N2,7-bis(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine: Identical noncyclic adducts with 1,3-dichloropropene epoxides and methylglyoxal

Chemical Research in Toxicology

Volumn 11, Issue 12, 1998, Pages 1536-1542

  Schneider, Manfred ^a,b   Quistad, Gary B ^a   Casida, John E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Western Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DICHLOROPROPENE EPOXIDE; 2 N,7 BIS(1 HYDROXY 2 OXOPROPYL) 2' DEOXYGUANOSINE; EPOXIDE; UNCLASSIFIED DRUG; 1,3 DICHLORO 1 PROPENE; 1,3-DICHLORO-1-PROPENE; ALLYL COMPOUND; DEOXYGUANOSINE; DRUG DERIVATIVE; INSECTICIDE; METHYLGLYOXAL; N BIS(1 HYDROXY 2 OXOPROPYL) 2' DEOXYGUANOSINE; N-BIS(1-HYDROXY-2-OXOPROPYL)-2'-DEOXYGUANOSINE;

AGRICULTURE; ARTICLE; CATALYSIS; CIS TRANS ISOMERISM; DNA ADDUCT; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MUTAGENICITY; PEST CONTROL; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION REACTION; ULTRAVIOLET SPECTROPHOTOMETRY;

ALLYL COMPOUNDS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANOSINE; INSECTICIDES; MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION-REDUCTION; PYRUVALDEHYDE; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0032217229     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9801256     Document Type: Article

References (2)

1. Neudecker, T., and Henschler, D. (1986) Mutagenicity of chloroolefins in the Salmonella/mammalian microsome test. III. Metabolic activation of the allylic chloropropenes allyl chloride, 1,3-dichloropropene, 2,3-dichloro-1-propene, 1,2,3-trichloropropene, 1,1,2,3-tetrachloro-2-propene and hexachloropropene by S9 mix via two different metabolic pathways. Mutat. Res. 170, 1-9.
2. Watson, W. P., Brooks, T. M., Huckle, K. R., Hutson, D. H., Lang, K. L., Smith, R. J., and Wright, A. S. (1987) Microbial mutagenicity studies with (Z)-1,3-dichloropropene. Chem.-Biol. Interact. 61, 17-30.