A scalable synthesis of the thromboxane receptor antagonist 3-{3-[2-(4-chlorobenzenesulfonamido)ethyl]-5-(4-fluorobenzyl)phenyl}propionic acid via a regioselective heck cross-coupling strategy

Organic Process Research and Development

Volumn 2, Issue 2, 1998, Pages 116-120

  Waite, D C ^a   Mason, C P ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0032366684     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op970060y     Document Type: Article

References (6)

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2. Dack, K. N.; Dickinson, R. P.; Long, C. J.; Steele, J. Bioorg. Med. Chem. Lett., in press.
3. Bretherick, L. Chem. Ind. 1971, 1017.
4. (a) Tao, W.; Nesbitt, S.; Heck, R. F. J. Org. Chem. 1990, 55, 63
5. (b) Plevyak, J. E.; Dickerson, J. E.; Heck, R. F. J. Org. Chem. 1979, 44, 4078.
6. Johnson, P. Y; Wen, J. Q. J. Org. Chem. 1981, 46, 2767.