Pontine injections of nitric oxide synthase inhibitor L-NAME consolidate episodes of REM sleep in the rat

Sleep Research Online

Volumn 1, Issue 1, 1998, Pages 41-48

  Okabe, Shinichi ^b   Sanford, Larry D ^b   Veasey, Sigrid C ^b   Kubin, Leszek ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; MALE; METABOLISM; PHYSIOLOGY; PONS; RAT; REM SLEEP; SLEEP STAGE; SPRAGUE DAWLEY RAT; TIME;

ANALYSIS OF VARIANCE; ANIMALS; ENZYME INHIBITORS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PONS; RATS; RATS, SPRAGUE-DAWLEY; SLEEP STAGES; SLEEP, REM; TIME FACTORS;

EID: 0032229479     PISSN: 1096214X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Arnaud P, Gauthier P, Gottesman C. Atropine effects on the intermediate stage and paradoxical sleep in rats. Psychopharmacology 1994; 116: 304-8.
2. Ayers N, Kapás L, Kruger JM. Circadian variation of nitric oxide synthase activity and cytosolic protein levels in rat brain. Brain Research 1996; 707: 127-30.
3. ωnitro-L-arginine methyl ester of the electrocortical arousal response in rats. British Journal of Pharmacology 1993; 108: 858-60.
4. Benington JH, Heller HC. Monoaminergic and cholinergic modulation of REM-sleep timing in rats. Brain Research 1995; 681: 141-6.
5. Borbély AA, Neuhaus HU. Sleep-deprivation: Effect on sleep and EEG in the rat. Journal of Comparative Physiology 1979; 133: 71-87.
6. Bourgin P, Escourrou P, Gaultier C, Adrien J. Induction of rapid eye movement sleep by carbachol infusion into the pontine reticular formation in the rat. NeuroReport 1995; 6: 532-6.
7. G-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circulation Research 1993; 72: 387-95.
8. Cespuglio R, Burlet S, Marinesco S, Robert F, Jouvet M. Détection voltamétrique du NO cérébral chez le rat. Variations du signal àtravers le cycle veille-sommeil. C. R. d'Academie des Sciences (Paris) 1996; 319: 191-200.
9. Dugovic C, van den Broeck WAE, de Ryck M, Clincke GHC. Inhibition of nitric oxide synthesis induces opposite effects on deep slow wave sleep and paradoxical sleep in rats. Sleep Research 1995; 24A: 119.
10. Dun NJ, Dun SL, Förstermann U. Nitric oxide synthase immunoreactivity in rat pontine medullary neurons. Neuroscience 1994; 59: 429-45.
11. Dzoljic MR, de Vries R. Nitric oxide synthase inhibition reduces wakefulness. Neuropharmacology 1994; 33: 1505-9.
12. Dzoljic MR, de Vries R, van Leeuwen R. Sleep and nitric oxide: Effects of 7-nitro idazole, inhibitor of brain nitric oxide synthase. Brain Research 1996; 718: 145-50.
13. Garthwaite J, Boulton CL. Nitric oxide signaling in the central nervous system. Annual Review of Physiology 1995; 57: 683-706.
14. Gnadt JW, Pegram GV. Cholinergic brainstem mechanisms of REM sleep in the rat. Brain Research 1986; 384: 29-41.
15. Giuditta A, Ambrosini MV, Montagnese P, Mandile P, Cotugno M, Zucconi GG, Vescia S. The sequential hypothesis of the function of sleep. Behavioral Brain Research 1995; 69: 157-66.
16. Guerrero JM, Pablos MI, Ortiz GG, Agapito MT, Reiter RJ. Nocturnal decreases in nitric oxide and cyclic GMP contents in the chick brain and their prevention by light. Neurochemistry International 1996; 29: 417-21.
17. Guimarães FS, de Aguiar JC, Del Bel EA, Ballejo G. Anxiolytic effect of nitric oxide synthase inhibitors microinjected into the dorsal central grey. NeuroReport 1994; 5: 1929-32.
18. Horner RL, Sanford LD, Annis D, Pack AI, Morrison AR. Serotonin at the laterodorsal tegmental nucleus suppresses rapid-eye-movement sleep in freely behaving rats. Journal of Neuroscience 1997 (in press).
19. Iadecola C, Xu X, Zhang F, Hu J, el-Fakahany EE. Prolonged inhibition of brain nitric oxide synthase by short-term systemic administration of nitro-l-arginine methyl ester. Neurchemical Research 1994; 19: 501-5.
20. Imeri L, Bianchi S, Angeli P, Mancia M. Selective blockade of different brain stem muscarinic receptor subtypes: Effects on the sleep-wake cycle. Brain Research 1994; 636: 68-72.
21. Jones BE. Paradoxical sleep and its chemical/structural substrates in the brain. Neuroscience 1991; 40: 637-56.
22. Kapás L, Kimura M, Fang J, Krueger JM. Microinjection of nitric oxide synthesis inhibitor into the brainstem suppresses sleep in rats. Society for Neuroscience Abstracts 1993; 19: 1814.
23. Kapás L, Fang J, Krueger JM. Inhibition of nitric oxide synthesis inhibits rat sleep. Brain Research 1994; 664: 189-96.
24. Kodama T, Takahashi Y, Honda Y Enhancement of acetylcholine release during paradoxical sleep in the dorsal tegmental field of the cat brainstem. Neuroscience Letters 1990; 114: 277-82.
25. Leonard TO, Lydic R. Pontine nitric oxide modulates acetylcholine release, rapid eye movement sleep generation, and respiratory rate. Journal of Neuroscience 1997; 17: 774-85.
26. Lorrai DS, Hull EM. Nitric oxide increases dopamine and serotonin release in the medial preoptic area. NeuroReport 1993; 5: 87-9.
27. Lydic R, McCarley RW, Hobson JA. Serotonin neurons and sleep I. Long term recordings of dorsal raphe discharge frequency and PGO waves. Archives Italiennes de Biologie 1987; 125: 317-43.
28. Mastrangelo D, de Saint Hilaire-Kafi Z, Gaillard J-M. Effects of Clonidine and alpha-methyl-p-thyrosine on the carbachol stimulation of paradoxical sleep. Pharmacology Biochemistry and Behavior 1994; 48: 93-100.
29. Matsumara H, Gerashchenko D, Satoh S, Nakajima T, Kasahara K, Hayashi O. Prostaglandin D2 and nitric oxide: key factors underlying the regulation of slow-wave sleep and paradoxical sleep in the rat brain. Sleep Research 1995; 24A: 134.
30. Moncada S, Palmer RJM, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacological Reviews 1991; 43: 109-42.
31. Okabe S, Sanford LD, Veasey SC, Kubin L. Effect of nitric oxide synthase inhibitor microinjections into rat mesopontine tegmentum on sleep. Sleep Research 1995; 24A: 50.
32. Pape H-Ch. Nitric oxide: an adequate modulatory link between biological oscillators and control systems in the mammalian brain. Seminars in the Neurosciences 1995; 7: 329-40.
33. Portas CM, Thakkar M, Rainnie D, McCarley RW. Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat. Journal of Neuroscience 1996; 16: 2820-8.
34. Prast H, Fischer H, Werner E, Werner-Felmayer G, Philippu A. Nitric oxide modulates the release of acetylcholine in the ventral striatum of the freely moving rat. Archives of Pharmacology 1995; 352: 67-73.
35. Rampin C, Cespuglio R, Chastrette N, Jouvet M. Immobilization stress induces a paradoxical sleep rebound in rat. Neuroscience Letters 1991; 126: 113-8.
36. Sanford LD, Tejani-Butt SM, Ross RJ, Morrison AR. Amygdaloid control of alerting and behavioral arousal in rats: Involvement of serotonergic mechanisms. Archives Italiennes de Biologie 1995; 134: 81-99.
37. Shiromani PJ, Fishbein W. Continuous pontine cholinergic microinfusion via mini-pump induces sustained alterations in rapid eye movement (REM) sleep. Pharmacology Biochemistry and Behavior 1986; 25: 1253-61.
38. Trachsel L, Tobler I, Achermann P, Borbély AA. Sleep continuity and REM-nonREM cycle in the rat under baseline conditions and after sleep deprivation. Physiology and Behavior 1991; 49: 575-80.
39. Taguchi O, Kubin L, Pack AI. Evocation of postural atonia and respiratory depression by pontine carbachol in the decerebrate rat. Brain Research 1992; 595: 107-15.
40. Ursin R, Sterman MB. A Manual for Standardized Scoring of Sleep and Waking States in the Adult Cat. Los Angeles, CA: Brain Information Service, Brain Research Institute, University of California, 1981.
41. Vincent SR, Kimura H. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 1992; 46: 755-84.
42. Williams JA, Vincent SR, Reiner PB. Nitric oxide production in rat thalamus changes with behavioral state, local depolarization, and brainstem stimulation. Journal of Neuroscience 1997; 17: 420-7.
43. Williams JA, Comisarow J, Day J, Fibiger HC, Reiner PB. State-dependent release of acetylcholine in rat thalamus measured by in vivo microdialysis. Journal of Neuroscience 1994; 14: 5236-42.
44. Zhuo M, Kandel ER, Hawkins RD. Nitric oxide and cGMP can produce either synaptic depression or potentiation depending on the frequency of presynaptic stimulation in the hippocampus. NeuroReport 1994; 5: 1033-6.