Prepartion of 5-fluorouracil-poly-α, β(2-hydroxyethy1)-DL-asparamide and in-vivo release in rabbit

Yaoxue Xuebao

Volumn 33, Issue 12, 1998, Pages 906-909

  Zhu, Kaling ^a   Tang, Guping ^a   Chen, Qiqi ^a   Zhang, Xiaodong ^a   Zhou, Shuqing ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

5 Fluorouracil; In vivo release; Initial burst; Poly , (hydroxyalkyl) DL asparamide

Indexed keywords

5 FLUOROURACIL POLY ALPHA,BETA (2 HYDROXYETHYL)ASPARAMIDE; 5-FLUOROURACIL-POLY-ALPHA,BETA-(2-HYDROXYETHYL)ASPARAMIDE; DRUG CARRIER; DRUG DERIVATIVE; FLUOROURACIL; PEPTIDE; POLYMER;

ANIMAL; ARTICLE; DRUG IMPLANT; FEMALE; MALE; METABOLISM; RABBIT; RANDOMIZATION;

ANIMALS; DRUG CARRIERS; DRUG IMPLANTS; FEMALE; FLUOROURACIL; MALE; PEPTIDES; POLYMERS; RABBITS; RANDOM ALLOCATION;

EID: 0032226325     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Antoni G, Neri P, Pedersen TG, et al. Hydrodynamic properties of a new plasma expander: polyhydroxyethyl asparamide. Biopolymers, 1974, 13 :163
2. Tabata Y, Takebayashi Y, Ueda T, et al. A formulation method using D, L-lactic acid oligomer for protein release with reduced intial burst. J Controlled Release, 1993,23:55
3. Ralph W, Niven, Pypacek F, et al. Solute absorption from the airways of the isolated rat lung ( III ). Absorption of several peptidase resistant synthetic polypeptides: poly-( 2-hydroxyethyl )-aspartamides. Pharm Res, 1990,7:990
4. Giammona G, Carlisi B, Carallaro G, et al. A new water-soluble synthetic polymer α, β-polyasparthydrazide, as potential plasma expander and drug carrier. J Conrtolled Release, 1994,29:63
5. Filipovic J, Grcic D, Maysinger B, et al. Macromolecular prodrugs ( IV ) . Alginate-chitosan microspheres of PHEA-L-dopa adduct. Int J Pharm, 1995,116:39
6. Claudia S, Leopold, David R, et al. In vitro study for the assessment of poly (L-aspartic acid) as a drug carrier for colon-specific drug delivery. Int J Pharm, 1995,126:139