Synthesis of new cotelomers derived from tris(hydroxymethyl) aminomethane bearing arabinofuranosylcytosine moieties. Preliminary results on their in vitro and in vivo antitumoral activities

European Journal of Medicinal Chemistry

Volumn 33, Issue 10, 1998, Pages 809-816

  Contino, Christiane ^a   Maurizis, Jean Claude ^b   Ollier, Monique ^b   Rapp, Maryse ^b   Lacombe, Jean Michel ^a   Pucci, Bernard ^a  

^a UNIVERSITY OF AVIGNON   (France)

^b INSERM   (France)

Author keywords

Antitumoral activity; Arabinofuranosylcytosine; Prodrugs; Telomers; Tris

Indexed keywords

CYTARABINE DERIVATIVE; FLUCYTOSINE ARABINOSIDE; TROMETAMOL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DNA SYNTHESIS INHIBITION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG SYNTHESIS; ENZYME ACTIVATION; PROTON NUCLEAR MAGNETIC RESONANCE; TELOMERE;

EID: 0032311169     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(99)80032-4     Document Type: Article

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