Destruction of Serotonergic Neurons in the Median Raphe Nucleus Blocks Circadian Rhythm Phase Shifts to Triazolam but Not to Novel Wheel Access

Journal of Biological Rhythms

Volumn 13, Issue 6, 1998, Pages 494-505

  Meyer Bernstein, Elizabeth L ^a,b   Morin, Lawrence P ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

5,7 dihydroxytryptamine; Circadian; Neurotoxin; Novel wheel; Phase response; Raphe; Serotonin; Wheel running

Indexed keywords

ANIMALIA; CRICETINAE;

5,7 DIHYDROXYTRYPTAMINE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; SEROTONIN; SEROTONIN RECEPTOR AFFECTING AGENT; TRIAZOLAM;

ANIMAL; ARTICLE; CELL COUNT; CIRCADIAN RHYTHM; CYTOLOGY; DENSITOMETRY; DRUG EFFECT; HAMSTER; IMMUNOHISTOCHEMISTRY; MALE; MOTOR ACTIVITY; NERVE CELL; PHYSIOLOGY; RAPHE NUCLEUS; SYRIAN HAMSTER;

5,7-DIHYDROXYTRYPTAMINE; ANIMALS; CELL COUNT; CIRCADIAN RHYTHM; CRICETINAE; DENSITOMETRY; GABA MODULATORS; IMMUNOHISTOCHEMISTRY; MALE; MESOCRICETUS; MOTOR ACTIVITY; NEURONS; RAPHE NUCLEI; SEROTONIN; SEROTONIN AGENTS; TRIAZOLAM;

EID: 0032253631     PISSN: 07487304     EISSN: None     Source Type: Journal    
DOI: 10.1177/074873098129000327     Document Type: Article

References (59)

1. Albers HE and Ferris CF (1984) Neuropeptide Y: Role in light-dark entrainment of hamster circadian rhythms. Neurosci Lett 50:163-168.
2. Albers HE Ferris CF, Leeman SE, and Goldman BD (1984) Avian pancreatic polypeptide phase shifts hamster arcadian rhythms when microinjected into the suprachiasmatic region. Science 223:833-835.
3. Antle MC, Marchant EG, Chubaty P, McHattie L, Neil L, and Mistlberger RE (1997) Serotonin antagonists and agonists fail to modulate activity-induced phase shifts of circadian rhythms. Soc Neurosci Abstr 23:240.
4. Biello SM, Harrington ME, and Mason R (1991) Geniculohypothalamic tract lesions block chlordiazepoxide-induced phase advances in Syrian hamsters. Brain Res 552:47-52.
5. Biello SM, Janik D, and Mrosovsky N (1994) Neuropeptide Y and behaviorally induced phase shifts. Neuroscience 62:273-279.
6. Biello SM and Mrosovsky N (1993) Circadian phase-shifts induced by chlordiazepoxide without increased locomotor activity. Brain Res 622:58-62.
7. Bobrzynska, K (1996) Serotonergic and behavioral influences on circadian rhythmicity in hamster. Unpublished manuscript, University of Toronto.
8. Bobrzynska K, Vrang N, and Mrosovsky N (1996) Persistence of nonphotic phase shifts in hamsters after serotonin depletion in the suprachiasmatic nucleus. Brain Res 741:205-214.
9. Bosler O, Vuillon-Cacciuttolo G, and Saidi H (1992) Long-term serotonin reinnervation of the suprachiasmatic nucleus after 5,7-dihydroxytryptamine axotomy m the adult rat. Neurosci Lett 143:159-163.
10. Cutrera RA, Kalsbeek A, and Pevet P (1994) Specific destruction of the serotonergic afferents to the suprachiasmatic nuclei prevents triazolam-induced phase advances of hamster activity rhythms. Behav Brain Res 62:21-28.
11. DiNardo LA, Dudley TE, and Glass JD (1998) Pharmacological and electrical manipulations of median and dorsal raphe activity: Effects on 5-HT release in hamster SCN. Soc Res Biol Rhythms 6:79.
12. Dudley TE and Glass JD (1997) Circadian differences in wheel-running-induced 5-HT release in the suprachiasmatic nucleus. Soc Neurosci Abstr 23:240.
13. Edgar DM, Miller JD, Prosser RA, Dean RR, and Dement WC (1993) Serotonin and the mammalian circadian system. II. Phase-shifting rat behavioral rhythms with serotonergic agonists. J Biol Rhythms 8:17-31.
14. Edgar DM, Reid MS, and Dement WC (1997) Serotonergic afferents mediate activity-dependent entrainment of the mouse circadian clock. Am J Physiol 273:R265-R269.
15. Harrington ME, Nance DM, and Rusak B (1985) Neuropeptide Y immunoreactivity in the hamster geniculosuprachiasmatic tract. Brain Res Bull 15:465-472.
16. Harrington ME and Rusak B (1989) Photic responses of geniculohypothalamic tract neurons in the Syrian hamster. Vis Neurosci 2:367-375.
17. Huhman KL, Babagbemi TO, and Albers HE (1995) Bicucculine blocks neuropeptide Y-induced phase advances when microinjected in the suprachiasmatic nucleus of Syrian hamsters. Brain Res 675:333-336.
18. Janik D, Mikkelsen JD, and Mrosovsky N (1995) Cellular colocalization of Fos and neuropeptide Y in the intergeniculate leaflet after nonphotic phase-shifting events. Brain Res 698:137-145.
19. Janik D and Mrosovsky N (1992) Gene expression in the geniculate induced by a nonphotic circadian phase shifting stimulus. Neuroreport 3:575-578.
20. Janik D and Mrosovsky N (1993) Nonphotically induced phase shifts of circadian rhythms in the golden hamster: Activity-response curves at different ambient temperatures. Physiol Behav 53:431-436.
21. Janik D and Mrosovsky N (1994) Intergeniculate leaflet lesions and behaviorally induced shifts of circadian rhythms. Brain Res 651:174-182.
22. Johnson RF, Moore RY, and Morin LP (1989) Lateral geniculate lesions alter activity rhythms in the hamster. Brain Res Bull 22:411-422.
23. Johnson RF, Smale L, Moore RY, and Morin LP (1988) Lateral geniculate lesions block circadian phase shift responses to a benzodiazepine. Proc Natl Acad Sci USA 85:5301-5304.
24. Marchant EG, Watson NV, and Mistlberger RE (1997) Both neuropeptide Y and serotonin are necessary for entrainment of circadian rhythms in mice by daily treadmill running schedules. J Neurosci 17:7974-7987.
25. Maywood ES, Smith E, Hall SJ, and Hastings MH (1997) A thalamic contribution to arousal-induced, non-photic entrainment of the circadian clock of the Syrian hamster. Eur J Neurosci 9:1739-1747.
26. Medanic M and Gillette MU (1992) Serotonin regulates the phase of the rat suprachiasmatic circadian pacemaker in vitro only during the subjective day. Eur J Physiol 450:629-642.
27. Meyer EL, Harrington ME, and Rahmani T (1993) A phase-response curve to the benzodiazepine chlordiazepoxide and the effect of geniculo-hypothalamic tract ablation. Physiol Behav 53:237-243.
28. Meyer-Bernstein E (1998) Functional neuroanatomy of the circadian timing system. PhD dissertation, State University of New York at Stony Brook.
29. Meyer-Bernstein EL and Morin LP (1996) Differential serotonergic innervation of the suprachiasmatic nucleus and the intergeniculate leaflet and its role in circadian rhythm modulation. J Neurosci 16:2097-2111.
30. Meyer-Bernstein EL and Morin LP (1997) The serotonergic projection from the median raphe nucleus to the suprachiasmatic nucleus modulates activity phase onset but not other circadian rhythm parameters. Brain Res 755:112-120.
31. A/benzodiazepine receptor localization in the circadian timing system. Brain Res 531:16-24.
32. Mintz EM, Gillespie CF, Marvel CL, Huhman KL, and Albers HE (1997) Serotonergic regulation of circadian rhythms in Syrian hamsters. Neuroscience 79:563-569.
33. Mistlberger RE, Houpt TA, and Moore-Ede MC (1991) The benzodiazepine triazolam phase-shifts circadian activity rhythms in a diurnal primate, the squirrel monkey (Saimiri sciureus). Neurosci Lett 124:27-30.
34. Morin LP (1991) Neural control of circadian rhythms as revealed through the use of benzodiazepines. In Suprachiasmatic Nucleus: The Mind's Clock, DC Klein, RY Moore, and SM Reppert, eds, pp 324-338, Oxford University Press, New York.
35. Morin LP (1992) Serotonergic reinnervation of the hamster suprachiasmatic nucleus and intergeniculate leaflet without functional circadian rhythm recovery. Brain Res 599:98-104.
36. Morin LP, Blanchard JH, and Moore RY (1992) Intergeniculate leaflet and suprachiasmatic nucleus organization and connections in the hamster. Vis Neurosci 8:219-230.
37. Mrosovsky N (1996) Locomotor activity and non-photic influences on circadian clocks. Biol Rev Cambr Phil Soc 71:343-372.
38. O'Hearn E, Battaglia G, DeSouza EB, Kuhar MJ, and Mollier ME (1988) Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: Immunocytochemical evidence for neurotoxicity. J Neurosci 8:2788-2803.
39. Penev PD, Turek FW, and Zee PC (1995) A serotonin neurotoxin attenuates the phase-shifting effects of triazolam on the circadian clock in hamsters. Brain Res 669:207-216.
40. Penev PD, Zee P, and Turek FW (1994) Monamine depletion blocks triazolam-induced phase advances of the circadian clock in hamsters. Brain Res 637:255-261.
41. Prosser RA, Dean RR, Edgar DM, Heller HC, and Miller JD (1993) Serotonin and the mammalian circadian system. I. In vitro phase shifts by serotonergic agonists and antagonists. J Biol Rhythms 8:1-16.
42. 2+. Brain Res 573:336-340.
43. + channel opening. Brain Res 644:67-73.
44. Prosser RA, Miller JD, and Heller HC (1990) A serotonin agonist phase shifts the circadian clock in the suprachiasmatic nuclei in vitro. Brain Res 534:336-339.
45. B receptors. J Neurosci 9:2858-2865.
46. Ralph MR and Mrosovsky N (1992) Behavioral inhibition of circadian responses to light. J Biol Rhythms 7:353-359.
47. Reebs SG and Mrosovsky N (1989) Effects of induced wheel running on the circadian activity rhythms of Syrian hamsters: Entrainment and PRC. J Biol Rhythms 4:39-48.
48. Rusak B, Meijer JH, and Harrington ME (1989) Hamster circadian rhythms are phase-shifted by electrical stimulation of the geniculo-hypothalamic tract. Brain Res 493:283-291.
49. Smale L, Michels KM, Moore RY, and Morin LP (1990) Destruction of the hamster serotonergic system by 5,7-DHT: Effects on circadian rhythm phase, entrainment and response to triazolam. Brain Res 515:9-19.
50. Smith RD, Turek FW, and Takahashi JS (1992) Two families of phase-response curves characterize the resetting of the hamster circadian clock. Am J Physiol 262:R1149-R1153.
51. Sumova A, Maywood ES, Selvage D, Ebling FJP, and Hastings MH (1996) Serotonergic antagonists impair arousal-induced phase shifts of the circadian system of the Syrian hamster. Brain Res 709:88-96.
52. 1A receptor agonists on the circadian rhythm of wheel-running activity in hamsters. Eur J Pharmacol 214:79-84.
53. Turek FW (1989) Effects of stimulated physical activity on the circadian pacemaker of vertebrates. J Biol Rhythms 4:135-147.
54. Turek FW and Losee-Olson S (1987) Entrainment of the circadian activity rhythm to the light-dark cycle can be altered by a short-acting benzodiazepine, triazolam. J Biol Rhythms 2:249-260.
55. Van Reeth O and Turek FW (1989) Stimulated activity mediates phase shifts in the hamster circadian clock induced by dark pulses or benzodiazepines. Nature 339:49-51.
56. Weisgerber D, Redlin U, and Mrosovsky N (1997) Lengthening of circadian period in hamsters by novelty-induced wheel running. Physiol Behav 62:759-765.
57. Wickland CR and Turek FW (1991) Phase-shifting effects of acute increases in activity on circadian locomotor rhythms in hamsters. Am J Physiol 261:R1109-R1117.
58. Wickland CR and Turek FW (1994) Lesions of the thalamic intergeniculate leaflet block activity-induced phase shifts in the circadian activity rhythm of the golden hamster. Brain Res 660:293-300.
59. Zhang Y, Van Reeth O, Zee P, Takahashi JS, and Turek FW (1993) Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam. Neurosci Lett 164:203-208.