Transcription factor AP1 is involved in basal and okadaic acid-stimulated activity of the human PRL promoter

Molecular Endocrinology

Volumn 12, Issue 8, 1998, Pages 1215-1227

  Caccavelli, L ^a   Manfroid, I ^a   Martial, J A ^a   Muller, M ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROLACTIN; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR PIT 1;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RAT;

EID: 0032230298     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.8.0152     Document Type: Article

References (46)

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2. TRH and EGF induce human prolactin expression via identical multiple cis-elements
3. Regulatory elements controlling pituitary-specific expression of the human prolactin gene
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5. Binding of a 100-kDa ubiquitous factor to the human prolactin promoter is required for its basal and hormone regulated activity
6. Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements
7. M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding
8. An AP-1-like factor and the pituitary-specific factor Pit-1 are both necessary to mediate hormonal induction of human thyrotropin β gene expression
9. Hormonal regulation of the thyrotropin beta-subunit gene by phosphorylation of the pituitary-specific transcription factor Pit-1
10. Pit-1 binding sites mediate transcriptional responses to cyclic adenosine 3',5'-monophosphate through a mechanism that does not require inducible phosphorylation of Pit-1
11. A Pit-1 phosphorylation mutant can mediate both basal and induced prolactin and growth hormone promoter activity
12. Okadaic acid, a protein phosphatase inhibitor, enhances transcription of a reporter gene containing sequence A of the human prolactin promoter
13. Rapamycin, FK506 and cyclosporin A inhibit human prolactin gene
14. Signal integration at the level of protein kinases, protein phosphatases and their substrates
15. Transcriptional attenuation following cAMP induction requires PP1-mediated dephosphorylation of CREB
16. Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation
17. Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signalling
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21. A novel human serine/threonine protein phosphatase, which possesses four tetratricopeptide repeat motifs and colocalizes to the nucleus
22. Activin increases phosphorylation and decreases stability of the transcription factor Pit-1 in MtTW15 somatotrope cells
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24. Transcriptional induction of the human prolactin gene by cAMP requires two cis-acting elements and at least the pituitary-specific factor Pit-1
25. Casein kinase II is a negative regulator of c-jun DNA binding and AP1 activity
26. Glycogen kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells
27. Ha-ras augments c-jun activity and stimulates phosphorylation of its activation domain
28. Oncogenic and transcriptional cooperation with Ha-ras requires phosphorylation of c-jun on serine 63 and 73
29. c-jun N-terminal phosphorylation correlates with activation of the JNK, and not the ERK, subgroup of mitogen activated protein kinases
30. JunD phosphorylation, and expression of AP-1 DNA binding activity modulated by serum growth factors in quiescent murine 3T3T cells
31. The Jun proto-oncogene is positively auto-regulated by its product Jun/AP1
32. Phosphorylation of c-jun mediated by MAP kinase
33. Inhibition of protein phosphatases by okadaic acid induces AP1 in human T cells
34. Activation of AP-1 by okadaic acid in mouse keratinocytes associated with hyperphosphorylation of c-jun
35. Okadaic acid-dependent induction of the urokinase-type plasminogen activator gene associated with stabilization and autoregulation of c-jun
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37. Phosphorylation of c-Fos at the C-terminus enhances its transforming activity
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39. Thyroid hormone inhibits the human prolactin gene promoter by interfering with activating protein-1 and oestrogen stimulations
40. The ras and protein kinase C signalling pathways are functionally antagonistic in GH4 neuroendocrine cells
41. The c-jun δ-domain inhibits neuroendocrine promoter activity in a DNA sequence and pituitary specific manner
42. Luciferase reporter gene vectors for analysis of promoters and enhancers
43. Phorbol ester-inducible genes contains a common cis element recognised by TPA modulated trans-acting factor
44. Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: Dependence on cyclic AMP-inducible elements
45. Several distinct 'CCAAT' box binding proteins coexist in eukaryotic cells
46. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding