Mechanism from isotope effects

Isotopes in Environmental and Health Studies

Volumn 34, Issue 1-2, 1998, Pages 3-17

  Cook, P F ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

Carbon 13; Carbon 14; Competitive method; Dehydrogenases; Deuterium; Isotope effects; Malic enzyme; Nitrogen 15; Noncompetitive method; Tritium

Indexed keywords

ALCOHOL DEHYDROGENASE; ENZYME; FORMATE DEHYDROGENASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; ISOTOPE; MALATE DEHYDROGENASE; MALATE DEHYDROGENASE (OXALOACETATE DECARBOXYLATING) (NAD+); MALATE DEHYDROGENASE-(OXALOACETATE-DECARBOXYLATING) (NAD+); PHOSPHOGLUCONATE DEHYDROGENASE;

CHEMICAL MODEL; KINETICS; METABOLISM; ORGANIC CHEMISTRY; REVIEW;

ALCOHOL DEHYDROGENASE; CHEMISTRY, ORGANIC; ENZYMES; FORMATE DEHYDROGENASES; GLUCOSEPHOSPHATE DEHYDROGENASE; ISOTOPES; KINETICS; MALATE DEHYDROGENASE; MODELS, CHEMICAL; PHOSPHOGLUCONATE DEHYDROGENASE;

EID: 0032247029     PISSN: 10256016     EISSN: None     Source Type: Journal    
DOI: 10.1080/10256019708036327     Document Type: Article

References (19)

1. J. P. Klinman: Kinetic isotope effects in enzymology. Adv. Enzymol. Rel. Areas. Mol. Biol. 46 (1979) 415-494.
2. F. H. Westheimer: The magnitude of the primary kinetic isotope effect for the compounds of hydrogen and deuterium. Chem. Rev. 61 (1961) 265-275.
3. P. F. Cook, J. S. Blanchard and W. W. Cleland: Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions. Biochemistry 19 (1980) 4853-4858.
4. W. W. Cleland: Measurement of isotope effects by the equilibrium perturbation technique. Methods Enzymol. 64 (1980) 104-125.
5. A. Streitweiser Jr., R. H. Jagow, R. C. Fahey and S. Sukuku: Kinetic isotope effects in the acetolysis of deuterated cyclopentyl tosylates. J. Am. Chem. Soc. 80 (1958) 2326-2332.
6. D. W. Parkins: Methods for the determination of competitive and noncompetitive kinetic isotope effects. P. F. Cook (Ed.): Enzyme Mechanism from Isotope Effects, CRC Press, Boca Raton 1991, pp. 269-290.
7. P. M. Weiss: Heavy-atom isotope effects using the isotope ratio mass spectrometer. P. F. Cook (Ed.): Enzyme Mechanism from Isotope Effects, CRC Press, Boca Raton 1991, pp. 291-311.
8. D. M. Kiick: Use of the stable isotope, remote label technique to determine isotope effects for enzyme-catalyzed reactions. P. F. Cook (Ed.): Enzyme Mechanism from Isotope Effects, CRC Press, Boca Raton 1991, pp. 313-329.
9. D. B. Northrop: Steady state analysis of kinetic isotope effects in enzymic reactions. Biochemistry 14, (1975) 2644-2651.
10. P. F. Cook and W. W. Cleland: Mechanistic deductions from isotope effects in multireactant enzyme mechanisms. Biochemistry 20 (1981a) 1790-1796.
11. P. F. Cook and W. W. Cleland: pH Variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent kinetic mechanism of alcohol dehydrogenase. Biochemistry 20, (1981 b) 1805-1816.
12. C.-C. Hwang, A. J. Berdis, M. A. McAllister, W. W. Cleland and P. F. Cook: Oxidative decarboxylation of 6-phosphogluconate by 6-phosphogluconate dehydrogenase proceeds by a stepwise mechanism with NADP and APADP as oxidants. Biochemistry (1998) submitted.
13. W. W. Cleland: Multiple isotope effects in enzyme-catalyzed reactions. P. F. Cook (Ed.): Enzyme Mechanism from Isotope Effects, CRC Press, Boca Raton 1991, pp. 248-265.
14. J. D. Hermes, S. W. Morrical, M. H. O'Leary and W. W. Cleland: Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 2. formate dehydrogenase. Biochemistry 23 (1984) 5479-5488.
15. J. D. Hermes, C. A. Roeske, M. H. O'Leary and W. W. Cleland: Use of multiple isotope effects to determine enzyme mechanisms and intrinsic isotope effects. Malic enzyme and glucose 6-phosphate dehydrogenase. Biochemistry 21 (1982) 5106-5114.
16. W. E. Karsten and P. F. Cook: Stepwise versus concerted oxidative decarboxylation catalyzed by malic enzyme: A reinvestigation. Biochemistry 33 (1994) 2096-2103.
17. P. M. Weiss, S. R. Gavva, B. G. Harris, J. Urbauer, W. W. Cleland and P. F. Cook: Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction. Biochemistry 30 (1991) 5755-5763.
18. W. A. Edens, J. Urbauer and W. W. Cleland: Determination of the chemical mechanism of malic enzyme by isotope effects. Biochemistry 36 (1997) 1141-1147.
19. P. F. Cook (Ed.): Enzyme Mechanism from Isotope Effects, CRC Press, Inc., Boca Raton (1991).