Synthesis of praziquantel derivatives and their in vitro activity against adult Clonorchis sinensis

Archives of Pharmacal Research

Volumn 21, Issue 6, 1998, Pages 744-748

  Kim, Choong Sup ^a   Min, Duk Young ^b  

^a Korea Institute of Science and Technology   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Anthelmintic activity; Clonorchis sinensis; Praziquantel derivatives

Indexed keywords

ANTHELMINTIC AGENT; DRUG DERIVATIVE; PRAZIQUANTEL;

ANIMAL; ARTICLE; CLONORCHIS SINENSIS; DOSE RESPONSE; DRUG EFFECT; PARASITOLOGY; RABBIT; SYNTHESIS;

ANIMALS; ANTHELMINTICS; CLONORCHIS SINENSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; PRAZIQUANTEL; RABBITS;

EID: 0032254493     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02976769     Document Type: Article

References (10)

1. Abo-Ghalia, M. H. and Soliman A. E-M., Synthesis and antischistosomal activity of a new 2-nicotinoyl dipeptide analog of praziquantel. Arzneim.-Forsch., 46, 207-209 (1996).
2. Day, T. A., Bennett, J. L. and Pax, R. L., Praziquantel: the enigmatic antiparasitic. Parasitol. Today, 8, 342-344 (1992).
3. Frehel, D. and Maffrand, J-P., New syntheses of Praziquantel: 2-(cyclohexylcabonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4- one. Heterocycles, 20, 1731-1735 (1983).
4. Hardman, J, G., Limbard, L. E., Molinoff, P. B., Ruddon, R. W. and Gilman, A. G., Goodman & Gilman's The Phamarcological Basis of Therapeutics, Intl. Ed., McGraw-Hill, New York, pp 1020-1022, (1996).
5. Hassanein, H., El Nahal, H. M. and Gerges, F. R., Synthesis of some non-antimonia compounds bioisosteric to praziquantel. Eur. J. Med. Chem. 30, 525-529 (1995).
6. Kim, C. H., Kim, J. H., Park, H. K. and Lee, Y. S., Formation of pyrazinoisoquinoline ring system by the tandem amidoalkylation and N-acylimminium ion cyclization : an efficient synthesis of praziquantel. Tetrahedron, 54, 7395-7400 (1998).
7. Pholke, R., Loebich, F., Seubert, J., Thomas, H. and Andrew, P., Pyrazinoisoquinoline anthelmintics. Ger. Offen. 2,331,713 (1975).
8. Rim, H. J., Jo, S. W., Joo, K. H. and Kim, S. S. In vitro activities of various drugs against adult worms of Clonorchis sinensis. Korean J. of Parasitol. 18, 185-191 (1980).
9. Seubert, J., Pohlke, R. and Loebich, F., Synthesis and properties of praziquantel, a novel broad spectrum anthelmintic with excellent activity against Schistosomes and Cestodes. Experientia, 33, 1036 (1977).
10. Yuste, F., Pallas, Y., Barrios, H., Ortiz, B. and Sanchez-Obregon, R., A short synthesis of praziquantel. J. Heterocycl. Chem., 23, 189 (1986).