Modelling DNA damage induced by different energy photons and tritium beta-particles

International Journal of Radiation Biology

Volumn 74, Issue 5, 1998, Pages 533-550

  Moiseenko, V V ^a,b   Hamm, R N ^c   Waker, A J ^d   Prestwich, W V ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b LONDON REGIONAL CANCER PROGRAM   (Canada)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

^d CANADIAN NUCLEAR LABORATORIES   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; SINGLE STRANDED DNA; TRITIUM; DNA;

ARTICLE; DNA DAMAGE; DNA STRAND BREAKAGE; DOSE CALCULATION; ENERGY ABSORPTION; IONIZING RADIATION; MODEL; PHOTON; PRIORITY JOURNAL; RADIATION ABSORPTION; RADIATION DOSE; RADIATION INJURY; CHEMICAL STRUCTURE; COMPUTER SIMULATION; METHODOLOGY; MONTE CARLO METHOD; RADIATION EXPOSURE; RADIOBIOLOGY;

COMPUTER SIMULATION; DNA; DNA DAMAGE; DNA, SINGLE-STRANDED; MODELS, MOLECULAR; MONTE CARLO METHOD; PHOTONS; RADIOBIOLOGY; TRITIUM;

EID: 0032214128     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530098141113     Document Type: Article

References (117)

1. AGER, D. D. and DEWEY, W. C., 1990, Calibration of pulsed field gel elcetrophoresis for measurement of DNA double-strand breaks. International Journal of Radiation Biology, 58, 249-259.
2. AGER, D. D., DEWEY, W. C., GARDINER, K., HARVEY, W., JOHNSON, R. T. and WALDREN, C. A., 1990, Measurement of radiation-induced DNA double-strand breaks by pulsed-field gel electrophoresis. Radiation Research, 122, 181-187.
3. AHN, S. Y., NEVALDINE, B. and HAHN, P. J., 1991, Direct measurement by pulsed-field gel electrophoresis of induction and rejoining of x-ray-induced double-strand breaks in cultured mouse cells. International Journal of Radiation Biology, 59, 661-675.
4. APPLEBY, A. and SCHWARZ, H. A., 1969, Radical and molecular yields in water irradiated by γ rays and heavy ions. Journal of Physical Chemistry, 73, 1937-1941.
5. ARNOTT, S. and HUKINS, D. W. L., 1972, Optimized parameters for A-DNA and B-DNA. Biochemical and Biophysical Research Communications, 47, 1504-1510.
6. ARNOTT, S. and HUKINS, D. W. L., 1973, Refinement of the structure of B-DNA and implications for the analyses of x-ray diffraction data from fibers of biopolymers. Journal of Molecular Biology, 81, 93-105.
7. BADIE, C., ILIAKIS, G., FORAY, N., ALSBEITH, G., CEDERVALL, B., CHAVAUDRA, N., PANTELIAS, G., ARLETT, C. and MALAISE, E. P., 1995, Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell lines. Radiation Research, 144, 26-35.
8. BELLI, M., CERA, F., CHERUBINI, R., IANZINI, F., MOSCHINI, G., SAPORA, O., SIMONE, G., TABOCCHINI, M. A. and TIVERON, P., 1994, DNA double-strand breaks induced by low energy protons in V79 cells. International Journal of Radiation Biology, 65, 529-536.
9. BERNSTEIN, F. C., KOETZLE, F. F., WILLIAMS, G. J. B., MEYER, E. F., BRICE, M. D., RODGERS, J. R., KENNARD, O., SHIMANOUCHI, T. and TASUMI, M., 1977, The protein databank. A computer-based archival file for macromolecular structures. Journal of Molecular Biology, 112, 535-542.
10. BLOCHER, D., 1988, DNA double-strand break repair determines the RBE of α-particles. International Journal of Radiation Biology, 54, 761-771.
11. BRENNER, D. J. and WARD, J. F., 1992, Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks. International Journal of Radiation Biology, 61, 737-748.
12. -) in aqueous solution. Journal of Physical Chemistry Reference Data, 17, 513-885.
13. CEDERVALL, B., SIRZEA, F., BRODIN, O. and LEWENSOHN, R., 1994, Less initial rejoining of x-ray-induced DNA double-strand breaks in cells of a small cell (U-1285) compared to a large cell (U-1810) lung carcinoma cell line. Radiation Research, 139, 34-39.
14. CHANDRASEKARAN, R. and ARNOTT, S., 1989, The structures of DNA and RNA helices in oriented fibers. In Numerical Data and Functional Relationship in Science and Technology, New Series VII, 1b, edited by W. Saenger (Berlin: Springer-Verlag), pp. 31-170.
15. CHANDRASEKHAR, S., 1943, Stochastic problems in Physics and astronomy. Reviews of Modern Physics, 15, 1-78.
16. CHAPMAN, J. D. and GILLESPIE, C. J., 1975, Chemical radiosensitization studies with mammalian cells growing in vitro. In Radiation Research, Biomedical, Chemical and Physical Perspectives, edited by O. F. Nygaard, H. Adler and W. K. Sinclair (New York: Academic Press), pp. 752-760.
17. CHARLTON, D. E., GOODHEAD, D. T., WILSON, W. E. and PARETZKE, H. G., 1985, The deposition of energy in small cylindrical targets by high LET radiations. Radiation Protection Dosimetry, 13, 123-125.
18. CHARLTON, D. E., NIKJOO, H. and HUMM, J. L., 1989, Calculation of initial yields of single- and double-strand breaks in cell nuclei from electrons, protons and alpha particles. International Journal of Radiation Biology, 56, 1-19.
19. CHATTERJEE, A. and HOLLEY, W. R., 1990, A general theory of DNA strand break production by direct and indirect effects. Radiation Protection Dosimetry, 31, 241-247.
20. CHATTERJEE, A. and HOLLEY, W. R., 1991, Energy deposition mechanisms and biochemical aspects of DNA strand breaks by ionizing radiation. International Journal of Quantum Chemistry, 39, 709-727.
21. CHATTERJEE, A. and HOLLEY, W. R., 1993, Computer simulation of initial events in the biochemical mechanisms of DNA damage. Advances in Radiation Biology, 17, 181-226.
22. CHATTERJEE, A., KOEHL, P. and MAGEE, J. L., 1986, Theoretical consideration of the chemical pathways for radiation-induced strand breaks. Advances in Space Research, 6, 97-105.
23. DEEBLE, D. J., SCHULZ, D. and VON SONNTAG, C., 1986, Reactions of OH radicals with poly(U) in deoxygenated solutions: sites of OH radical attack and the kinetics of base release. International Journal of Radiation Biology, 49, 915-926.
24. ELKIND, M. M., 1985, DNA damage and cell killing. Cancer, 56, 2351-2363.
25. FRANKENBERG, D., GOODHEAD, D. T., FRANKENBERG-SCHWAGER, M., HARBICH, R., BANCE, D. A. and WILKINSON, R. E., 1986, Effectiveness of 1.5 keV aluminium K and 0.3 keV carbon K characteristic x-rays at inducing DNA double-strand breaks in yeast cells. International Journal of Radiation Biology, 50, 727-741.
26. FREIFELDER, D. and TRUMBO, B., 1969, Matching of single-strand breaks to form double-strand breaks in DNA. Biopolymers, 7, 681-693.
27. HAMM, R. N., TURNER, J. E. and CHATTERJEE, A., 1994, A comparison between two Monte Carlo codes on determination of transient chemical yields. In Computational Approaches in Molecular Radiation Biology, edited by M. N. Varma and A. Chatterjee (New York: Plenum Press), pp. 187-193.
28. HEILMANN, J., TAUCHER-SCHOLZ, G. and KRAFT, G., 1995, Induction of DNA double-strand breaks in CHO-K1 cells by carbon ions. International Journal of Radiation Biology, 68, 153-162.
29. HILL, M. A. and SMITH, F. A., 1994, Calculation of initial and primary yields in the radiolysis of water. Radiation Physics Chemistry, 43, 265-280.
30. HOLLEY, W. R. and CHATTERJEE, A., 1996, Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments. I. Theoretical modeling. Radiation Research, 145, 188-199.
31. 125I assay. International Journal of Radiation Biology, 59, 343-357.
32. ILIAKIS, G. E., METZGER, L., DENKO, N., STAMATO, T. D., 1991a, Detection of DNA double-strand breaks in synchronous cultures of CHO cells by means of asymmetric held inversion gel electrophoresis. International Journal of Radiation Biology, 59, 321-341.
33. JENNER, T. J., BELLI, M., GOODHEAD, D. T., IANZINI, F., SIMONE, G. and TABOCCHINI, M. A., 1992, Direct comparison of biological effectiveness of protons and α-particles of the same LET. III. Initial yield of DNA double-strand breaks in V79 cells. International Journal of Radiation Biology, 61, 631-637.
34. JENNER, T. J., DELARA, G. M., O'NEILL, P. and STEVENS, D. L., 1993, Induction and rejoining of DNA double-strand breaks in V79 4 mammalian cells following γ- and α-irradiation. International Journal of Radiation Biology, 64, 265-273.
35. JONAH, C. D., MATHESON, J. R., MILLER, J. R. and HART, E. J., 1976, Yield and decay of the hydrated electron from 100 ps to 3 ns. Journal of Physical Chemistry, 80, 1267-1270.
36. JONAH, C. D. and MILLER, J. R., 1977, Yield and decay of the OH radical from 200 ps to 3 ns. Journal of Physical Chemistry, 81, 1974-1976.
37. 4He ions. Radiation Research, 136, 190-196.
38. KRISCH, R. E., FLICK, M. B. and TROMBORE, C. N., 1991, Radiation chemical mechanisms of single- and double-strand break formation in irradiated SV40 DNA. Radiation Research, 126, 151-159.
39. LA VERNE, J. A. and PIMBLOTT, S. M., 1991, Scavenger and time dependence of radicals and molecular products in the electron radiolysis of water: examination of experiments and models. Journal of Physical Chemistry, 95, 3196-3206.
40. LA VERNE, J. and PIMBLOTT, S. M., 1993, Yields of hydroxyl radical and hydrated electron scavenging reactions in aqueous solutions of biological interest. Radiation Research, 135, 16-23.
41. LA VERNE, J. A. and PIMBLOTT, S. M., 1995, Electron energy-loss distributions in solid, dry DNA. Radiation Research, 141, 208-215.
42. LEA, D. E., 1955, Actions of radiations on living cells, 2nd edition (Cambridge: Cambridge University Press).
43. LOBRICH, M., COOPER, P. K. and RYDBERG, B., 1996, Nonrandom distribution of DNA double-strand breaks induced by particle irradiation. International Journal of Radiation Biology, 70, 493-503.
44. LOBRICH, M., IKPEME, S. and KIEFER, J., 1994, DNA double-strand break measurement in mammalian cells by pulsed-field gel electrophoresis: an approach using restriction enzymes and gene probing. International Journal of Radiation Biology, 65, 623-630.
45. LOBRICH, M., RYDBERG, B. and COOPER, P., 1995, Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends. Proceedings of National Academy of Sciences, USA, 92, 12 050-12 054.
46. MICHALIK, V. and FRANKENBERG, D., 1996, Two types of double-strand breaks in electron and photon tracks and their relation to exchange-type chromosome aberrations. Radiation and Environmental Biophysics, 35, 163-169.
47. MICHALIK, V., TARTIER, L., SPOTHEIM-MAURIZOT, M. and CHARLIER, M., 1995, Reaction of Hydroxyl Radical with B- and Z-DNA. In Radiation Damage in DNA: Structure/ Function Relationships at Early Times, edited by A. F. Fuciarelli and J. D. Zimbrick (Columbus, OH: Battelle Press), pp. 19-27.
48. MILLIGAN, J. R., AGUILERA, J. A. and WARD, J. F., 1993a, Variation of single-strand break yield with scavenger concentration for plasmid DNA irradiated in aqueous solution. Radiation Research, 133, 151-157.
49. MILLIGAN, J. R., AGUILERA, J. A. and WARD, J. F., 1993b, Variation of single-strand break yield with scavenger concentration for the SV40 minichromosome irradiated in aqueous solution. Radiation Research, 133, 158-162.
50. MILLIGAN, J. R., NG, J. Y.-Y., WU, C. C. L., AGUILERA, J. A., FAHEY, R. C. and WARD, J. F., 1995, DNA repair by thiols in air shows two radicals make a double-strand break. Radiation Research, 143, 273-280.
51. MILLIGAN, J. R. and WARD, J. F., 1994, Yield of single-strand breaks due to attack on DNA by scavenger-derived radicals. Radiation Research, 137, 295-299.
52. MOISEENKO, V. V., EDWARDS, A. A., NIKJOO, H. and PRESTWICH, W. V., 1997, The influence of track structure on the understanding of relative biological effectiveness for induction of chromosomal exchanges in human lymphocytes. Radiation Research, 147, 208-214.
53. MORTON, N. E., 1991, Parameters of the human genome. Proceedings of National Academy of Sciences, U S A, 88, 7474-7476.
54. NIKJOO, H. and CHARLTON, D. E., 1995, Calculation of range and distributions of damage to DNA by high- and low-LET radiations. In Radiation Damage in DNA: Structure/ Function Relationships at Early Times, edited by A. F. Fuciarelli and J. D. Zimbrick (Columbus, OH: Battelle Press), pp. 29-41.
55. NIKJOO, H., GOODHEAD, D. E., CHARLTON, D. E. and PARETZKE, H. G., 1991, Energy deposition in small cylindrical targets by monoenergetic electrons. International Journal of Radiation Biology, 60, 739-756.
56. NIKJOO, H., O'NEILL, P., GOODHEAD, D. T. and TERRISSOL, M., 1997, Computational modelling of low-energy electron-induced DNA damage by early physical and chemical events. International Journal of Radiation Biology, 71, 467-483.
57. NIKJOO, H., O'NEILL, P., TERRISSOL, M. and GOODHEAD, D. T., 1994b, Modeling of radiation-induced DNA damage: the early physical and chemical event. International Journal of Radiation Biology, 66, 453-457.
58. NIKJOO, H., TERRISSOL, M., HAMM, R. N., TURNER, J. E., UEHARA, S., PARETZKE, H. G. and GOODHEAD, D. T., 1994a, Comparison of energy deposition in small cylindrical volumes by electrons generated by Monte Carlo track structure codes for gaseous and liquid water. Radiation Protection Dosimetry, 52, 165-169.
59. 6+ ions in human cells: relative biological effectiveness is dependent on the relative contribution of direct and indirect effects. International Journal of Radiation Biology, 70, 421-427.
60. OSMAN, R., MIASKIEWICZ, K. and WEINSTEIN, H., 1991, Structure-function relations in radiation damaged DNA. In Physical and Chemical Mechanisms in Molecular Radiation Biology, edited by W. A. Glass and M. N. Varma (New York, NY: Plenum Press), pp. 423-452.
61. PARETZKE, H. G., TURNER, J. E., HAMM, R. N., RITCHIE, R. H. and WRIGHT, H. A., 1991, Spatial distribution of inelastic events produced by electrons in gaseous and liquid water. Radiation Research, 127, 121-129.
62. PENNINGS, S., MUYLDERMANS, S., MEERSSEMAN, G. and WYNS, L., 1989, Formation, stability and core histone positioning of nucleosome reassembled on bent and other nucleosome-derived DNA. Journal of Molecular Biology, 207, 183-192.
63. PIMBLOTT, S. M., 1992, Investigation of various factors influencing the effect of scavengers on the radiation chemistry following the high-energy electron radiolysis in water. Journal of Physical Chemistry, 96, 4485-4491.
64. PIMBLOTT, S. M. and LA VERNE, J. A., 1995, Energy loss by electrons in DNA. In Radiation Damage in DNA: Structure/ Function Relationships at Early Times, edited by A. F. Fuciarelli and J. D. Zimbrick (Columbus, OH: Battelle Press), pp. 3-12.
65. PIMBLOTT, S. M., OSMAN, R., SWARTS, S. G., BERNHARD, W. A., WARD, J. F. and DOETSCH, P. W., 1997, Radiation chemistry at the DNA level - a radiation study section workshop. Meeting report, Washington, DC, June 5, 1996. Radiation Research, 147, 511-525.
66. PIMBLOTT, S. M., PILLING, M. J. and GREEN, N. J. B., 1991, Stochastic models of spur kinetics in water. Radiation Physics Chemistry, 37, 377-388.
67. POMPLUN, E., 1991, A new DNA target model for track structure calculations and its first application to I-125 Auger electrons. International Journal of Radiation Biology, 59, 625-642.
68. 123I: Calculation of the Auger electron spectrum and assessment of the strand breakage efficiency. In Biophysical Aspects of Auger Processes, AAPM Symposium Series No. 8, edited by R. W. Howell, V. R. Narra, K. S. R. Sastry and D. V. Rao (Woodbury, NY: American Institute of Physics, Inc.), pp. 121-136.
69. 125I. In Biophysical Aspects of Auger Processes, AAPM Symposium Series No. 8, edited by R. W. Howell, V. R. Narra, K. S. R. Sastry and D. V. Rao (Woodbury, NY: American Institute of Physics, Inc.), pp. 137-152.
70. PRISE, K. M., DAVIES, S. and MICHAEL, B. D., 1993, Evidence for induction of DNA double-strand breaks at paired radical sites. Radiation Research, 134, 102-106.
71. RADFORD, I. A., 1988, The dose-response for low-LET radiation-induced DNA double-strand breakage: methods of measurement and implications for radiation action models. International Journal of Radiation Biology, 54, 1-11.
72. 125I-induced DNA double-strand breaks: use in calibration of the neutral filter elution technique and comparison with x-ray induced breaks. International Journal of Radiation Biology, 48, 555-566.
73. RITCHIE, R. H., HAMM, R. N., TURNER, J. E. and WRIGHT, H. A., 1978, The interaction of swift electrons with liquid water. In Proceedings of the Sixth Symposium on Microdosimetry, edited by J. Booz and H. G. Ebert (London: Harwood), CEC, EUR 6064, pp. 345-354.
74. RITCHIE, R. H., HAMM, R. N., TURNER, J. E., WRIGHT, H. A. and BOLCH, W. E., 1991, Radiation interactions and energy transport in the condensed phase. In Physical and Chemical Mechanisms in Molecular Radiation Biology, edited by W. A. Glass and M. N. Varma (New York, NY: Plenum Press), pp. 99-135.
75. ROOTS, R., KRAFT, G. and GOSSCHALK, E., 1985, The formation of radiation-induced DNA breaks: the ratio of double-strand breaks to single-strand breaks. International Journal of Radiation Oncology, Biology, Physics, 11, 259-265.
76. ROOTS, R. and OKADA, S., 1975, Estimation of life times and diffusion distances of radicals involved in x-ray induced DNA strand breaks or killing of mammalian cells. Radiation Research, 64, 306-320.
77. RUIZ DE ALMODOVAR, J. M., STEEL, G. G., WHITAKER, S. J. and MCMILLAN, T. J., 1994, A comparison of methods for calculating DNA double-strand break induction frequency in mammalian cells by pulsed-field gel electrophoresis. International Journal of Radiation Biology, 65, 641-649.
78. RYDBERG, B., 1996, Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments. II. experimental detection. Radiation Research, 145, 200-209.
79. SAENGER, W., 1984, Principles of Nucleic Acid Structure (New York: Springer).
80. SCHOLES, G., WARD, J. F. and WEISS, J., 1960, Mechanisms of the radiation-induced degradation of nucleic acids. Journal of Molecular Biology, 2, 226-232.
81. SCHWARZ, H. A., 1969, Application of the spur diffusion model to the radiation chemistry of aqueous solutions. The Journal of Physical Chemistry, 73, 1928-1937.
82. SHORT, D. R., TRUMBORE, C. N. and OLSON, J. H., 1981, Extension of a spur overlap model for the radiolysis of water to include high linear energy regions. Journal of Physical Chemistry, 85, 2328-2335.
83. SIDDIQI, M. A. and BOTHE, E., 1987, Single- and double-strand break formation in DNA irradiated in aqueous solution: dependence on dose and OH radical scavenger concentration. Radiation Research, 112, 449-463.
84. SOLOMON, E., BORROW, J. and GODDARD, A. D., 1991, Chromosome aberrations and cancer. Science, 254, 1153-1160.
85. SPOTHEIM-MAURIZOT, M., CHARLIER, M. and SABATTIER, R., 1990, DNA radiolysis by fast neutrons. International Journal of Radiation Biology, 57, 301-313.
86. STENERLOW, B., BLOMQUIST, E., GRUSELL, E., HARTMAN, T. and CARLSSON, J., 1996, Rejoining of DNA double-strand breaks induced by accelerated nitrogen ions. International Journal of Radiation Biology, 70, 413-420.
87. STENERLOW, B., CARLSSON, J., BLOMQUIST, E. and ERIXON, K., 1994, Clonogenic cell survival and rejoining of DNA double-strand breaks: comparisons between three cell lines after photon or He ion irradiation. International Journal of Radiation Biology, 65, 631-639.
88. SWARTS, S. G., SEVILLA, M. D., BECKER, D., TOKAR, CH. J. and WHEELER, K. T., 1992, Radiation-induced DNA damage as a function of hydration. Radiation Research, 129, 333-344.
89. TERRISSOL, M. and BEAUDRE, A., 1990, Simulation of space and time evolution of radiolytic species induced by electrons in water. Radiation Protection Dosimetry, 31, 175-177.
90. TERRISSOL, M. and POMPLUN, E., 1994, A nucleosome model for the simulation of DNA strand break experiments. In Computational Approaches in Molecular Radiation Biology, edited by M. N. Varma and A. Catterjee (New York: Plenum Press), pp. 243-250.
91. TOMITA, H., KAI, M., KUSAMA, T., AOKI, Y. and ITO, A., 1994, Monte Carlo simulation of DNA strand breaks induced by monoenergetic electrons using higher-order structure models of DNA. International Journal of Radiation Biology, 66, 669-682.
92. TRANT, H., 1978, Molecular aspects of mutagenesis due to ionizing radiation. In Effects of Ionizing Radiation on DNA, edited by A. J. Bertinchamps, J. Hütterman, W. Köhnlein and R. Teoule (Berlin, New York: Springer-Verlag), pp. 335-354.
93. TRUMBORE, C. N., YOUNGBLADE, W. and SHORT, D. R., 1988, Modeling of gamma-ray radiolysis data at moderate and low solute concentrations in aqueous solutions. Radiation Physics Chemistry, 32, 233-239.
94. TURNER, J. E., HAMM, R. N., WRIGHT, H. A., RITCHIE, R. H., MAGEE, J. L., CHATTERJEE, A. and BOLCH, W. E., 1988, Studies to link the basic radiation physics and chemistry of liquid water. Radiation Physics Chemistry 32, 503-510.
95. TURNER, J. E., MAGEE, J. L., WRIGHT, H. A., CHATTERJEE, A., HAMM, R. N. and RITCHIE, R. H., 1983, Physical and chemical development of electron tracks in liquid water. Radiation Research, 96, 437-449.
96. UMRANIA, Y., NIKJOO, H. and GOODFELLOW, J. M., 1995, A knowledge-based model of DNA hydration. International Journal of Radiation Biology, 67, 145-152.
97. UNSCEAR (United Nations Committee on the Effects of Atomic Radiation), 1986, Genetic and somatic effects of ionizing radiation. Report to the General Assembly (New York, NY: UN).
98. VAN DER SCHANS, G. P., 1978, Gamma-ray induced double-strand breaks in DNA resulting from randomly-inflicted single-strand breaks: temporal local denaturation, a new radiation phenomenon? International Journal of Radiation Biology, 33, 105-120.
99. VON SONNTAG, C., 1980, Free radical reactions of carbohydrates as studied by radiation techniques. Advances in Carbohydrate Chemistry and Biochemistry, 37, 7-77.
100. VON SONNTAG, C., 1987, The Chemical Basis of Radiation Biology (Basingstoke, Hants: Taylor and Francis).
101. VON SONNTAG, C., 1991, The chemistry of free-radical-mediated DNA damage. In Physical and Chemical Mechanisms in Molecular Radiation Biology, edited by W. A. Glass and M. N. Varma (New York, NY: Plenum Press), pp. 287-321.
102. VON SONNTAG, C., 1994, Radiation chemistry in the 1990s: pressing questions relating to the areas of radiation biology and environmental research. International Journal of Radiation Biology, 65, 19-26.
103. VON SONNTAG, C. and DIZDAROGLU, M., 1977, The reactions of OH radicals with D-ribose in deoxygenated and oxygenated aqueous solution. Carbohydrate Research, 58, 21-30.
104. VON SONNTAG, C., HAGEN, U., SCHON-BOPP, A. and SCHULTE-FROHLINDE, D., 1981, Radiation-induced strand-breaks in DNA: chemical and enzymatic analysis of end groups and mechanistic aspects. Advances in Radiation Biology, 9, 109-142.
105. WANG, W., BECKER, D. and SEVILLA, M. D., 1993, The influence of hydration on the absolute yields of primary ionic free radicals in gamma irradiated DNA at 77 K. I. Total radical yields. Radiation Research, 135, 146-154.
106. WARD, J. F., 1985, Biochemistry of DNA lesions. Radiation Research, 104, S103-S111.
107. WARD, J. F., 1988, DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation and repairability. Progress in Nucliec Acids and Molecular Biology, 75, 278-285.
108. WARD, J. F., 1990, The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review. International Journal of Radiation Biology, 57, 1141-1150.
109. WARD, J. F., 1991, DNA damage and repair. In Physical and Chemical Mechanisms in Molecular Radiation Biology, edited by W. A. Glass and M. N. Varma (New York, NY: Plenum Press), pp. 403-421.
110. WARD, J. F., 1994, The complexity of DNA damage: relevance to biological consequences. International Journal of Radiation Biology, 66, 427-432.
111. WEBER, K. J. and FLENTJE, M., 1993, Lethality of heavy ion-induced DNA double-strand breaks in mammalian cells. International Journal of Radiation Biology, 64, 169-178.
112. WHITAKER, S. J. and MCMILLAN, T. J., 1992, Oxygen effect for DNA double-strand break induction determined by pulsed-field gel electrophoresis. International Journal of Radiation Biology, 61, 29-41.
113. WONG, R. S. L., DYNLACHT, J. R., CEDERVALL, B. and DEWEY, W. C., 1995, Analysis by pulsed-field gel electrophoresis of DNA double-strand breaks induced by heat and/or X-irradiation in bulk and replicating DNA of CHO cells. International Journal of Radiation Biology, 68, 141-152.
114. WRIGHT, H. A., MAGEE, J. L., HAMM, R. N., CHATTERJEE, A., TURNER, J. E. and KLOTS, C. E., 1985, Calculation of physical and chemical reactions produced in irradiated water containing DNA. Radiation Protection Dosimetry, 13, 133-136.
115. XAPSOS, M. A. and POGOZELSKI, W. K., 1996, Modeling the yield of double-strand breaks due to formation of multiply damaged sites in irradiated plasmid DNA. Radiation Research, 146, 668-672.
116. ZAIDER, M. and BRENNER, D. J., 1984, On the stochastic treatment of fast chemical reactions. Radiation Research, 100, 245-256.
117. ZIMMER, K. G., 1961, Quantitative Radiation Biology (Edinburgh: Oliver and Boyd).