Overexpression of Rb and E2F-1 in ataxia-telangiectasia lymphocytes

Archives of Pharmacal Research

Volumn 21, Issue 6, 1998, Pages 640-644

  Varghese, Susan ^a   Jung, Mira ^a,b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Division of Radiation Research   (United States)

Author keywords

Ataxia telangiectasia cells; E2F 1; G1 S checkpoint; Iionizing radiation; Rb

Indexed keywords

DNA BINDING PROTEIN; PHOSPHOTRANSFERASE; RETINOBLASTOMA PROTEIN; VIRUS PROTEIN;

ARTICLE; ATAXIA TELANGIECTASIA; BIOSYNTHESIS; CELL LINE; HUMAN; LYMPHOCYTE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; RADIATION EXPOSURE; SERODIAGNOSIS; UPREGULATION; WESTERN BLOTTING;

ADENOVIRUS E2 PROTEINS; ATAXIA TELANGIECTASIA; BLOTTING, WESTERN; CELL LINE; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; LYMPHOCYTES; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PRECIPITIN TESTS; RETINOBLASTOMA PROTEIN; UP-REGULATION;

EID: 0032248295     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02976750     Document Type: Article

References (23)

1. Beamish, H., Khanna, K. K. and Lavin, M. F., Ionizing radiation and cell cycle progression in AT. Radiation Res. 138, 130-133 (1994).
2. Beamish, H., Williams, R., Chen, P. and Lavin, M. F., Defect in multiple cell cycle checkpoints in AT postirradiation. J. Biol. Chem. 271, 20486-20493 (1996).
3. Chellappan, S. P., Hiebert, S., Mudryj, M., Horowitz, J. M. and Nevins, J. R., The E2F transcription factor is a cellular target for the Rb protein. Cell 65, 1053-1061 (1991).
4. De Gregori, J., Leone, G. and Ohtani, K. et al., E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent activity. Genes Dev. 9, 2873-2887 (1995).
5. Dignam, J. D., Lebowitz, R. M. and Roeder, R. G., Accurate transcription initiaton by RNA polymerase II in a soluble extract isolated from mammalian cells. Nucl. Acid Res., 11, 1475-1489 (1993).
6. Kastan, M. B., Zhan, Q. and El-Deiry, W. S. et al., A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in AT. Cell 71, 587-597 (1992).
7. Khanna, K. K. and Lavin, M. F., Ionizing radiation and UV induction of p53 protein by different pathways in AT cells. Oncogene 8, 3307-3312 (1993).
8. Khanna, K. K., Beamish, H. and Yan, J. et al., Nature of G1/S cell cycle checkpoint defect in AT. Oncogene 11, 609-618 (1995).
9. Kowalik, T. F., De Gregori, J., Schwarz, J. K. and Nevins, J. R., E2F-1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol. 69, 2491-2500 (1995).
10. La Thangue, N. B., DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell cycle control. Trends Biochem Sci. 19, 108-114 (1994).
11. Lu, X. and Lane, D. P., Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell 75, 765-778 (1993).
12. Ludlow, J. W., Glenedening, C. L., Livingston, D. M. and De Caprio, J. A., Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol. Cell. Biol. 13, 367-372 (1993).
13. Lukas, J., Peterson, B. O., Holm, K., Bartek, J. and Helin, K., Deregulated expression of E2F family members induces S-phase entry and overcomes p 16ink4A-mediated growth suppression. Mol. Cell. Biol. 16, 1047-1057 (1996).
14. McKinnon, P. J., AT: an inherited disorder of ionizing radiation sensitivity in man. Human Genet. 75, 197-208 (1987).
15. Meyn, S. M., AT and cellular responses to DNA damage. Cancer Res 55, 5991-6001 (1995).
16. Nevins, J. R., E2F: a link between the Rb tumor suppressor protein and viral oncoprotein. Science 258, 424-429 (1992).
17. Pardee, A., A restriction point for control of normal cell proliferation. Proc. Natl. Acad. Sci. USA. 71, 1286-1290 (1974).
18. Pardee, A. B., G1 events and regulation of cell proliferation. Science 246, 603-608 (1989).
19. Savitsky, K., Bar-Shira, A., Gilad, S., et al., A single AT gene with a product similar to PI-3 kinase. Science 268, 1749-1753 (1995).
20. Savitsky, K., Sfez, S., Tagle, D. A., et al., The complete coding sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Human Mol. Genet. 4, 2025-2032 (1995).
21. Shan, B., Chang, C. Y., Jones, D. and Lee, W. H., The transcription factor E2F-1 mediates the autoregulation of Rb gene expression. Mol. Cell. Biol. 14, 299-309 (1994).
22. Taylor, A. M. R., Byrd, P. J., McConville, C. M. and Thacker, S., Genetic and cellular features of AT. Int. J. Rad. Biol. 65, 6570 (1994).
23. Zakian, V. A., ATM-related genes: what do they tell us about functions of the human gene? Cell 82, 685-687 (1995).