NO/cGMP pathway is involved in exocrine secretion from rat pancreatic acinar cells

Archives of Pharmacal Research

Volumn 21, Issue 6, 1998, Pages 657-663

  Ahn, Seong Hoon ^a   Seo, Dong Wan ^a   Ko, Young Kwon ^a   Sung, Dae Suk ^a   Bae, Gyu Un ^a   Yoon, Jong Woo ^a   Hong, Sung Youl ^a   Han, Jeung Whan ^a   Lee, Hyang Woo ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

Cholecystokinin octapeptide; Cyclic GMP; Exocrine secretion; Nitric oxide

Indexed keywords

AMYLASE; CHOLECYSTOKININ OCTAPEPTIDE; CYCLIC GMP; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL; ARTICLE; DOSE RESPONSE; DRUG ANTAGONISM; IN VITRO STUDY; MALE; METABOLISM; PANCREAS; PHYSIOLOGY; RAT; SECRETION; TIME;

AMYLASES; ANIMALS; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PANCREAS; RATS; SINCALIDE; TIME FACTORS;

EID: 0032239443     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02976753     Document Type: Article

References (16)

1. Bernfeld, P., Amylases, α and β. Method in Enzymol., 1, 149-158 (1955).
2. Cox, R. D., Determination of nitrate and nitrite at the parts or billion level by chemiluminescence. Anal. Chem., 52, 332-335 (1980).
3. Gukovskaya, A. S. and Pandol, S. J., Nitric oxide production regulates cGMP formation and calcium influx in pancreatic acinar cells. Am. J. Physiol., 266, C350-G356 (1994).
4. 2+ influx in pancreatic acinar cells. Gastroenterology, 104, A306 (1993).
5. 2+ entry and amylase secretion from the rat pancreas. Pflugers Arch-Eur. J. Physiol., 434, 25-37 (1997).
6. Ignarro, L. J., Bugo, G. M., Byrns, R. E. and Chaudhuri, G., Endothelium-derived relaxing factor produced and released form artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA, 84, 9265-9269 (1987).
7. Moncada, S., Palmer, R. M. J. and Higgs, E. A., Nitric oxide: physiology and pharmacology. Pharmacol. Rev., 44, 109-14241 (1991).
8. Muallem, S., Calcium transport pathways of pancreatic acinar cells. Annu. Rev. Physiol., 51, 83-105 (1989).
9. Nathan, C. and Hibbs, J. B., Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol., 3, 65-70 (1991).
10. Nathan, C. and Xie, Q. W., Regulation of Biosynthesis of Nitric Oxide. J. Biol. Chem., 269(19), 13725-13728 (1994).
11. Pandol, S. J. and Schoeffield-Payne, M. S., Cyclic GMP mediates the agonist-stimulated increase in plasma membrane calcium entry in the pancreatic acinar cell. J. Biol. Chem., 265, 12846-12853 (1990).
12. Seo, D. W., Nam, S. W., Nam, T. K., Lee, Y. J., Ko, Y. K. and Lee, H. W., Effect of Cholecystokinin-pancreozymin on the Nitric Oxide Synthase Activity and cyclic GMP level in rat pancreatic tissue. Arch. Pharm. Res., 18, 434-439 (1995).
13. Solomon, T. E., Control of exocrine pancreatic secretion. In: Physiology of the Gastrointestinal tract, 2, 1173-1208 (1987).
14. Williams, J. A., Korc, M. and Dormer, R., Action of secretagogues on a new preparation of functionally intact, isolated pancreatic acini. Am. J. Physiol., 4(5), E517-E524 (1978).
15. Wrenn, R. W., Currie, M. G. and Herman, L. E., Nitric oxide participate in the regulation of pancreatic acinar cell secretion. Life Science, 55, N.7. 511-518 (1993).
16. 2+ influx. J. Biol. Chem., 269, 12645-12653 (1994).