Effect of betaine administration on metabolism of hepatic glutathione in rats

Archives of Pharmacal Research

Volumn 21, Issue 6, 1998, Pages 790-792

  Kim, Sang Kyum ^a   Kim, Sung Yeon ^a   Kim, Young Chul ^a  

^a Seoul National University   (South Korea)

Author keywords

Betaine; Cysteine; Glutathione; S adenosylhomocysteine (SAH); S Adenosylmethionine (SAM); Trans sulfuration pathway

Indexed keywords

BETAINE; CYSTEINE; GLUTATHIONE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ANIMAL; ARTICLE; DRUG EFFECT; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; METABOLISM; RAT;

ANIMALS; BETAINE; CYSTEINE; FEMALE; GLUTATHIONE; INJECTIONS, INTRAPERITONEAL; LIVER; RATS; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE;

EID: 0032239667     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02976780     Document Type: Article

References (12)

1. Brady, J. F., Li, D., Ishizaki, H., Lee, M., Ning, S. M., Xiao, F. and Yang, C. Y., Induction of cytochrome P450IIE1 and P450IIB1 by secondary ketones and the role of P450IIE1 in chloroform metabolism. Toxicol. Appl. Pharmacol., 100, 342-349 (1989).
2. Finkelstein, J. D., Harris, B. J., Martin, J. J. and Kyle, W. E., Regulation of hepatic betaine-homocysteine methyltransferase by dietary methionine. Biochem. Biophy. Res. Commun., 108, 344-348 (1982).
3. Finkelstein, J. D., Kyle, W. E. and Harris, B. J., Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissue. Arch. Biochem. Biophys., 146, 84-92 (1971).
4. Gaitonde, M. K., A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids. Biochem. J., 104, 627-633 (1967).
5. Garcia R. A. G. and Stipanuk, M. H., The splanchnic organs, liver, and kidney have unique roles in the metabolism of sulfur amino acids and their metabolites in rats. J. Nutr., 122, 1693-1701 (1992).
6. Garcia-Perez, A. and Burg, M. B., Renal medullary organic osmolytes. Physiol. Rev., 71, 1081-1115 (1991).
7. Griffith, O. W., Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem., 106, 207-212 (1980).
8. Kim, S. K., Kim, Y. C. and Kim, Y. C., Effects of singly administered betaine on hepatotoxicity of chloroform in mice. Food Chem. Toxicol., 36, 655-661 (1998).
9. Pohl, L. R., Biochemical toxicology of chloroform. Rev. Biochem. Toxicol., 1, 79-107 (1979).
10. Pohl L. R., Branchflower, R. V., Highet, R. J., Martin, J. L., Nunn, D. S., Monks, T. J., George, J. W. and Hinson, J. A., The formation of diglutathionyl dithiocarbonate as a metabolite of chloroform, bromotrichloromethane and carbon tetrachloride. Drug Metab. Dispos., 9, 334-339 (1981).
11. 6 deficiency of these concentrations in rat liver. Biochem. Biophy. Res. Commun., 205, 1748-1754 (1994).
12. Zhang, F., Warskulat, U., Wettstein, M. and Häussinger, D., Identification of betaine as an osmolyte in rat liver macrophages (Kupffer cells). Gastroenterology, 110, 1543-1552 (1996).