Synthesis and diuretic activity of 4,5-dihydro-6H-imidazo[4,5,1- ij]quinoline-6-one 6-oxime-O-sulfonic acid derivatives

European Journal of Medicinal Chemistry

Volumn 33, Issue 10, 1998, Pages 763-774

  Nishijima, Kazumi ^a   Shinkawa, Tomoaki ^a   Ito, Manabu ^a   Nishida, Hidemitsu ^a   Yamamoto, Ichirou ^a   Onuki, Yoshiaki ^a   Inaba, Hitoshi ^a   Miyano, Soutarou ^b  

^a MOCHIDA PHARMACEUTICAL CO   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Computation chemistry; Diuretic activity; Imidazo 4,5,1 ij quinoline 6 one 6 oxime O sulfonic acid; M17055; Structure activity relationship

Indexed keywords

4,5 DIHYDRO IMIDAZOL[4,5,1]QUINOLINE 6 ONE 6 OXIME SULFONIC ACID; 7 CHLORO 2,3 DIHYDRO 1 (2 METHYLBENZOYL) 4(1H) QUINOLINONE 4 OXIME O SULFONIC ACID POTASSIUM; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; DIURESIS; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

EID: 0032318574     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)80028-2     Document Type: Article

References (15)

1. [1] Nishijima K., Shinkawa T., Kato K., Sato N., Nishida H., Yamashita Y., Onuki Y., Mizota M., Ohtomo K., Miyano S., Eur. J. Med. Chem. 33 (1998) 267-277.
2. [2] Cragoe E.J. (Ed.), Chemistry and Pharmacology of Drugs, Vol. 2: Diuretics - Chemistry, Pharmacology and Medicine, Wiley, New York, 1983.
3. [3] Puschett J.B., Greenberg A. (Ed.), Diuretics: Chemistry, Pharmacology and Clinical Applications, Elsevier, New York, 1984.
4. [4] Shinkawa T., Yamasaki F., Kikuchi A., Nakakuki M., Nishijima K., Uemura A., Mizota M., Orita Y., Arzneim. Forsch. Drug Res. 42 (1992) 1466-1472.
5. [5] Shinkawa T., Yamasaki F., Notsu T., Nakakuki M., Nishijima K., Yoshitomi K., Imai M., Eur. J. Pharmacol. 238 (1993) 317-325.
6. [6] Yamasaki F., Yoshitomi K., Shinkawa T., Imai M., J. Pharmacol. Exp. Ther. 266 (1993) 1581-1588.
7. [7] Yasoshima K., Yamasaki F., Shinkawa T., Yoshitomi K., Imai M., J. Pharmacol. Exp. Ther. 266 (1993) 1589-1593.
8. [8]Kamenka J.M., Alam M.N., J. Heterocycl. Chem. 10 (1973) 459-462.
9. [9] Chothia D.S., Dike S.Y., Engineer A.B., Merchant J.R., Indian J. Chem. 14B (1976) 323-325.
10. [10] Geneste P., Kamenka J.M., Vidal Y., Fauquet J.P., Morel E., Muller P., Warolin C., Eur. J. Med. Chem. Chim. Ther. 13 (1978) 53-59.
11. [11] Geneste P., Kamenka J.M., Vidal Y., Besancon M., Garcet S., Muller P., Warolin C., Eur. J. Med. Chem. Chim. Ther. 12 (1977) 471-476.
12. [12] Merchant J.R., Shankamarayan V., Curr. Sci. 48 (1979) 585-586.
13. [13] Papadopoulos E.P., George B., J. Org. Chem. 42 (1977) 2530-2532.
14. [14] Ozaki K., Yamada Y., Oine T., Chem. Pharm. Bull. 31 (1983) 2234-2243.
15. [15] Ishihara Y., Kiyota Y., Goto G., Chem. Pharm. Bull. 38 (1990) 3024-3030.