An interleukin 1B allele, which correlates with a high secretor phenotype, is associated with diabetic nephropathy

Cytokine

Volumn 10, Issue 12, 1998, Pages 984-988

  Loughrey, Brona V ^a   Maxwell, A Peter ^a,b   Fogarty, Damian G ^b   Middleton, Derek ^b   Harron, J Camille ^b   Patterson, Christopher C ^a   Darke, Christopher ^c   Savage, David A ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b BELFAST CITY HOSPITAL   (United Kingdom)

^c Welsh Blood Service   (United Kingdom)

Author keywords

Diabetic nephropathy; Insulin dependent diabetes mellitus; Interleukin 1; Interleukin 1 receptor; Interleukin 1 receptor antagonist

Indexed keywords

DNA; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE DURATION; DNA POLYMORPHISM; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; ONSET AGE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; UNITED KINGDOM; CASE CONTROL STUDY; GENETIC POLYMORPHISM; GENETICS; IMMUNOLOGY; NUCLEOTIDE REPEAT;

ALLELES; CASE-CONTROL STUDIES; DIABETIC NEPHROPATHIES; DNA; GENOTYPE; HUMANS; INTERLEUKIN-1; LINKAGE DISEQUILIBRIUM; PHENOTYPE; POLYMORPHISM, GENETIC; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 0032216580     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1998.0388     Document Type: Article

References (23)

1. 1. Raine AEG (1995) The rising tide of diabetic nephropathy - the warning before the flood. Nephrol Dial Transplant 10:460-461.
2. 2. Borch-Johnsen K, Andersen PK, Deckert T (1985) The effect of proteinuria on relative mortality in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 28:590-596.
3. 3. Andersen AR, Christiansen JS, Andersen JK, Kreiner S, Deckert T (1983) Diabetic nephropathy in type 1 (insulin-dependent) diabetes: an epidemiological study. Diabetologia 25:496-501.
4. 4. Osterby R, Parving HH, Hommel E, Jorgensen HE, Lokkegaard H (1990) Glomerular structure and function in diabetic nephropathy. Early to advanced stages. Diabetes 39:1057-1063.
5. 5. Seaquist ER, Goetz FC, Rich S, Barbosa J (1989) Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med 320:1161-1165.
6. 6. Quinn M, Angelico MC, Warram JH, Krolewski AS (1996) Familial factors determine the development of diabetic nephropathy in patients with IDDM. Diabetologia 39:940-945.
7. 7. Melcion C, Lachman L, Killen D, Morel-Maroger L, Striker GE (1982) Mesangial cells, effect of monocyte products on proliferation and matrix synthesis. Trans Proc XIV:559-564.
8. 8. Dinarello CA (1991) Interleukin-1 and interleukin-1 antagonism. Blood 77:1627-1652.
9. 9. Blakemore AIF, Cox A, Gonzalez A-M, Maskill JK, Hughes ME, Wilson RM, Ward JD, Duff GW (1996) Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus. Hum Genet 97:369-374.
10. 10. Tarnow L, Pociot F, Hansen PM, Rossing P, Nielsen FS, Hansen BV, Parving HH (1997) Polymorphisms in the interleukin-1 gene cluster do not contribute to the genetic susceptibility of diabetic nephropathy in caucasian patients with IDDM. Diabetes 46: 1075-1076.
11. 11. Tarlow JK, Blakemore AIF, Lennard A, Solari R, Hughes HN, Steinkasserer A, Duff GW (1993) Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum Genet 91:403-404.
12. 12. Pociot F, Ronningen KS, Bergholdt R, Lorenzen T, Johannesen J, Ye K, Dinarello CA, Nerup J, The Danish Study Group of Diabetes in Childhood (1994) Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes - evidence for polygenicity in man. Autoimmunity 19: 169-178.
13. 13. Bergholdt R, Karlsen AE, Johannesen J, Hansen PM, Dinarello CA, Nerup J, Pociot F, The Danish Study Group of Diabetes in Childhood (1995) Characterization of polymorphisms of an interleukin 1 receptor type 1 gene (IL1RI) promoter region (P2) and their relation to insulin-dependent diabetes mellitus (IDDM). Cytokine 7:727-733.
14. 14. McDowell TL, Symons JA, Ploski R, Forre O, Duff GW (1995) A genetic association between juvenile rheumatoid arthritis and a novel interleukin-1α polymorphism. Arthritis Rheum 38:221-228.
15. 15. Pociot F, Molvig J, Wogensen L, Worsaae H, Nerup J (1992) A Taq I polymorphism in the human interleukin-1β (IL-1β) gene correlates with IL-1β secretion in vitro. Eur J Clin Invest 22:396-402.
16. 2 shows stable interindividual differences. Scand J Immunol 27:705-716.
17. 17. Vlassara H, Brownlee M, Manogue KR, Dinarello CA, Pasagian A (1988) Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodelling. Science 240:1546-1548.
18. 18. Lan HY, Nikolic-Paterson DJ, Mu W, Vannice JL, Atkins RC (1995) Interleukin-1 receptor antagonist halts the progression of established crescentic glomerulonephritis in the rat. Kidney Int 47:1303-1309.
19. 19. Zoja C, Rambaldi A, Remuzzi G (1993) Interleukin-1 and glomerular mesangial cells. Renal Physiol Biochem 16:89-92.
20. 20. Chen W-P, Lin C-Y (1994) Augmented expression of interleukin-6 and interleukin-1 genes in the mesangium of IgM mesangial nephropathy. Nephron 68:10-19.
21. 21. Freedman BI, Yu H, Spray BJ, Rich SS, Rothschild CB, Bowden DW (1997) Genetic linkage analysis of growth factor loci and end-stage renal disease in African Americans. Kidney Int 51:819-825.
22. 22. Fogarty DG, Harron JC, Hughes AE, Nevin NC, Doherty CC, Maxwell AP (1996) A molecular variant of angiotensinogen is associated with diabetic nephropathy in IDDM. Diabetes 45: 1204-1208.
23. 23. Edwards JH (1974) HL-A and disease, the detection of associations. J Immunogenet 1:249-257.