Influence of phospholipids and sequential kinase activities on tau in vitro

Advances in Experimental Medicine and Biology

Volumn 446, Issue , 1998, Pages 181-201

  Shea, T B ^a   Ekinci, F J ^a  

^a UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPID; PHOSPHOTRANSFERASE; TAU PROTEIN;

ALZHEIMER DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVITY; HUMAN; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0032223791     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-4869-0_11     Document Type: Conference Paper

References (84)

1. Microtubule-binding domain of tau proteins
2. Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein
3. Tau confers drug-stability but cold-stability to microtubules in living cells
4. Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease
5. Phosphorylation of tau proteins to a state like that in Alzheimer's brain in catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids
6. Separation of the different microtubule-associated tau proteins from bovine brain and their mode II phosphorylation by Ca2+/phospholipid-dependent protein kinase C
7. Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5
8. The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule-binding region
9. Lipid stimulation of tau polymerization into Alzheimer straight filament-like structures
10. Tau is enriched on dynamic microtubules in the distal region of growing axons
11. Hyperphosphorylation of human tau by brain kinase PK40erk beyond phosphorylation by cAMP-dependent PKA: Relation to Alzheimer's disease
12. Phosphorylation events mediated by protein kinase Cα and ε participate in regulation of tau steady-state levels and generation of certain "Alzheimer-like" phospho-epitopes
13. Abnormal tau phosphorylation at ser-396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
14. Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain
15. The phosphatidylinositol-binding site of microtubule-associated protein MAP2
16. Inhibition of neuronal polarity by tau antisense oligonucleotides in primary cerebellar neurons
17. The effect of antisense oligonucleotides on neurite formation of cultured cerebellar macroneurons
18. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin
19. Hyperphosphorylation of tau and filopodial retraction following microinjection of protein kinase C catalytic subunits
20. Alteration in tau antigenicity and electrophoretic migration by PKCα under cell-free conditions
21. Proteolysis of protein kinase C: mM and μM calcium-requiring calpains have different abilities to generate, and degrade, the free catalytic subunit, protein kinase M
22. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau
23. Mitogen activated protein (MAP) kinase transform tau protein into an Alzheimer-like state
24. Tau protein function in living cells
25. Tau phosphorylation in human, primate and rat brain: Evidence that a pool of tau is highly phosphorylated in vivo and is rapidly dephosphorylated in vitro
26. p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2AI
27. Tau protein and the neurofibrillary pathology of Alzheimer's disease
28. The abnormal phosphorylation of tau proteins at ser-202 in Alzheimer's disease recapitulates phosphorylation during development
29. Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: Identification of phosphorylation sites in tau protein
30. Alzheimer's disease: Paired helical filaments and cytomembranes
31. Tau protein becomes long and stiff upon phosphorylation: Correlation between paracrystalline structure and degree of phosphorylation
32. Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localization of the kinase
33. Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains
34. The protein kinase C activator phorbol-12-myristate-13-acetate enhances cyclic AMP accumulation in pheochromocytoma cells
35. Proteolysis of tau by calpain
36. Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner
37. A cdc-related kinase PSSALRE/cdk5 is homologous with the 30kDa subunit of tau protein kinase II, a proline-directed kinase associated with microtubules
38. The molecular and cellular biology of tau
39. MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: An immunochemical study of cultured rat cerebellum
40. Tau protein and Alzheimer's disease
41. Morphological and structural charactierization of lipid-induced tau polymers
42. Phospholipids inhibit proteolysis of protein kinase Cα by mM calcium-requiring calpain
43. A serine-proline change in the Alzheimer's disease-associated epitope Tau-2 results in altered secondary structure, but phosphorylation overcomes the conformational gap
44. Stimulation of MAP kinase by v-raf transformation of fibroblasts falls to induce hyerphosphorylation of transfected tau
45. Implication of brain cdc2 and MAP kinases in the phosphorylation of tau protein in Alzheimer's disease
46. The microtubule binding domain of tau protein
47. A new molecular interactor for tau protein
48. A new molecular interactor for tau protein
49. Phosphorylation, calpain proteolysis and tubulin binding of recombinant tau isoforms
50. Application of synthetic phospho- and unphospho-peptides to identify phosphorylation sites in a subregion of the tau molecule, which is modified in Alzheimer's disease
51. p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons
52. Tau as a marker for Alzheimer's disease
53. Glycogen synthase kinase 3 and the Alzheimer's disease-like state of microtubule-associated protein tau
54. Tau domains, phosphorylation, and interactions with microtubules
55. A spatial gradient of tau protein phosphorylation in nascent axons
56. Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
57. Prolin-directed and non-proline-directed phosphorylation of PHF-tau
58. PHF-tau a from Alzheimer's brain comprises four species OR SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3β
59. Brain proline-directed protein kinase phosphorylates tau OR sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments
60. Networking with proline-directed protein kinases implicated in tau phosphorylation
61. Mitogen-activated protein kinases: Versatile transducers for cell signalling
62. Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP
63. Phosphorylated tau epitope of Alzheimer's disease is coupled to axon development in the avian central nervous system
64. Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY-5Y
65. AD-like tau phosphorylation in human neuroblastoma cells following PKC hyperactivation is mediated by MAP kinase
66. Hyperphosphorylation of the cytoskeletal protein tau by the MAP-kinase PK40erk: Regulation by prior phosphorylation with cAMP-dependent protein kinase A
67. Complementary distribution of tau proteins in different phosphorylation states within growing axons
68. Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5
69. Microtubule-associated protein tau is required for axonal neurite elaboration by neuroblastoma cells
70. Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: Initiation by kinase A and restriction by kinase C
71. Respective roles of neurofilaments, microtubules, MAPIB and tau in the outgrowth and stabilization of axonal neurites
72. Phosphatase inhibition in human neuroblastoma cells alters tau antigenicity and renders it incompetent to associate with exogenous microtubules
73. Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: Involvement of calpain-mediated hydrolysis of protein kinase C
74. Modulation of GSK-3-catalyzed phosphorylation of microtubule-associated protein tau by non-proline-dependent protein kinases
75. Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline dependent kinases and GSK-3
76. 2+-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles
77. Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location
78. The difference in the binding of phosphatidylinositol distinguishes MAP2 from MAP2C and tau
79. Increased microtubule stability and alpha-tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau
80. Altered tau and neurofilament proteins in neurodegenative diseases: Diagnostic implications for Alzheimer's disease and Lewy body dementias
81. PHF tau (A68): From pathological marker to potential mediator of neuronal dysfunction and degeneration in Alzheimer's disease
82. Praline-directed phosphorylation of human tau protein
83. Interaction with model membrane system induces secondary structure in amino-terminal fragments of parathyroid hormone-related protein
84. Calpain-induced proteolysis of normal human tau and tau associated with paired helical filaments