Enhanced electron transfer from glucose oxidase to DNA-immobilized electrode aided by ferrocenyl naphthalene diimide, a threading intercalator

Chemistry Letters

Volumn , Issue 10, 1998, Pages 989-990

  Takenaka, Shigeori ^a   Uto, Yoshihiro ^a   Takagi, Makoto ^a   Kondo, Hiroki ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0032278192     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.1998.989     Document Type: Article

References (7)

1. S. Takenaka, Y. Uto, H. Saita, M. Yokoyama, H. Kondo, and W. D. Wilson, J. Chem. Soc., Chem. Commun., 1111 (1998).
2. W. D. Wilson and F. A. Tanious, in Molecular Aspects of Anticancer Drug-DNA Interactions, ed by S. Neidle and M. J. Waring, Macmillan Press, Riverside, NJ (1994), p. 243.
3. J. D. McGhee and P. H. von Hippel, J. Mol. Biol., 86, 469 (1974).
4. J. G. Voet, J. Coe, J. Epstein, V. Matossian, and T. Shipley, Biochemistry, 20, 7182 (1981).
5. The CV wave for 2 is reversible, while that of 1 is not as is inferred by its reduced cathodic CV peak. However, the reproducibility is quite good. The CV behavior of the ferrocene part of 1 is also connected to the behavior of the naphthalene diimide part of 1, the details of which is to be published elsewhere.
6. 5, and the comparison with the modified electrode did not give much information. However, the Imax values were nearly the same for the two electrode in the same GOx-glucose sample solution, typically 2.4 μA for bare Au electrode and 2.8 μA for modified electrode. This indicates that 1 did not reduce its mediating ability even though it is complexed to DNA and thus ankered to the electorde suface. This is contarary to ordinary observations that the mediators reduce its ability when they are chemically firmly ankered on the electrode.
7. E. Braun, Y. Eichen, U. Sivan, and G. Ben-Yoseph, Nature, 391, 775 (1998).