Flavonol glycosides from Croton menthodorus reduce in vitro morphine withdrawal

Pharmaceutical Biology

Volumn 36, Issue 5, 1998, Pages 310-314

  Capasso, Anna ^a   Piacente, Sonia ^a   Cumandà, Jativa ^a   De Tommasi, Nunziatina ^a   Ragucci, Massimo ^a   Pizza, Cosimo ^a  

^a UNIVERSITY OF SALERNO   (Italy)

Author keywords

Croton menthodorus; Flavonol glycosides; Guinea pig ileum; Morphine withdrawal in vitro

Indexed keywords

ACETYLCHOLINE; CROTON EXTRACT; FLAVONOL DERIVATIVE; KAEMPFEROL 3 O (6 O 4 COUMAROYL) BETA DEXTRO GLUCOPYRANOSIDE; KAEMPFEROL DERIVATIVE; NICOTIFLORIN; PLANT GLYCOSIDE; QUERCETIN 3 O (2 O BETA APIOFURANOSYL)RUTINOSIDE; RUTOSIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG WITHDRAWAL; ELECTROSTIMULATION; GUINEA PIG; MALE; NONHUMAN; WITHDRAWAL SYNDROME;

EID: 0032311163     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1076/phbi.36.5.310.4650     Document Type: Article

References (20)

1. Bors W, Heller W, Michel C, Saran, M (1990): Flavonoids as antioxidant: Determination of radical-scavenging efficiencies. Meth Enzymol 186: 343-355.
2. Capasso A, Pinto A, Mascolo N, Autore G, Capasso F (1991a): Reduction of agonist-induced contractions of guinea-pig isolated ileum by flavonoids. Phytother Res 5: 85-88.
3. Capasso A, Pinto A, Sorrentino R, Capasso F (1991b): Inhibitory effects of quercetin and other flavonoids on electrically-induced contractions of guinea pig isolated ileum. J Ethnopharmacol 34: 279-281.
4. Capasso A, Di Giannuario A, Loizzo A, Sagratella S, Pieretti S, Sorrentino L (1996): Dexamethasone-induced selective inhibition of opioid physical dependence in isolated tissues. J Pharmacol Exp Ther 276: 743-751.
5. Capasso A, Sorrentino L (1997): Arachidonic acid cascade is involved in the expression of morphine dependence in vitro. Eur J Pharmacol 330: 199-204.
6. Capasso A, Piacente S, Pizza C, Sorrentino L (1998): Flavonoids reduce morphine withdrawal in vitro. J Pharm Pharmacol 50: 561-564.
7. Chal LA (1983): Contraction of guinea-pig ileum on withdrawal of methionine 3-enkephalin is mediated by substance P. Br J Pharmacol 80: 741-749.
8. Ferriola PC, Cody V, Middleton E, Jr (1989): Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationship. Biochem Pharmacol 38: 1617-1624.
9. Galvéz J, De La Cruz JP, Zarzuelo A, Sánchez de Medina F Jr, Jenenez J, Sánchez de la Cuesta F (1994): Gen Pharmacol 25: 1237-1243.
10. Laughton MJ, Evans PJ, Moroney MA, Hoult JRS, Halliwell B (1991): Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additive. Relationship to antioxidant activity and to iron-reducing ability. Biochem Pharmacol 42: 1673-1681.
11. Lee TP, Mattelliano ML, Middleton E (1982): Effect of quercetin on human polymorphonuclear leukocyte lysosomal enzyme release and phospholipid metabolism. Life Sci 31:2765-2774.
12. Marini Bettolo R, Scarpati ML (1979): Alkaloids of Croton draconoides. Phytochemistry 18: 520-525.
13. Martin WR, Eades CG (1967): Pharmacological studies of spinal cord adrenergic and cholinergic mechanism and their relation to physical dependence on morphine. Psychopharmacologia 11: 195-223.
14. Middleton E, Kandaswami C (1992): Plant flavonoid modulation of immune and inflammatory cell function. Biochem Pharmacol 43: 1167-1179.
15. Nakayama T, Yamada M, Osawa T, Kawakishi S (1993): Suppression of active oxygen-induced cytotoxicity by flavonoids. Biochem Pharmacol 45: 265-267.
16. Nishioka H, Imoto M, Sawa T, Namada M, Naganawa H, Takeuchi T, Umezawa K (1989): Screening of phosphatidylinositol kinase inhibitors from Streptomyces. J Antibiot 42: 823-825.
17. Piacente S, Capasso A, Cumandà J, De Tommasi N, Ragucci M, Sorrentino L, Pizza C (1997): Constituents of Croton menthodorus and their effects on electrically-induced contractions of isolated guinea-pig ileum. Int J Pharmacog (In Press).
18. Tsou K, Lovie G, Way EL (1982): Manifestation of gut opiate withdrawal contraction and its blocade by capsaicina. Eur J Pharmacol 81: 377-383.
19. Valeri P, Martinelli B, Morrone LA, Severini C (1990): Reproducible withdrawal contractions of isolated guinea-pig ileum after morphine exposure: effects of clonidine and nifedipine. J Pharm Pharmacol 42: 115-120.
20. Welton AF, Hurley J, Will P (1988): Flavonoids and arachidonic acid metabolism. In Plant Flavonoids in Biology and Medicine II: Biochemical, Cellular and Medicinal Properties, ed. by V Cody, E Middleton Jr, JB Harborne, A Beretz, pp. 301-312, Alan R Liss, Inc, New York.