modelling of Metabolic and Endocrine Systems. Wiley, New York, 1983.
2. Carson, E.R., Hovorka, R.: Metabolic modelling: past, present and future. F. Breiteneker, I. Husinsky (eds.): Proceedings of EUROSIM '95, Vienna, September 1995. Elsevier, Amsterdam 1995.
3. Godfrey, K.: Compartmental Models and their Applications. Academic Press, London 1983.
4. Jacquez, J.A.: Compartmental Analysis in Biology and Medicine: Kinetics of Distribution of Tracer-Labelled Materials. Elsevier, Amsterdam, 1972.
5. Carson, E.R., Flood, R.L.: Model validation: philosophy, principles and application. Trans. Inst. Meas. Contr., 12 (1990), pp. 178-185.
6. Carson, E.R., Hovorka, R., Roudsari, A. V., Summers, R.: Evaluation of knowledge-based decision support systems and model validation: methodological unity? M.K. Chytil, G. Duru, W. van Eimeren, C.D. Flagle (eds.): Proceedings of the 5th Int. Conf. on Systems Science in Health Care. Omnipress Publishing, Prague, 1992, pp. 1357-1360.
7. Wyatt, J., Spiegelhalter, D.: Evaluating medical expert systems: What to test and how? Med. Inform., 15 (1990), pp. 205-217.
8. Meadows, K.A., Fromson, B., Gillespie, C., Brewer, A., Carter, C., Lockington, T., Clark, G., Wise, P.H.: Development, validation and application of computer-linked knowledge questionnaires in diabetes education. Diabetic Medicine, 5 (1988), pp. 61-67.
9. Engelbrecht, R., Moser, W., Schneider, J., Rector, A.L.: Evaluation of knowledge-based systems: the EURODIABETA framework. Diabetes, Nutrition and Metabolism, 4 (suppl.) (1991), pp. 209-212.
10. Friedman, C.P., Wyatt, J.: Evaluation Methods in Medical Informatics. Springer, New York, 1997.
11. Summers, R., Carson, E.R.: Evaluation of intelligent decision aids for application in critical care medicine. J.H. Nagel, W.M. Smith (eds.): Proceedings of the 13th Annual. Int. Conf. IEEE Eng. Med. Biol. Soc. IEEE, New York, 1991, pp. 1310-1311.
12. Hovorka, R., Cavan, D.A., Jones, R.H., De La Paz, H., Rees, S.E., Shojaee-Moradie, F., Umpleby, A.M.: Decomposition of two compartment model of glucose kinetics using 3-0-methyl-glucose, P. Kneppo, M. Tysler (eds.): Model Based Biomeasurements, Proceedings of the 7th International IMEKO TC-13 Conference on Measurements in Clinical Medicine. Slovak Academy of Sciences, Bratislava, 1995, pp. 15-17.
13. Wolfe, R.R.: Radioactive and Stable Isotope Tracers in Biomedicine. Wiley-Liss, New York, 1992.
14. Mari, A.: Estimation of the rate of appearance in the non-steady state with a two-compartment model. Am. J Physiol., 263 (1992), pp. E400-E415.
15. Cobelli, C., Toffolo, G., Foster, D.M.: Tracer-to-tracee ratio for analysis of stable isotope tracer data: link with radioactive kinetic formalism, Am. J. Physiol., 262 (1992), pp. E968-E975.
16. Foster, D.M., Barrett, P.H.R., Bell, B.M., Beltz, W.F., Cobelli, C., Golde, H., Jacquez, J.A., Phair, R.D.: SAAM II: simulation, analysis and modelling software. BMES Bulletin, 118(2) (1994), pp. 19-21.
17. Ganong, W.F.: Review of Medical Physiology. Appleton & Lange, Norwalk, 1989.
18. Carson, E.R., Deutsch, T.: A spectrum of approaches for controlling diabetes. IEEE Control Systems 12(6) (1992), pp. 25-31.
19. Hovorka, R., Carson, E.R. (eds.): Computers in Diabetes. Comput. Meth. Prog. Biomed. 41(1994), pp. 151-308.
20. Carson, E.R., Hovorka, R., Andreassen, S. (eds.): Computers in Diabetes. Comput. Meth. Prog. Biomed. 50 (1996), pp. 207-278.
21. Albisser, A.M., Schiffrin, A., Schutz, M., Tiran, J., Leibel, B.S.: Insulin dosage adjustment using manual methods and computer algorithms: a comparative study. Med. Biol. Eng. Comput. 24(1986), pp. 577-584.
22. Salzsieder, E., Albrecht, G., Fischer, U., Rutscher, A., Thierback, U.: Computer- aided systems in the management of type I diabetes: the application of a model-based strategy. Comput. Meth. Prog. Biomed. 32 (1990), pp. 215-224.
23. Andreassen, S., Benn, J.J., Hovorka, R., Olesen, K.G., Carson, E.R.: A probabilistic approach to glucose prediction and insulin dose adjustment: description of metabolic model and pilot evaluation study. Comput. Meth. Prog. Biomed. 41(1994), pp. 153-166.
24. Lehmann, E.D., Deutsch, T., Roudsari, A.V., Carson, E.R., Benn, J.J., Sönksen, P.H.: An integrated approach for the computer-assisted treatment of diabetic patients on insulin. Med. Inform. 17(1992), pp. 105-123.
25. Deutsch, T., Roudsari, A.V., Leicester, H.J, Theodorou, T., Carson, E.R.: UTOPIA: a consultation system for visit-by-visit diabetes management. Med. Inform. 21(1996).
26. Harvey, A.C.: Forecasting, Structural Time Series Models and the Kaiman Filter. Cambridge University Press, Cambridge, 1989.
27. Roudsari, A.V., Leicester, H.J., Lehmann, E.D., Hovorka, R., Andreassen, S., Deutsch, T., Carson, E.R., Sönksen, P.H.: A validation methodology for testing decision support systems for insulin dosage adjustment, K.-P. Adlassnig, G. Grabner, S. Bengtsson, R. Hansen (eds.): Lecture Notes in Medical Informatics, volume 45. Springer-Verlag, Berlin 1991, pp. 382-388.
28. Roudsari, A.V., Leicester, H.J., Lawrence, P.A., Hovorka, R., Lehmann, E.D., Carson, E.R., Sönksen, P.H.: A practical application of a retrospective validation methodology, M.K. Chytil, G. Duru, W. van Eimeren, C.D. Flagle (eds.): Proceedings of the 5th Int. Conf. on Systems Science in Health Care. Omnipress Publishing, Prague, 1992, pp. 1296-1299.
29. Leicester, H.J., Roudsari, A.V., Lehmann, E.D., Carson, E.R.: Methodological issues in validating decision support systems for insulin dosage adjustment. Artif. Intell. Med. 6 (1994), pp. 161-174.