Arginine enhances induction of t helper 1 and t helper 2 cytokine synthesis by peyer’s patch αβ T cells and antigen-specific mucosal immune response

Bioscience, Biotechnology and Biochemistry

Volumn 62, Issue 12, 1998, Pages 2334-2340

  Kobayashi, Toshiya ^a,b   Yamamoto, Masafumi ^a,c   Hiroi, Takachika ^c   McGhee, Jerry ^a   Takeshita, Yasuyoshi ^b   Kiyono, Hiroshi ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b SNOW BRAND MILK PRODUCTS CO LTD   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Antigen specific immune response; Arginine; Cytokine synthesis; Peyer s patch T cell

Indexed keywords

ARGININE; CHOLERA TOXIN; CYTOKINE; EPITOPE; IMMUNOGLOBULIN A; TETANUS TOXOID;

ANIMAL; ANIMAL FOOD; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CHEMISTRY; CYTOLOGY; DNA REPLICATION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; MOUSE; MUCOSAL IMMUNITY; PEYER PATCH; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCINTILLATION COUNTING; TH1 CELL; TH2 CELL;

ANIMAL FEED; ANIMALS; ARGININE; CHOLERA TOXIN; CYTOKINES; DNA REPLICATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FECES; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PEYER'S PATCHES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCINTILLATION COUNTING; TETANUS TOXOID; TH1 CELLS; TH2 CELLS;

EID: 0032234736     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.62.2334     Document Type: Article

References (29)

1. Ha, Y. H. and Milner, J. A., Arginine requirements in immature dogs. J. Nutr., 108, 203-210 (1978).
2. Morris, J. G. and Rogers, Q. R., Ammonia intoxication in the near adult cat as a result of a dietary deficiency of arginine. Science, 199, 431-432 (1978).
3. Fahey, J. L., Toxicity and blood ammonia rise resulting from intravenous amino acid administration in man: The protective effect of L-arginine. J. Clin. Invest., 36, 1647-1655 (1957).
4. Batshaw, M. L. and Brusilow, S. W., Treatment of hyperammo-nemic coma caused by inborn errors of urea synthesis. J. Pediatr., 97, 893-900 (1980).
5. Brusilow, S. W. and Batshaw, M. L., Arginine therapy of ar-gininosuccinase deficiency. Lancet, 1, 124-127 (1979).
6. Barbul, A., Rettura, G., Levenson, S. M., and Seifter, E., Arginine: Thymotropic and wound healing promoting agent. Surg. Forum, 28, 101-103 (1977).
7. Barbul, A., Wasserkrug, H. L., Seifter, E., Rettura, G., Levenson, S. M., and Efron, G., Immunostimulatory effects of arginine in normal and injured rats. J. Surg. Res., 29, 228-235 (1980).
8. Barbul, A., Wasserkrug, H. L., Sisto, D. A., Seifter, E., Rettura, G., Levenson, S. M., and Efron, G., Thymic stimulatory actions of arginine. J. Parenter. Enter. Nutr., 4, 446-449 (1980).
9. Barbul, A., Sisto, D. A., Wasserkrug, H. L., Levenson, S. M., Efron, G., and Seifter, E., Arginine stimulates thymic immune function and ameliorates the obesity and the hyperglycemia of genetically obese mice. /. Parenter. Enter. Nutr., 5, 492-495 (1981).
10. Barbul, A., Efron, G., Shawe, T., and Wasserkrug, H. L., Arginine increases the number of T lymphocytes in nude mice. J. Parenter. Enter. Nutr., 13, 7S (1989).
11. Eantigenle, H., Amino acid metabolism in mammalian cell cultures. Science, 130, 432-437 (1959).
12. Reynolds, J. V., Daly, J. M., Zhang, S., Evantash, E., Shou, J., Sigal, R., and Ziegler, M. M., Immunomodulatory mechanisms of arginine. Surgery, 104, 142-151 (1988).
13. Moriguchi, S., Mukai, K., Hiraoka, I., and Kishino, Y., Functional changes in human lymphocytes and monocytes after in vitro incubation with arginine. Nutr. Res., 1, 719-730 (1987).
14. Xu-Amano, J., Kiyono, H., Jackson, R. J., Staats, H. F., Fujihashi, K., Burrows, P. D., Elson, C. O., Pillai, S., and McGhee, J. R., Helper T cell subsets for immunoglobulin A responses: Oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th 2 cells in mucosa associated tissues. J. Exp. Med., 178, 1309-1320 (1993).
15. Taniguchi, T., McGhee, J. R., Coffman, R. L., Beantigenley, K. W., Eldridge, J. H., Takatsu, K., and Kiyono, H., Detection of individual mouse splenic T cells producing IFN-y and IL-5 using the enzyme-linked immunospot (ELISPOT) assay. J. Immunol. Methods, 128, 65-73 (1990).
16. + Th 2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses. Infect. Im-mun., 64, 1516-1525 (1996).
17. Fujihashi, K., McGhee, J. R., Beantigenley, K. W., McPherson, D. T., McPherson, S. A., Huang, C.-M., and Kiyono, H., Cytokine-specific ELISPOT assay: single cell analysis of IL-2, IL-4 and IL-6 producing cells. J. Immunol. Methods, 160, 181-189 (1993).
18. + T cells in the G] phase of cell cycle produce IFN-y and IL-5. J. Immunol., 150, 106-114 (1993).
19. Jackson, R. J., Fujihashi, K., Xu-Amano, J., Kiyono, H., Elson, C. O., and McGhee, J. R., Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant. Infect. Immun., 61, 4272-4279 (1993).
20. McGhee, J. R., Mestecky, J., Elson, C. O., and Kiyono, H., Regulation of IgA synthesis and immune responses by T cells and interleukins. J. Clin. Immunol., 9, 175-199 (1989).
21. Newsholm, P. and Newsholm, E. A., Rates of utilization of glucose, glutamine and oleate and formation of end-products by mouse peritoneal macrophages in culture. Biochem. J., 261, 211-218 (1989).
22. Ardawi, M. S. and Newsholm, E. A., Maximum activities of some enzymes of glycolysis, the tricarboxylic acid cycle and ke-tone-body and glutamine utilization pathways in lymphocytes of the rat. Biochem. J., 208, 743-748 (1982).
23. Crawford, J. and Cohen, H. J., The essential role of L-glutamine in lymphocyte differentiation in vitro. J. Cell. Physiol., 124, 275-282 (1985).
24. Barbul, A., Arginine and immune function. Nutrition, 6, 53-58 (1990).
25. Kay, J. E. and Lindsay, V. J., Polyamine synthesis during lymphocyte activation. Exp. Cell. Res., 77, 428-436 (1973).
26. Kirk, S. J. and Barbul, A., Role of arginine in trauma, sepsis, and immunity. J. Parenter. Enter. Nutr., 14, 226S-229S (1990).
27. Madden, H. P., Breslin, R. J., Wasserkurg, H. L., Efron, G., and Barbul, A., Stimulation of T cell immunity by arginine enhances survival in peritonitis. J. Surg. Res., 44, 658-663 (1988).
28. Freund, H. R., Ryan, J. A., and Fischer, J. E., Amino acid derangements in patients with sepsis. Ann. Surg., 188, 423-430 (1978).
29. Holt, L. E., Synderman, S. E., Norton, P. M., Roitman, E., and Finch, J., The plasma aminogram in kwashiorkor. Lancet, 2, 1343-1348 (1963).