Hypotensive mechanism of [Leu13]motilin in dogs in vivo and in vitro

Canadian Journal of Physiology and Pharmacology

Volumn 76, Issue 12, 1998, Pages 1103-1109

  Iwai, Takeshi ^a   Nakamura, Hiroyuki ^a   Takanashi, Hisanori ^b   Yogo, Kenji ^a   Ozaki, Ken Ichi ^a   Ishizuka, Nobuhiko ^a   Asano, Tadashi ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b Chugai Biopharmaceuticals Inc   (United States)

Author keywords

Anesthetized dog; Endothelium; Gastrointestinal motility; Hemodynamics; Hypotension; Mesenteric artery; Motilin; Nitric oxide

Indexed keywords

MOTILIN; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TRIFLUOROACETIC ACID; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CYCLOPEPTIDE; GASTROINTESTINAL AGENT; GM 109; HORMONE ANTAGONIST; HORMONE RECEPTOR; MOTILIN RECEPTOR; NEUROPEPTIDE RECEPTOR; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA FLOW; ARTERIAL PRESSURE; ARTICLE; DOG; DUODENUM; ENDOTHELIUM; GASTROINTESTINAL MOTILITY; HEART LEFT VENTRICLE PRESSURE; HEART RATE; HYPOTENSION; MALE; MESENTERIC ARTERY; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; STOMACH ANTRUM; VASCULAR RESISTANCE; VASODILATATION; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; HEMODYNAMICS;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; DOGS; GASTROINTESTINAL AGENTS; GASTROINTESTINAL MOTILITY; HEMODYNAMIC PROCESSES; HORMONE ANTAGONISTS; HYPOTENSION; MALE; MESENTERIC ARTERIES; MOTILIN; PEPTIDES, CYCLIC; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, NEUROPEPTIDE; VASOCONSTRICTOR AGENTS;

EID: 0032216759     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/cjpp-76-12-1103     Document Type: Article

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