Electron nuclear double resonance determined structures of enzyme reaction intermediates: Structural evidence for substrate destabilization

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

Volumn 54, Issue 14, 1998, Pages 2269-2281

  Makinen, Marvin W ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Electron nuclear double resonance; Electron paramagnetic resonance; Enzyme mechanisms; Enzyme structure; Nitroxyl spin labels; Chymotrypsin

Indexed keywords

AMINE OXIDE; CHYMOTRYPSIN; DRUG DERIVATIVE; ENZYME INHIBITOR; PHENYLALANINE; TRYPTOPHAN;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; ELECTRON SPIN RESONANCE; KINETICS; METABOLISM; SPIN LABELING;

BINDING SITES; CHYMOTRYPSIN; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHENYLALANINE; SPIN LABELS; TRYPTOPHAN;

EID: 0032242182     PISSN: 13861425     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-1425(98)00210-8     Document Type: Article

References (26)

1. G.B. Wells, M.W. Makinen, J. Am. Chem. Soc. 110 (1988) 6343.
2. D. Mustafi, J.R. Sachleben, G.B. Wells, M.W. Makinen, J. Am. Chem. Soc. 112 (1990) 2558.
3. G.B. Wells, D. Mustafi, M.W. Makinen, J. Am. Chem. Soc. 112 (1990) 2566.
4. D. Mustafi, G.B. Wells, H. Joela, M.W. Makinen, Free Rad. Res. Commun. 10 (1990) 95.
5. H. Joela, D. Mustafi, C.C. Fair, M.W. Makinen, J. Phys. Chem. 95 (1991) 9135.
6. D. Mustafi, M.W. Makinen, J. Am. Chem. Soc. 117 (1995) 6739.
7. D. Mustafi, W.E. Boisvert, M.W. Makinen, J. Am. Chem. Soc. 115 (1993) 3674.
8. D. Mustafi, W.E. Boisvert, M.W. Makinen, J. Am Chem. Soc. 115 (1993) 3683.
9. D. Mustafi, H. Joela, M.W. Makinen, J. Magn. Reson. 91 (1991) 497.
10. M.W. Makinen, D. Mustafi, The vanadyl ion: molecular structure of coordinating ligands, in: H. Sigel, A. Sigel (Eds.), Metal Ions in Biological Systems, vol. 31, Marcel Dekker, New York, 1995, pp. 89-127.
11. M.W. Makinen, A.L. Fink, Annu. Rev. Biophys. Bioeng. 6 (1977) 301.
12. S.J. Cartwright, A.L. Fink, CRC Crit. Rev. Biochem. 11 (1981) 145.
13. P. Douzou, 'Cryobiochemistry', New York: Academic Press (1977).
14. L.C. Kuo, J.M. Fukuyama, M.W. Makinen, J. Mol. Biol. 163 (1983) 63.
15. G.B. Wells, D. Mustafi, M.W. Makinen, J. Biol. Chem. 269 (1994) 4577.
16. D. Mustafi, M.W. Makinen, J. Biol. Chem. 269 (1994) 4587.
17. W.P. Jencks, Binding energy, specificity, and enzyme catalysis: the Cerce effect, in: A. Meister (Ed.), Adv. Enzymol. Related Areas Mol. Biol., vol. 43, Wiley-Interscience, New York, 1975, pp. 219-409.
18. G.H. Rist, J.S. Hyde, J. Chem. Phys. 52 (1970) 4633.
19. M.W. Makinen, D. Mustafi, K. Kasa, ENDOR of spinlabels for structure determination: from small molecules to enzyme reaction intermediates, in: L.J. Berliner (Ed.), Biological Magnetic Resonance, Vol. 14, Spin-Labeling IV: The Next Millenium, Plenum Press, New York, 1998, pp. 181-249.
20. P.M. Cotrait, Y. Barrans, Acta Crystallogr. B30 (1974) 510.
21. D. Mustafi, M.M. Knock, R. Shaw, M.W. Makinen, J. Am. Chem. Soc. 119 (1997) 12619.
22. G.P. Hess, Chymotrypsin - chemical properties and catalysis, in: P.D. Boyer (Ed.), The Enzymes, vol. 3, Academic Press, New York, 1971, pp. 213-248.
23. B. Barshop, R. Wrenn, C. Freiden, Anal. Biochem. 130 (1983) 134.
24. R. Wolfenden, Annu. Rev. Biophys. Bioeng. 5 (1976) 271.
25. F.S. Jiang, S.W. Tsai, S. Chen, M.W. Makinen, J. Phys. Chem. B 102 (1998) 4619.
26. R. Chen, D.G. Gorenstein, W.P. Kennedy, G. Love, D. Nurse, R.M. Schultz, Biochemistry 18 (1979) 921.