Divergent pathways regulate ligand-independent activation of ERα in SK-N-BE neuroblastoma and COS-1 renal carcinoma cells

Molecular Endocrinology

Volumn 12, Issue 6, 1998, Pages 835-841

  Patrone, C ^a   Gianazza, E ^a   Santagati, S ^a   Agrati, P ^a   Maggi, A ^a  

^a NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; GROWTH FACTOR RECEPTOR; INSULIN; LIGAND; MEMBRANE RECEPTOR; PROTEIN P21; SERINE; STEROID RECEPTOR; TYROSINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CANCER CELL; CELL MEMBRANE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; KIDNEY CARCINOMA; LIGAND BINDING; NERVOUS SYSTEM; NEUROBLASTOMA; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSACTIVATION;

EID: 0032230260     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.6.0114     Document Type: Article

References (42)

1. Steroids and brain function
2. Hippocampus: A target for estrogen action in mammalian brain
3. Steroid-hormone receptors: Many actors in search of plot
4. The nuclear receptor superfamily: The second decade
5. Molecular mechanism of action of steroid/thyroid receptor superfamily members
6. Cloning of a novel receptor expressed in rat prostate and ovary
7. Human estrogen receptor cDNA: Sequence, expression and homology to v-erb-A
8. Localization of the oestradiol-binding and putative DNA-binding domains of the human estrogen receptors
9. The human estrogen receptor has two independent nonacidic transcription activation functions
10. Identification of two transactivation domains in the mouse oestrogen receptor
11. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions
12. Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors
13. Phosphorylation of serine 530 facilitates hormone-dependent transcriptional activation of the chicken progesterone receptor
14. Glucocorticoid receptors in ATP-depleted cells. Dephosphorylation, loss of hormone binding, HSP90 dissociation and ATP-dependent cycling
15. Uterine estrogen receptor in vivo: Phosphorylation of nuclear specific forms on serine residues
16. Modulation of transcriptional activation by ligand-dependent phosphorylation of the human estrogen receptor A/B region
17. Identification of charged residues in a N-terminal portion of the hormone-binding domain of the human estrogen receptor important in transcriptional activity of the receptor
18. Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor
19. Characterization of ligand-dependent phosphorylation of the estrogen receptor
20. Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor
21. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF7 cells
22. Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element
23. Dopaminergic and ligand-independent activation of steroid hormone receptors
24. Coupling of dual signalling pathways: Epidermal growth factor action involves the estrogen receptor
25. Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate and insulin-like growth factor-1
26. Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3
27. Activation of the estrogen receptor through phosphorylation of mitogen-activated protein kinase
28. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
29. Cross coupling between insulin and estrogen receptor in human neuroblastoma cells
30. Activation of estrogen receptor mediates growth arrest and differentation of a neuroblastoma cell line
31. Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity
32. Oligonucleotide squelching reveals the mechanism of estrogen receptor autologous down-regulation
33. Interaction of proteins with transcriptionally active estrogen receptors
34. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
35. Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine
36. Costitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein
37. A 67 Kda non-hormone binding estradiol-receptor is present in human mammary cancers
38. Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone
39. Radiohistochemical localization of insulin receptors in the adult and developing rat brain
40. Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression
41. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding