Solid phase synthesis of hydantoins by thermal cyclization and screening of reaction conditions using APOS 1200

Molecular Diversity

Volumn 4, Issue 3, 1998, Pages 165-171

  Karnbrock, Wilhelm ^a   Deeg, Martin ^b   Gerhardt, Jürgen ^c   Rapp, Wolfgang ^a  

^a Rapp Polymere GmbH   (Germany)

^b CAT GmbH and Co Chromatographie und Analysentechnik KG   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

APOS 1200; Combinatorial chemistry; FT ATR IR spectroscopy; Hydantoin; Solid phase synthesis; TentaGel; Thermal cyclization

Indexed keywords

AMINO ACID; HYDANTOIN DERIVATIVE; METHANOL; PEPTIDE; WATER;

ARTICLE; CHEMICAL MODEL; CHEMISTRY; COMBINATORIAL CHEMISTRY; INFRARED SPECTROPHOTOMETRY; ISOLATION AND PURIFICATION; MASS FRAGMENTOGRAPHY; PH; SYNTHESIS; TEMPERATURE; TIME;

AMINO ACIDS; COMBINATORIAL CHEMISTRY TECHNIQUES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HYDANTOINS; HYDROGEN-ION CONCENTRATION; METHANOL; MODELS, CHEMICAL; PEPTIDES; SPECTROPHOTOMETRY, INFRARED; TEMPERATURE; TIME FACTORS; WATER;

EID: 0032227349     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009659303984     Document Type: Article

References (15)

1. a. Früchtel, J. and Jung, G., Angew. Chem., 108 (1996) 19-46.
2. b. Balkenhohl, F., von dem Bussche-Hünnefeld, C., Lansky, A. and Zechel, C., Angew. Chem., 108 (1996) 2436-2488.
3. c. Brown, A., Hermkens, P., Ottenheijm, H. and Rees, D., Synlett, (1998) 817-827.
4. a. Hobbs DeWitt, S., Kiely, J., Stankovic, C., Schroeder, M., Reynolds Cody, D. and Pavia, M., Proc. Natl. Acad. Sci. USA, 90 (1993) 6909-6913.
5. b. Dressman, B., Spangle, L. and Kaldor, S., Tetrahedron Lett., 37 (1996) 937-940.
6. c. Hanessian, S. and Yang, R., Tetrahedron Lett., 37 (1996) 5835-5838.
7. d. Matthews, J. and Rivero, R., J. Org. Chem., 62 (1997) 6090-6092.
8. e. Kim, S., Ahn, S., Koh, J., Lee, J., Ro, S. and Cho, H., Tetrahedron Lett., 38 (1997) 4603-4606.
9. f. Gong, Y., Najdi, S., Olmstead, M. and Kurth, M., J. Org. Chem., 63 (1998) 3081-3086.
10. g. Park, K., Olmstead, M. and Kurth, M., J. Org. Chem., 63 (1998) 6079-6585.
11. h. Bhalay, G., Cowell, D., Hone, N., Scobie, M. and Baxter, A., Mol. Div., 3 (1998) 195-198.
12. i. Bauser, M., Winter, M., Valenti, C., Wiesmüller, K.-H. and Jung, G., Mol. Div., 3 (1998) 257-260.
13. Joshi, P., Parmar, S. and Rastogi, V., J. Heterocyc. Chem., 16 (1979) 607-608.
14. Gremlich, H.-U. and Berets, S., Appl. Spectrosc., 50 (1996) 532-536.
15. Smith, J., Liras, J., Schneider, S. and Anslyn, E., J. Org. Chem., 61 (1996) 8811-8818.